CFL1 and TESK1

Number of citations: 45 (PubMedID 11294912)
Data Source: HPRD (in vitro, in vivo)

		CFL1	TESK1
Name		cofilin 1	testis associated actin remodelling kinase 1
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Nuclear Matrix Lamellipodium Filopodium Axon Growth Cone Cortical Actin Cytoskeleton Cell Leading Edge Lamellipodium Membrane Mitochondrial Membrane Vesicle Ruffle Membrane Cell Projection Neuronal Cell Body Dendritic Spine Extracellular Exosome Cofilin-actin Rod Synaptic Membrane Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Lamellipodium Cytoplasmic Vesicle Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Actin Binding Signaling Receptor Binding Protein Binding Protein Phosphatase Binding Actin Filament Binding Phosphatidylinositol Bisphosphate Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Mitotic Cytokinesis Neural Crest Cell Migration Neural Fold Formation Protein Import Into Nucleus Cytoskeleton Organization Actin Filament Organization Negative Regulation Of Cell Adhesion Rho Protein Signal Transduction Actin Polymerization Or Depolymerization Response To Virus Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Lamellipodium Assembly Response To Activity Hippocampus Development Regulation Of Cell Morphogenesis Establishment Of Cell Polarity Cell Projection Organization Actin Cytoskeleton Organization Actin Filament Depolymerization Actin Filament Fragmentation Positive Regulation Of Cell Growth Negative Regulation Of Actin Filament Depolymerization Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Synaptic Plasticity Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Embryonic Development Negative Regulation Of Apoptotic Process Response To Amino Acid Host-mediated Activation Of Viral Process Negative Regulation Of Cell Size Positive Regulation Of Proteolysis Cell Motility Modulation Of Chemical Synaptic Transmission Actin Filament Severing Establishment Of Spindle Localization Negative Regulation Of Unidimensional Cell Growth Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Cellular Response To Hydrogen Peroxide Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Ether Cellular Response To Epidermal Growth Factor Stimulus Modification Of Postsynaptic Actin Cytoskeleton Negative Regulation Of Dendritic Spine Maintenance Positive Regulation Of Protein Localization To Cell Leading Edge Negative Regulation Of Postsynaptic Density Organization Cellular Response To Insulin-like Growth Factor Stimulus Negative Regulation Of Cell Motility Positive Regulation Of Cell Motility Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Positive Regulation Of Barbed-end Actin Filament Capping	Spermatogenesis Actin Cytoskeleton Organization Regulation Of Protein Localization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Establishment Of Vesicle Localization Nuclear-transcribed MRNA Catabolic Process, No-go Decay Podocyte Cell Migration Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cilium Assembly
Pathways		Platelet degranulation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion RHO GTPases Activate ROCKs Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Drugs		Dodecyldimethylamine N-oxide Copper Artenimol	Fostamatinib
GWAS		Acne (severe) ( 24927181 ) Basal cell carcinoma ( 31174203 ) Breast cancer ( 23535729 ) DNA methylation (variation) ( 23725790 ) Keratinocyte cancer (MTAG) ( 31174203 ) Neutrophil count ( 32888494 ) Platelet count ( 32888494 ) Psoriasis ( 28537254 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) White blood cell count ( 32888494 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: CD5	1 novel interactors: IL17RA
Interacting Genes		46 interacting genes: ACTA1 ACTA2 ACTB ACTC1 ACTG1 APP ATP1A1 ATXN1 CLCN5 ERBB2 ERBB3 ERBB4 ESR1 FLNA FNDC3B HSPH1 LIMK1 LIMK2 MAPK6 MAPK8IP2 MYCBP MYCBP2 NRK POT1 PSEN1 PTEN RAD21 RPS6KA1 SLC2A4 SNRPA SRC SSH1 SSH2 SSH3 TAB1 TERF1 TESK1 TESK2 TPI1 TRIM15 UBE2M UCHL5 WDR1 YWHAG YWHAQ YWHAZ	7 interacting genes: ABCB4 ARAF CFL1 PFKL SPRY4 YWHAB YY1
Entrez ID		1072	7016
HPRD ID		03261	03470
Ensembl ID		ENSG00000172757	ENSG00000107140
Uniprot IDs		P23528 V9HWI5	Q15569 Q8NFJ4
PDB IDs		1Q8G 1Q8X 3J0S 4BEX 5HVK 5L6W 6UBY 6UC0 6UC4 6VAO	Not available
GO Terms Enriched among Interactors		Actin Cytoskeleton Organization Actin Filament-based Process ATP Binding Regulation Of Organelle Organization Regulation Of Cellular Component Organization Nucleotide Binding Focal Adhesion Protein Modification Process Cytoplasm Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Localization Regulation Of Supramolecular Fiber Organization Protein Kinase Activity Regulation Of Multicellular Organismal Process Actin Filament Cytoskeleton Positive Regulation Of Multicellular Organismal Process Mesenchyme Migration Regulation Of Protein Localization To Nucleus Cytoskeleton Organization Regulation Of Membrane Potential Developmental Process Protein Phosphorylation Cell Junction Organization ERBB2 Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Actin Filament Organization Kinase Activity Protein-containing Complex Lamellipodium Regulation Of Actin Filament-based Process Anatomical Structure Morphogenesis Phosphorylation Organelle Organization Positive Regulation Of Cell Activation Protein Tyrosine Kinase Activity Regulation Of Macromolecule Biosynthetic Process Phosphatase Activity Positive Regulation Of Signaling Negative Regulation Of Apoptotic Process Intracellular Signal Transduction Negative Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Protein Localization To Cell Junction Positive Regulation Of MAPK Cascade Negative Regulation Of Programmed Cell Death Regulation Of Actin Cytoskeleton Organization Protein Serine/threonine Phosphatase Activity	Response To Ether Focal Adhesion Cofilin-actin Rod Cellular Response To Interleukin-1 Negative Regulation Of Unidimensional Cell Growth Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Positive Regulation Of Barbed-end Actin Filament Capping Positive Regulation Of Protein Localization To Cell Leading Edge Protein Kinase Inhibitor Activity Response To Interleukin-1 Regulation Of Embryonic Development Negative Regulation Of Developmental Growth Cellular Response To Cytokine Stimulus Ruffle Membrane Negative Regulation Of Postsynaptic Density Organization Response To Fenofibrate Immunoglobulin Heavy Chain V-D-J Recombination Regulation Of Protein Localization To Cell Leading Edge 6-phosphofructokinase Activity Negative Regulation Of Protein Transport 6-phosphofructokinase Complex Cellular Response To Bile Acid Ceramide Floppase Activity Ceramide Translocation Response To Prostaglandin F Interleukin-17 Receptor Activity Nuclear Matrix Response To Peptide Response To Cytokine Neural Fold Formation Actin Filament Fragmentation Fructose-6-phosphate Binding Negative Regulation Of Establishment Of Protein Localization Negative Regulation Of Cell Growth Negative Regulation Of Dendritic Spine Maintenance Regulation Of Barbed-end Actin Filament Capping Negative Regulation Of Lamellipodium Assembly Intercellular Canaliculus Positive Regulation Of Phospholipid Translocation Bile Acid Secretion Sphingolipid Translocation Response To Bile Acid Phosphatidylcholine Floppase Activity Phosphoserine Residue Binding T-helper 17 Type Immune Response Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Interleukin-17A-mediated Signaling Pathway Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Fructose Binding Monosaccharide Binding