PLCG2 and LYN

Number of citations of the paper that reports this interaction (PMID 15144186)
48

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		PLCG2	LYN
Gene Name		phospholipase C, gamma 2 (phosphatidylinositol-specific)	LYN proto-oncogene, Src family tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm Mitochondrial Intermembrane Space Golgi Apparatus Cytosol Plasma Membrane Postsynaptic Density Mitochondrial Crista Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Integrin Alpha2-beta1 Complex Mast Cell Granule Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Signal Transducer Activity Protein Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Receptor Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Protein Binding ATP Binding SH3 Domain Binding Enzyme Binding Ubiquitin Protein Ligase Binding Glycosphingolipid Binding Ion Channel Binding Phosphoprotein Binding
	Biological Process	Follicular B Cell Differentiation Phosphatidylinositol Biosynthetic Process Blood Coagulation Phospholipid Catabolic Process Regulation Of Gene Expression Wnt Signaling Pathway Calcium-mediated Signaling Platelet Activation B Cell Differentiation Activation Of Store-operated Calcium Channel Activity Response To Lipopolysaccharide Inositol Trisphosphate Biosynthetic Process Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Programmed Cell Death Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Innate Immune Response T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol	B Cell Homeostasis Regulation Of Cytokine Production Regulation Of Protein Phosphorylation Negative Regulation Of Protein Phosphorylation Fc Receptor Mediated Stimulatory Signaling Pathway Tolerance Induction To Self Antigen Histamine Secretion By Mast Cell Platelet Degranulation Negative Regulation Of Myeloid Leukocyte Differentiation Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Inhibitory Signaling Pathway Regulation Of B Cell Apoptotic Process Protein Phosphorylation Inflammatory Response Cellular Response To DNA Damage Stimulus Response To Sterol Depletion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Central Nervous System Development Blood Coagulation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Toxic Substance Response To Hormone Response To Carbohydrate Positive Regulation Of Neuron Projection Development Oligodendrocyte Development Response To Organic Cyclic Compound Viral Process Peptidyl-tyrosine Phosphorylation Signal Transduction By Phosphorylation Platelet Activation Erythrocyte Differentiation Positive Regulation Of Cell Migration Negative Regulation Of B Cell Proliferation T Cell Costimulation Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Extracellular Stimulus Response To Insulin Regulation Of Mast Cell Activation Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Heat Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Response To Drug Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Response To Amino Acid Regulation Of Mast Cell Degranulation Negative Regulation Of MAP Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Regulation Of Erythrocyte Differentiation Protein Autophosphorylation Ephrin Receptor Signaling Pathway Response To Axon Injury Cytokine Secretion Regulation Of Cytokine Secretion Regulation Of Inflammatory Response Negative Regulation Of Immune Response B Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of B Cell Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Cellular Component Movement Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Oligodendrocyte Progenitor Proliferation Negative Regulation Of Mast Cell Proliferation Positive Regulation Of Mast Cell Proliferation Cellular Response To Retinoic Acid Cellular Response To Peptide Hormone Stimulus Regulation Of Monocyte Chemotaxis Regulation Of Platelet Aggregation Dendritic Cell Differentiation Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Dendritic Cell Apoptotic Process
Pathways		Signaling by the B Cell Receptor (BCR) DAP12 interactions FCERI mediated MAPK activation Inositol phosphate metabolism DAP12 signaling Toll-Like Receptors Cascades Synthesis of IP3 and IP4 in the cytosol Toll Like Receptor 4 (TLR4) Cascade Role of phospholipids in phagocytosis GPVI-mediated activation cascade Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Fcgamma receptor (FCGR) dependent phagocytosis Platelet activation, signaling and aggregation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System Innate Immune System	Signaling by the B Cell Receptor (BCR) Platelet Adhesion to exposed collagen Axon guidance Costimulation by the CD28 family FCERI mediated MAPK activation Signaling by SCF-KIT EPHB-mediated forward signaling EPHA-mediated growth cone collapse Regulation of KIT signaling FCERI mediated NF-kB activation EPH-ephrin mediated repulsion of cells Regulation of signaling by CBL EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System CD28 co-stimulation CTLA4 inhibitory signaling Cytokine Signaling in Immune system Role of LAT2/NTAL/LAB on calcium mobilization Cell surface interactions at the vascular wall PECAM1 interactions Signaling by Interleukins Fc epsilon receptor (FCERI) signaling GPVI-mediated activation cascade FCERI mediated Ca+2 mobilization Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System Growth hormone receptor signaling
Drugs
Diseases
GWAS			Height ( 18391951)
Protein-Protein Interactions		34 interactors: BLK BLNK BTK CBLB CD19 DAPP1 EGFR EPOR ERBB2 FCER1G FLT1 FYN GAB1 GAB2 HCK IRS1 ITK JAK1 JAK2 KDR KHDRBS1 LAT LAT2 LCK LCP2 LIME1 LYN NPM1 PRKD1 SH3BP2 SHC1 SYK TEC ZNF512B	115 interactors: ACTB ADAM15 BANK1 BCAR1 BTK CASP3 CASP7 CASP9 CBL CBLC CD19 CD22 CD36 CD72 CD79A CD79B CDK1 CDK2 CDKN1B CHST15 CREBBP CRKL CSF1R CSF2RA CSF2RB CSF3R CSK CSNK2B CTLA4 DAPP1 DLG4 DOK1 DOK2 DOK3 EGFR EPOR EVL FASLG FCAR FCER1G FCGR2A FCGR2B FOLR1 GAB2 GAB3 GP6 GRIA3 HCLS1 HNRNPK IL1B IL2RB IL7R INPP5D ITPR1 JAK2 KHDRBS1 KIT LCP2 LIME1 MAP4K1 MAPK3 MATK MME MS4A1 MS4A2 MUC1 NDFIP2 NEDD9 NMT1 NPHS1 PAG1 PAK2 PDE4A PDE4D PECAM1 PIK3CG PILRB PLCG1 PLCG2 PPP1R15A PPP1R8 PRAM1 PRKCD PRKCQ PRKDC PTK2 PTK2B PTPN6 PTPRC RASA1 RGS16 RPL10 RPS6KB1 RPS6KB2 SH2B2 SHC1 SKAP1 SKAP2 SLC4A1 SNCA SPHK1 SPHK2 SRC STAT3 SYK TEC TNF TRAT1 TRIM28 TRIP10 TRPV4 TYK2 UBB UHRF2 UNC119
Entrez ID		5336	4067
HPRD ID		02570	01301
Ensembl ID		ENSG00000197943	ENSG00000254087
Uniprot IDs		P16885	A8K379 P07948 Q6NUK7
PDB IDs		2K2J 2W2W 2W2X	1W1F 1WA7 3A4O
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Innate Immune Response Peptidyl-tyrosine Autophosphorylation Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Immune Response Protein Autophosphorylation Immune System Process Regulation Of Immune System Process Peptidyl-tyrosine Phosphorylation Defense Response Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Signaling Cell Communication B Cell Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Stimulus Regulation Of Cell Proliferation Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Peptidyl-amino Acid Modification Cell Activation Positive Regulation Of Signal Transduction Response To Stimulus Response To Stress Leukocyte Activation Protein Phosphorylation Cellular Response To Organic Substance Response To Organic Substance Regulation Of Cell Activation Cell Migration Locomotion Phosphorylation Cell Motility Mast Cell Activation Phosphatidylinositol-mediated Signaling Wound Healing Leukocyte Migration Movement Of Cell Or Subcellular Component Regulation Of Signaling Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway	Signal Transduction Signaling Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Cellular Response To Stimulus Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response Enzyme Linked Receptor Protein Signaling Pathway Innate Immune Response Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune Response Intracellular Signal Transduction Positive Regulation Of Immune System Process Defense Response Fc Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Response To Stress Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc-epsilon Receptor Signaling Pathway Cellular Response To Organic Substance Regulation Of Protein Metabolic Process Cell Activation Regulation Of Signaling Response To Organic Substance Regulation Of Protein Phosphorylation Regulation Of Cellular Process Regulation Of Cellular Protein Metabolic Process Locomotion Positive Regulation Of Protein Modification Process Response To Wounding Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Blood Coagulation Positive Regulation Of Protein Phosphorylation Movement Of Cell Or Subcellular Component Hemostasis Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway Platelet Activation
Tagcloud ?		16x10 associations chrne comprehensively dysregulated escc esccs esophageal fyn gc gcs germline gnai3 han itch map2k1 map2k4 mapk8 observe pak4 pik3r3 prlr rank resampling rps6kb2 tln1 validate warranted wasl	5r abrogated amino betac binding blocked coupled created csf exact finding granulocyte help involves macrophage map modules narrowed nine overlapping permeable physically proline proximal residues sequential site stearation unstimulated
Tagcloud (Difference) ?		16x10 associations chrne comprehensively dysregulated escc esccs esophageal fyn gc gcs germline gnai3 han itch map2k1 map2k4 mapk8 observe pak4 pik3r3 prlr rank resampling rps6kb2 tln1 validate warranted wasl	5r abrogated amino betac binding blocked coupled created csf exact finding granulocyte help involves macrophage map modules narrowed nine overlapping permeable physically proline proximal residues sequential site stearation unstimulated
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