CFL1 and HSPH1

Number of citations of the paper that reports this interaction (PMID 14733918)
1

Data Source:
HPRD (in vitro)

		CFL1	HSPH1
Gene Name		cofilin 1 (non-muscle)	heat shock 105kDa/110kDa protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cell-cell Junction Focal Adhesion Membrane Nuclear Matrix Cortical Actin Cytoskeleton Lamellipodium Membrane Vesicle Ruffle Membrane Extracellular Vesicular Exosome	Extracellular Region Nucleoplasm Cytoplasm Cytosol Microtubule Extracellular Vesicular Exosome Endocytic Vesicle Lumen
	Molecular Function	Actin Binding Protein Binding	Protein Binding ATP Binding Alpha-tubulin Binding
	Biological Process	Mitotic Cytokinesis Neural Crest Cell Migration Neural Fold Formation Platelet Degranulation Protein Phosphorylation Protein Import Into Nucleus Cytoskeleton Organization Rho Protein Signal Transduction Axon Guidance Blood Coagulation Response To Virus Regulation Of Cell Morphogenesis Establishment Of Cell Polarity Actin Cytoskeleton Organization Actin Filament Depolymerization Platelet Activation Positive Regulation Of Actin Filament Depolymerization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Apoptotic Process Response To Amino Acid Innate Immune Response Negative Regulation Of Cell Size Ephrin Receptor Signaling Pathway Regulation Of Dendritic Spine Morphogenesis	Receptor-mediated Endocytosis Response To Unfolded Protein Positive Regulation Of MHC Class I Biosynthetic Process Chaperone Mediated Protein Folding Requiring Cofactor Positive Regulation Of NK T Cell Activation
Pathways		Axon guidance Semaphorin interactions Platelet degranulation EPHB-mediated forward signaling Response to elevated platelet cytosolic Ca2+ Sema3A PAK dependent Axon repulsion EPH-Ephrin signaling Platelet activation, signaling and aggregation Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System	Scavenging by Class F Receptors
Drugs
Diseases
GWAS		Breast cancer ( 23535729) DNA methylation (variation) ( 23725790)
Protein-Protein Interactions		37 interactors: ACTA1 ACTA2 ACTB ACTC1 ACTG1 APP ATP1A1 ATXN1 CFL2 CLCN5 EGFR HSPH1 LIMK1 LIMK2 MAPK6 MAPK8IP2 MYCBP NRK POT1 PSEN1 RAD21 RPS6KA1 SLC2A4 SRC SSH1 SSH2 SSH3 TAB1 TERF1 TESK1 TESK2 TPI1 UCHL5 WDR1 YWHAG YWHAQ YWHAZ	14 interactors: ADD1 CFL1 CHD3 CSNK2A1 CSNK2A2 DYNLRB1 HSPA8 PAFAH1B1 PAFAH1B3 PGK1 STK39 TUBA4A UBA1 VAV2
Entrez ID		1072	10808
HPRD ID		03261	09990
Ensembl ID		ENSG00000172757	ENSG00000120694
Uniprot IDs		P23528	B4DYH1 Q92598
PDB IDs		1Q8G 1Q8X 3J0S 4BEX
Enriched GO Terms of Interacting Partners?		Generation Of Neurons Neurogenesis Developmental Process Nervous System Development System Development Multicellular Organismal Development Phosphate-containing Compound Metabolic Process Regulation Of Organelle Organization Cell Differentiation Positive Regulation Of Organelle Organization Anatomical Structure Development Actin Cytoskeleton Organization Cellular Component Assembly Actin Filament-based Process Immune Response-regulating Signaling Pathway Platelet Activation Actomyosin Structure Organization Regulation Of Neurogenesis Anatomical Structure Morphogenesis MAPK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Neuron Differentiation Cell Development Response To Stimulus Axon Guidance Phosphorylation Negative Regulation Of Catalytic Activity Cell Morphogenesis Involved In Neuron Differentiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Cellular Component Organization Fc Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Response To Stress Homeostatic Process Regulation Of Axonogenesis Regulation Of Cell Development Signal Transduction By Phosphorylation Neuron Projection Morphogenesis Organelle Organization Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Myofibril Assembly Cell Activation Regulation Of Lamellipodium Assembly Regulation Of Cell Projection Organization Neuron Development Adherens Junction Organization Cell Morphogenesis Involved In Differentiation Regulation Of Protein Metabolic Process Apoptotic Process	Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Axon Guidance Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Movement Of Cell Or Subcellular Component Neuron Development Cell Cycle Process Chemotaxis Neuron Differentiation Cell Projection Organization Mitotic Cell Cycle Process Locomotion Mitotic Cell Cycle Cell Cycle Nervous System Development Generation Of Neurons Secretion By Cell Platelet Activation Anatomical Structure Morphogenesis Neurogenesis Cell Differentiation Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Cytoskeleton Organization Cell Development Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint 'de Novo' Posttranslational Protein Folding Secretion Regulation Of Mitotic Metaphase/anaphase Transition 'de Novo' Protein Folding Anatomical Structure Development Regulation Of Cellular Component Organization Chaperone-mediated Protein Folding Protein Folding Negative Regulation Of Fibril Organization Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Actin Filament Depolymerization Platelet Degranulation Microtubule-based Process Regulation Of Cellular Component Size Negative Regulation Of Cellular Protein Catabolic Process
Tagcloud ?		anxa4 cacybp ciapin1 ctro cytokinesis fam50a hspb1 incapable mefs migrated nbs ndrg ndrg1 ndrg1expression nsfl1c pcbp2 pdap1 pml proliferate proliferated relay rsu1 stations stmn1 sumo2 tpd52l2 trio ube2m ywhag	accordingly aggressive aggressiveness bcl candidacy clarify concurrently confirming delay favors hodgkin injected interacts lymphoma lymphomas myc namalwa nhl nhls oncoproteins paralleled physically positively silenced stabilization tumorigenicity valuable
Tagcloud (Difference) ?		anxa4 cacybp ciapin1 ctro cytokinesis fam50a hspb1 incapable mefs migrated nbs ndrg ndrg1 ndrg1expression nsfl1c pcbp2 pdap1 pml proliferate proliferated relay rsu1 stations stmn1 sumo2 tpd52l2 trio ube2m ywhag	accordingly aggressive aggressiveness bcl candidacy clarify concurrently confirming delay favors hodgkin injected interacts lymphoma lymphomas myc namalwa nhl nhls oncoproteins paralleled physically positively silenced stabilization tumorigenicity valuable
Tagcloud (Intersection) ?