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CFL1 and PSEN1
Number of citations of the paper that reports this interaction (PubMedID
21163940
)
58
Data Source:
BioGRID
(two hybrid)
CFL1
PSEN1
Description
cofilin 1
presenilin 1
Image
GO Annotations
Cellular Component
Extracellular Space
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Actin Cytoskeleton
Membrane
Nuclear Matrix
Lamellipodium
Filopodium
Axon
Growth Cone
Cortical Actin Cytoskeleton
Cell Leading Edge
Lamellipodium Membrane
Mitochondrial Membrane
Vesicle
Ruffle Membrane
Cell Projection
Neuronal Cell Body
Dendritic Spine
Extracellular Exosome
Cofilin-actin Rod
Synaptic Membrane
Glutamatergic Synapse
Postsynaptic Density, Intracellular Component
Golgi Membrane
Kinetochore
Nucleus
Nuclear Outer Membrane
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Inner Membrane
Lysosomal Membrane
Endosome
Early Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Smooth Endoplasmic Reticulum
Rough Endoplasmic Reticulum
Golgi Apparatus
Centrosome
Plasma Membrane
Cell Cortex
Synaptic Vesicle
Cell Surface
Membrane
Aggresome
Cell Junction
Axon
Dendrite
Growth Cone
Cytoplasmic Vesicle
Neuromuscular Junction
Early Endosome Membrane
Nuclear Membrane
Protein-containing Complex
Ciliary Rootlet
Azurophil Granule Membrane
Sarcolemma
Presynaptic Membrane
Cell Projection
Neuron Projection
Neuronal Cell Body
Dendritic Shaft
Membrane Raft
Synapse
Gamma-secretase Complex
Synaptic Membrane
Postsynapse
Glutamatergic Synapse
Molecular Function
Actin Binding
Signaling Receptor Binding
Protein Binding
Protein Phosphatase Binding
Actin Filament Binding
Phosphatidylinositol Bisphosphate Binding
Endopeptidase Activity
Aspartic-type Endopeptidase Activity
Calcium Channel Activity
Protein Binding
Beta-catenin Binding
Peptidase Activity
Hydrolase Activity
PDZ Domain Binding
Aspartic Endopeptidase Activity, Intramembrane Cleaving
Cadherin Binding
ATPase Binding
Growth Factor Receptor Binding
Biological Process
Mitotic Cytokinesis
Neural Crest Cell Migration
Neural Fold Formation
Protein Import Into Nucleus
Cytoskeleton Organization
Actin Filament Organization
Negative Regulation Of Cell Adhesion
Rho Protein Signal Transduction
Actin Polymerization Or Depolymerization
Response To Virus
Positive Regulation Of Lamellipodium Assembly
Negative Regulation Of Lamellipodium Assembly
Response To Activity
Hippocampus Development
Regulation Of Cell Morphogenesis
Establishment Of Cell Polarity
Cell Projection Organization
Actin Cytoskeleton Organization
Actin Filament Depolymerization
Actin Filament Fragmentation
Positive Regulation Of Cell Growth
Negative Regulation Of Actin Filament Depolymerization
Positive Regulation Of Actin Filament Depolymerization
Positive Regulation Of Synaptic Plasticity
Negative Regulation Of Actin Filament Bundle Assembly
Positive Regulation Of Embryonic Development
Negative Regulation Of Apoptotic Process
Response To Amino Acid
Host-mediated Activation Of Viral Process
Negative Regulation Of Cell Size
Positive Regulation Of Proteolysis
Cell Motility
Modulation Of Chemical Synaptic Transmission
Actin Filament Severing
Establishment Of Spindle Localization
Negative Regulation Of Unidimensional Cell Growth
Positive Regulation Of Focal Adhesion Assembly
Positive Regulation Of Dendritic Spine Development
Regulation Of Dendritic Spine Morphogenesis
Cellular Response To Hydrogen Peroxide
Cellular Response To Interleukin-1
Cellular Response To Interleukin-6
Cellular Response To Tumor Necrosis Factor
Cellular Response To Ether
Cellular Response To Epidermal Growth Factor Stimulus
Modification Of Postsynaptic Actin Cytoskeleton
Negative Regulation Of Dendritic Spine Maintenance
Positive Regulation Of Protein Localization To Cell Leading Edge
Negative Regulation Of Postsynaptic Density Organization
Cellular Response To Insulin-like Growth Factor Stimulus
Negative Regulation Of Cell Motility
Positive Regulation Of Cell Motility
Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape
Positive Regulation Of Barbed-end Actin Filament Capping
Autophagosome Assembly
Negative Regulation Of Transcription By RNA Polymerase II
Blood Vessel Development
Cell Fate Specification
Somitogenesis
Neuron Migration
Positive Regulation Of Receptor Recycling
Heart Looping
Positive Regulation Of L-glutamate Import Across Plasma Membrane
Hematopoietic Progenitor Cell Differentiation
Astrocyte Activation Involved In Immune Response
T Cell Activation Involved In Immune Response
Myeloid Leukocyte Differentiation
Neural Retina Development
Protein Glycosylation
Proteolysis
Membrane Protein Ectodomain Proteolysis
Mitochondrial Transport
Intracellular Calcium Ion Homeostasis
Autophagy
Apoptotic Process
DNA Damage Response
Response To Oxidative Stress
Cell Adhesion
Notch Signaling Pathway
Notch Receptor Processing
Brain Development
Heart Development
Learning Or Memory
Memory
Post-embryonic Development
Gene Expression
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Neuron Projection Development
Protein Transport
Choline Transport
Synaptic Vesicle Targeting
Protein Processing
Cerebellum Development
Cerebral Cortex Cell Migration
Cajal-Retzius Cell Differentiation
Dorsal/ventral Neural Tube Patterning
Cerebral Cortex Development
Neurogenesis
Neuron Differentiation
Embryonic Limb Morphogenesis
Forebrain Development
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Endoplasmic Reticulum Calcium Ion Homeostasis
Positive Regulation Of Tumor Necrosis Factor Production
Amyloid-beta Formation
Segmentation
Intracellular Signal Transduction
Locomotion
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Protein Import Into Nucleus
Regulation Of Phosphorylation
Amyloid Precursor Protein Metabolic Process
Amyloid Precursor Protein Catabolic Process
Myeloid Dendritic Cell Differentiation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Skin Morphogenesis
Positive Regulation Of Glycolytic Process
Positive Regulation Of DNA-templated Transcription
Astrocyte Activation
Regulation Of Synaptic Plasticity
Thymus Development
Neuron Development
Skeletal System Morphogenesis
Brain Morphogenesis
Amyloid-beta Metabolic Process
Epithelial Cell Proliferation
Negative Regulation Of Axonogenesis
Synapse Organization
Positive Regulation Of Coagulation
T Cell Receptor Signaling Pathway
Sequestering Of Calcium Ion
Neuron Apoptotic Process
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Protein Maturation
Regulation Of Synaptic Transmission, Glutamatergic
Calcium Ion Homeostasis
Regulation Of Resting Membrane Potential
Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Dendritic Spine Development
Neuron Cellular Homeostasis
Calcium Ion Transmembrane Transport
Apoptotic Signaling Pathway
Cell-cell Adhesion
Regulation Of Synaptic Vesicle Cycle
L-glutamate Import Across Plasma Membrane
Regulation Of Postsynapse Organization
Protein Catabolic Process At Postsynapse
Cellular Response To Amyloid-beta
Negative Regulation Of Core Promoter Binding
Positive Regulation Of Amyloid Fibril Formation
Neuron Projection Maintenance
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Apoptotic Signaling Pathway
Pathways
Platelet degranulation
Regulation of actin dynamics for phagocytic cup formation
EPHB-mediated forward signaling
Sema3A PAK dependent Axon repulsion
RHO GTPases Activate ROCKs
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Nuclear signaling by ERBB4
Degradation of the extracellular matrix
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
EPH-ephrin mediated repulsion of cells
Neutrophil degranulation
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH4 Activation and Transmission of Signal to the Nucleus
Noncanonical activation of NOTCH3
TGFBR3 PTM regulation
Drugs
Dodecyldimethylamine N-oxide
Copper
Artenimol
Diseases
Alzheimer's disease (AD)
Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
Acne inversa; Hidradenitis supprativa
GWAS
Acne (severe) (
24927181
)
Basal cell carcinoma (
31174203
)
Breast cancer (
23535729
)
DNA methylation (variation) (
23725790
)
Keratinocyte cancer (MTAG) (
31174203
)
Neutrophil count (
32888494
)
Platelet count (
32888494
)
Psoriasis (
28537254
)
Waist circumference adjusted for body mass index (
34021172
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
White blood cell count (
32888494
)
Apolipoprotein B levels (
32203549
)
Glycated hemoglobin levels (
34059833
)
Red cell distribution width (
32888494
)
Refractive error (
32231278
)
Reticulocyte fraction of red cells (
32888494
)
Interacting Genes
46 interacting genes:
ACTA1
ACTA2
ACTB
ACTC1
ACTG1
APP
ATP1A1
ATXN1
CLCN5
ERBB2
ERBB3
ERBB4
ESR1
FLNA
FNDC3B
HSPH1
LIMK1
LIMK2
MAPK6
MAPK8IP2
MYCBP
MYCBP2
NRK
POT1
PSEN1
PTEN
RAD21
RPS6KA1
SLC2A4
SNRPA
SRC
SSH1
SSH2
SSH3
TAB1
TERF1
TESK1
TESK2
TPI1
TRIM15
UBE2M
UCHL5
WDR1
YWHAG
YWHAQ
YWHAZ
92 interacting genes:
ACTN1
AP1M2
APBA1
APH1A
APH1B
APOE
APP
BACE1
BCL2
BCL2L1
CASP1
CASP3
CASP4
CASP6
CASP7
CASP8
CDH1
CDK5
CFL1
CIB1
CTNNA1
CTNNB1
CTNND1
CTNND2
CYP2C18
CYP2C8
DLL1
DOCK3
ECSIT
EFHD1
EFNB2
ENSA
EPB41L3
ERN1
ETFA
FBXL12
FBXW7
FGF13
FLNA
FLNB
GAPDH
GCDH
GDI1
GFAP
GSK3B
HERPUD1
HMGB1
ICAM5
ITSN2
JUP
KANK2
KCNIP3
KCNIP4
MAPK9
MAPT
METTL2B
MTCH1
NCSTN
NOS3
NOTCH1
NOTCH2
NOTCH3
NOTCH4
OXCT1
PDCD4
PIK3R1
PKP4
PRAM1
PRDX2
PRKACA
PRKCZ
PSENEN
PSMA5
PSMB1
RAB11A
RAB3A
RAD23A
RHEB
RMDN3
RNF32
RYR2
SCAF11
SCN1A
SLC10A6
ST13
STAMBPL1
TCF7L2
TDP2
TUBA1B
UBQLN1
UMPS
YME1L1
Entrez ID
1072
5663
HPRD ID
03261
00087
Ensembl ID
ENSG00000172757
ENSG00000080815
Uniprot IDs
P23528
V9HWI5
A0A024R6A3
A0A0S2Z4D2
P49768
PDB IDs
1Q8G
1Q8X
3J0S
4BEX
5HVK
5L6W
6UBY
6UC0
6UC4
6VAO
2KR6
4UIS
5A63
5FN2
5FN3
5FN4
5FN5
6IDF
6IYC
6LQG
6LR4
7C9I
7D8X
7Y5T
8IM7
8K8E
8KCO
8KCP
8KCS
8KCT
8KCU
8OQY
8OQZ
8X52
8X53
8X54
Enriched GO Terms of Interacting Partners
?
Actin Cytoskeleton Organization
Actin Filament-based Process
ATP Binding
Regulation Of Organelle Organization
Regulation Of Cellular Component Organization
Nucleotide Binding
Focal Adhesion
Protein Modification Process
Cytoplasm
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Protein Localization
Regulation Of Supramolecular Fiber Organization
Protein Kinase Activity
Regulation Of Multicellular Organismal Process
Actin Filament
Cytoskeleton
Positive Regulation Of Multicellular Organismal Process
Mesenchyme Migration
Regulation Of Protein Localization To Nucleus
Cytoskeleton Organization
Regulation Of Membrane Potential
Developmental Process
Protein Phosphorylation
Cell Junction Organization
ERBB2 Signaling Pathway
Positive Regulation Of Metabolic Process
Regulation Of Actin Filament Organization
Kinase Activity
Protein-containing Complex
Lamellipodium
Regulation Of Actin Filament-based Process
Anatomical Structure Morphogenesis
Phosphorylation
Organelle Organization
Positive Regulation Of Cell Activation
Protein Tyrosine Kinase Activity
Regulation Of Macromolecule Biosynthetic Process
Phosphatase Activity
Positive Regulation Of Signaling
Negative Regulation Of Apoptotic Process
Intracellular Signal Transduction
Negative Regulation Of Cellular Component Organization
Positive Regulation Of Signal Transduction
Protein Localization To Cell Junction
Positive Regulation Of MAPK Cascade
Negative Regulation Of Programmed Cell Death
Regulation Of Actin Cytoskeleton Organization
Protein Serine/threonine Phosphatase Activity
Regulation Of Cell Communication
Regulation Of Programmed Cell Death
Regulation Of Signaling
Regulation Of Apoptotic Process
Plasma Membrane
Positive Regulation Of Neuron Apoptotic Process
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Apoptotic Process
Regulation Of Protein Localization
Regulation Of Cell Development
Neuron Projection Development
Cytoplasm
Regulation Of Cell Differentiation
Programmed Cell Death
Regulation Of Developmental Process
Cell Death
Negative Regulation Of Developmental Process
Regulation Of Transport
Protein Processing
Cellular Response To Oxygen-containing Compound
Notch Signaling Pathway
Cytosol
Amyloid-beta Formation
Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Neuron Apoptotic Process
Positive Regulation Of Signal Transduction
Regulation Of Biological Quality
Amyloid Precursor Protein Metabolic Process
Apoptotic Signaling Pathway
Negative Regulation Of Cell Development
Cellular Response To Indole-3-methanol
Cell Junction Organization
Regulation Of Establishment Of Protein Localization
Response To Indole-3-methanol
Cellular Localization
Modulation Of Chemical Synaptic Transmission
Cell-cell Junction
Regulation Of Synaptic Plasticity
Positive Regulation Of Proteolysis
Regulation Of Autophagy
Regulation Of Multicellular Organismal Process
Positive Regulation Of Protein Localization
Regulation Of Intracellular Signal Transduction
Protein Maturation
Regulation Of Developmental Growth
Amyloid Precursor Protein Catabolic Process
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Tagcloud (Intersection)
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