CFL1 and CLCN5

Number of citations of the paper that reports this interaction (PubMedID 12904289)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		CFL1	CLCN5
Description		cofilin 1	chloride voltage-gated channel 5
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GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Nuclear Matrix Lamellipodium Filopodium Axon Growth Cone Cortical Actin Cytoskeleton Cell Leading Edge Lamellipodium Membrane Mitochondrial Membrane Vesicle Ruffle Membrane Cell Projection Neuronal Cell Body Dendritic Spine Extracellular Exosome Cofilin-actin Rod Synaptic Membrane Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Golgi Membrane Lysosomal Membrane Endosome Early Endosome Golgi Apparatus Cytosol Plasma Membrane Synaptic Vesicle Endosome Membrane Membrane Apical Part Of Cell
	Molecular Function	Actin Binding Signaling Receptor Binding Protein Binding Protein Phosphatase Binding Actin Filament Binding Phosphatidylinositol Bisphosphate Binding	Nucleotide Binding Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Chloride Transmembrane Transporter Activity Antiporter Activity Identical Protein Binding
	Biological Process	Mitotic Cytokinesis Neural Crest Cell Migration Neural Fold Formation Protein Import Into Nucleus Cytoskeleton Organization Actin Filament Organization Negative Regulation Of Cell Adhesion Rho Protein Signal Transduction Actin Polymerization Or Depolymerization Response To Virus Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Lamellipodium Assembly Response To Activity Hippocampus Development Regulation Of Cell Morphogenesis Establishment Of Cell Polarity Cell Projection Organization Actin Cytoskeleton Organization Actin Filament Depolymerization Actin Filament Fragmentation Positive Regulation Of Cell Growth Negative Regulation Of Actin Filament Depolymerization Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Synaptic Plasticity Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Embryonic Development Negative Regulation Of Apoptotic Process Response To Amino Acid Host-mediated Activation Of Viral Process Negative Regulation Of Cell Size Positive Regulation Of Proteolysis Cell Motility Modulation Of Chemical Synaptic Transmission Actin Filament Severing Establishment Of Spindle Localization Negative Regulation Of Unidimensional Cell Growth Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Cellular Response To Hydrogen Peroxide Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Ether Cellular Response To Epidermal Growth Factor Stimulus Modification Of Postsynaptic Actin Cytoskeleton Negative Regulation Of Dendritic Spine Maintenance Positive Regulation Of Protein Localization To Cell Leading Edge Negative Regulation Of Postsynaptic Density Organization Cellular Response To Insulin-like Growth Factor Stimulus Negative Regulation Of Cell Motility Positive Regulation Of Cell Motility Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Positive Regulation Of Barbed-end Actin Filament Capping	Renal System Process Monoatomic Ion Transport Chloride Transport Endocytosis Monoatomic Ion Transmembrane Transport Transmembrane Transport Chloride Transmembrane Transport
Pathways		Platelet degranulation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion RHO GTPases Activate ROCKs Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Stimuli-sensing channels
Drugs		Dodecyldimethylamine N-oxide Copper Artenimol
Diseases			Dent disease, including: Dent disease 1; Dent disease 2; X-linked recessive nephrolithiasis ; Hypophosphatemic rickets; Low-molecular-weight proteinuria with hypercalciuria and nephrocalcinosis
GWAS		Acne (severe) ( 24927181) Basal cell carcinoma ( 31174203) Breast cancer ( 23535729) DNA methylation (variation) ( 23725790) Keratinocyte cancer (MTAG) ( 31174203) Neutrophil count ( 32888494) Platelet count ( 32888494) Psoriasis ( 28537254) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)	Height ( 28552196) Hip circumference adjusted for BMI ( 28552196) Red blood cell count ( 32888494)
Interacting Genes		46 interacting genes: ACTA1 ACTA2 ACTB ACTC1 ACTG1 APP ATP1A1 ATXN1 CLCN5 ERBB2 ERBB3 ERBB4 ESR1 FLNA FNDC3B HSPH1 LIMK1 LIMK2 MAPK6 MAPK8IP2 MYCBP MYCBP2 NRK POT1 PSEN1 PTEN RAD21 RPS6KA1 SLC2A4 SNRPA SRC SSH1 SSH2 SSH3 TAB1 TERF1 TESK1 TESK2 TPI1 TRIM15 UBE2M UCHL5 WDR1 YWHAG YWHAQ YWHAZ	4 interacting genes: CFL1 MAGI1 WWP1 WWP2
Entrez ID		1072	1184
HPRD ID		03261	02053
Ensembl ID		ENSG00000172757	ENSG00000171365
Uniprot IDs		P23528 V9HWI5	A8K4H5 B3KRR2 P51795 V9GYG7
PDB IDs		1Q8G 1Q8X 3J0S 4BEX 5HVK 5L6W 6UBY 6UC0 6UC4 6VAO	2J9L 2JA3
Enriched GO Terms of Interacting Partners?		Actin Cytoskeleton Organization Actin Filament-based Process ATP Binding Regulation Of Organelle Organization Regulation Of Cellular Component Organization Nucleotide Binding Focal Adhesion Protein Modification Process Cytoplasm Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Localization Regulation Of Supramolecular Fiber Organization Protein Kinase Activity Regulation Of Multicellular Organismal Process Actin Filament Cytoskeleton Positive Regulation Of Multicellular Organismal Process Mesenchyme Migration Regulation Of Protein Localization To Nucleus Cytoskeleton Organization Regulation Of Membrane Potential Developmental Process Protein Phosphorylation Cell Junction Organization ERBB2 Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Actin Filament Organization Kinase Activity Protein-containing Complex Lamellipodium Regulation Of Actin Filament-based Process Anatomical Structure Morphogenesis Phosphorylation Organelle Organization Positive Regulation Of Cell Activation Protein Tyrosine Kinase Activity Regulation Of Macromolecule Biosynthetic Process Phosphatase Activity Positive Regulation Of Signaling Negative Regulation Of Apoptotic Process Intracellular Signal Transduction Negative Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Protein Localization To Cell Junction Positive Regulation Of MAPK Cascade Negative Regulation Of Programmed Cell Death Regulation Of Actin Cytoskeleton Organization Protein Serine/threonine Phosphatase Activity	Symbiont Entry Into Host Cell Biological Process Involved In Interaction With Host Cofilin-actin Rod Cell Leading Edge Negative Regulation Of Unidimensional Cell Growth Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Positive Regulation Of Barbed-end Actin Filament Capping Positive Regulation Of Protein Localization To Cell Leading Edge C-X-C Motif Chemokine 12 Receptor Activity Anchoring Junction Ubiquitin Ligase Complex Negative Regulation Of Postsynaptic Density Organization Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Regulation Of Protein Localization To Cell Leading Edge Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Regulation Of Cell Adhesion Extracellular Exosome Neural Fold Formation Actin Filament Fragmentation Negative Regulation Of Dendritic Spine Maintenance Regulation Of Barbed-end Actin Filament Capping Cell-cell Junction Negative Regulation Of Lamellipodium Assembly CXCL12-activated CXCR4 Signaling Pathway Negative Regulation Of Potassium Ion Export Across Plasma Membrane Myosin Light Chain Binding C-X-C Chemokine Receptor CXCR4 Signaling Pathway Ubiquitin-protein Transferase Activity Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway C-X-C Chemokine Receptor Activity Negative Regulation Of Cell Size Positive Regulation Of Synaptic Plasticity Potassium Channel Inhibitor Activity Positive Regulation Of Actin Filament Depolymerization Cellular Response To Insulin-like Growth Factor Stimulus Cellular Response To Ether Actin Filament Depolymerization Modification Of Postsynaptic Actin Cytoskeleton Phosphatidylinositol Bisphosphate Binding Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Dendritic Spine Maintenance Actin Filament Severing Endothelial Cell Morphogenesis Ubiquitin Protein Ligase Activity Morphogenesis Of An Epithelial Fold Myelin Maintenance Alpha-actinin Binding Actin Binding Cellular Response To Interleukin-6 Response To Virus
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