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CFL1 and UCHL5
Number of citations of the paper that reports this interaction (PMID
21800051
)
0
Data Source:
BioGRID
(pull down)
CFL1
UCHL5
Gene Name
cofilin 1 (non-muscle)
ubiquitin carboxyl-terminal hydrolase L5
Image
Gene Ontology Annotations
Cellular Component
Extracellular Space
Nucleus
Cytoplasm
Cell-cell Junction
Focal Adhesion
Membrane
Nuclear Matrix
Cortical Actin Cytoskeleton
Lamellipodium Membrane
Vesicle
Ruffle Membrane
Extracellular Vesicular Exosome
Proteasome Complex
Nucleus
Cytosol
Ino80 Complex
Molecular Function
Actin Binding
Protein Binding
Ubiquitin-specific Protease Activity
Endopeptidase Inhibitor Activity
Protein Binding
Omega Peptidase Activity
Poly(A) RNA Binding
Proteasome Binding
Biological Process
Mitotic Cytokinesis
Neural Crest Cell Migration
Neural Fold Formation
Platelet Degranulation
Protein Phosphorylation
Protein Import Into Nucleus
Cytoskeleton Organization
Rho Protein Signal Transduction
Axon Guidance
Blood Coagulation
Response To Virus
Regulation Of Cell Morphogenesis
Establishment Of Cell Polarity
Actin Cytoskeleton Organization
Actin Filament Depolymerization
Platelet Activation
Positive Regulation Of Actin Filament Depolymerization
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Negative Regulation Of Apoptotic Process
Response To Amino Acid
Innate Immune Response
Negative Regulation Of Cell Size
Ephrin Receptor Signaling Pathway
Regulation Of Dendritic Spine Morphogenesis
DNA Repair
DNA Recombination
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Ubiquitin-dependent Protein Catabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Endopeptidase Activity
Protein Deubiquitination
Lateral Ventricle Development
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Midbrain Development
Forebrain Morphogenesis
Regulation Of Proteasomal Protein Catabolic Process
Pathways
Axon guidance
Semaphorin interactions
Platelet degranulation
EPHB-mediated forward signaling
Response to elevated platelet cytosolic Ca2+
Sema3A PAK dependent Axon repulsion
EPH-Ephrin signaling
Platelet activation, signaling and aggregation
Fcgamma receptor (FCGR) dependent phagocytosis
Regulation of actin dynamics for phagocytic cup formation
Innate Immune System
Loss of Function of TGFBR2 in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
Downregulation of TGF-beta receptor signaling
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
TGF-beta receptor signaling activates SMADs
TGFBR1 LBD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Breast cancer (
23535729
)
DNA methylation (variation) (
23725790
)
Cannabis dependence (
21668797
)
Protein-Protein Interactions
37 interactors:
ACTA1
ACTA2
ACTB
ACTC1
ACTG1
APP
ATP1A1
ATXN1
CFL2
CLCN5
EGFR
HSPH1
LIMK1
LIMK2
MAPK6
MAPK8IP2
MYCBP
NRK
POT1
PSEN1
RAD21
RPS6KA1
SLC2A4
SRC
SSH1
SSH2
SSH3
TAB1
TERF1
TESK1
TESK2
TPI1
UCHL5
WDR1
YWHAG
YWHAQ
YWHAZ
96 interactors:
ACTN4
ADRM1
ANP32B
ANP32E
ANXA1
ANXA4
ANXA7
ANXA8
APP
ARG1
ASPRV1
CALM1
CAP1
CAPZA1
CASP14
CDSN
CFL1
CSTA
DSC1
DSC3
DSP
DUSP14
EEF1G
EEF2
EIF4A1
EPPK1
FLG
GSTM3
HAUS7
HBA1
HBA2
HBB
HIST1H4A
HIST1H4B
HIST1H4C
HIST1H4D
HIST1H4E
HIST1H4F
HIST1H4H
HIST1H4I
HIST1H4J
HIST1H4K
HIST1H4L
HIST2H4A
HIST2H4B
HIST4H4
HSPB1
IDE
IGHG1
IVL
KDM1A
KRT12
KRT19
KRT26
KRT28
KRT73
KRT78
KRT80
LMNA
NACA
NFRKB
PJA1
PKM
PKP1
PLA2G2A
PNP
POF1B
PRDX6
PSMD8
RAB7A
RBCK1
RFFL
S100A14
S100A16
S100A7
SERPINB12
SERPINB3
SERPINB5
SET
SMAD2
SMAD3
SMAD7
TGM3
TPI1
TRIM27
TRIM46
TRIM54
TRIM55
TRIM63
TUBA4A
TXN
TXN2
UBE3A
USP28
YWHAZ
ZBED1
Entrez ID
1072
51377
HPRD ID
03261
10293
Ensembl ID
ENSG00000172757
ENSG00000116750
Uniprot IDs
P23528
Q9Y5K5
PDB IDs
1Q8G
1Q8X
3J0S
4BEX
3A7S
3IHR
3RII
3RIS
3TB3
Enriched GO Terms of Interacting Partners
?
Generation Of Neurons
Neurogenesis
Developmental Process
Nervous System Development
System Development
Multicellular Organismal Development
Phosphate-containing Compound Metabolic Process
Regulation Of Organelle Organization
Cell Differentiation
Positive Regulation Of Organelle Organization
Anatomical Structure Development
Actin Cytoskeleton Organization
Cellular Component Assembly
Actin Filament-based Process
Immune Response-regulating Signaling Pathway
Platelet Activation
Actomyosin Structure Organization
Regulation Of Neurogenesis
Anatomical Structure Morphogenesis
MAPK Cascade
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Neuron Differentiation
Cell Development
Response To Stimulus
Axon Guidance
Phosphorylation
Negative Regulation Of Catalytic Activity
Cell Morphogenesis Involved In Neuron Differentiation
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Regulation Of Cellular Component Organization
Fc Receptor Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Response To Stress
Homeostatic Process
Regulation Of Axonogenesis
Regulation Of Cell Development
Signal Transduction By Phosphorylation
Neuron Projection Morphogenesis
Organelle Organization
Negative Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Myofibril Assembly
Cell Activation
Regulation Of Lamellipodium Assembly
Regulation Of Cell Projection Organization
Neuron Development
Adherens Junction Organization
Cell Morphogenesis Involved In Differentiation
Regulation Of Protein Metabolic Process
Apoptotic Process
Histone H4-K20 Demethylation
Negative Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Hematopoietic Progenitor Cell Differentiation
DNA Replication-dependent Nucleosome Assembly
Regulation Of Megakaryocyte Differentiation
DNA Methylation On Cytosine
Chromatin Silencing At RDNA
Regulation Of Hematopoietic Progenitor Cell Differentiation
Histone Exchange
Histone Lysine Demethylation
Histone Demethylation
Protein Demethylation
CENP-A Containing Nucleosome Assembly
Chromatin Silencing
DNA Replication-independent Nucleosome Assembly
Demethylation
Centromere Complex Assembly
ATP-dependent Chromatin Remodeling
Negative Regulation Of Gene Expression, Epigenetic
Gene Silencing
DNA Methylation
Nucleosome Organization
Nucleosome Assembly
Chromatin Assembly
Telomere Maintenance
Negative Regulation Of Myeloid Cell Differentiation
DNA Modification
Chromatin Assembly Or Disassembly
Protein-DNA Complex Assembly
Protein Complex Assembly
Regulation Of Gene Expression, Epigenetic
DNA Packaging
Cellular Component Assembly
Regulation Of Myeloid Cell Differentiation
DNA Conformation Change
Chromatin Remodeling
Negative Regulation Of Cellular Metabolic Process
Regulation Of Immune System Process
Cellular Macromolecular Complex Assembly
Negative Regulation Of Cell Differentiation
Mitotic Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Immune System Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Histone Modification
Negative Regulation Of Gene Expression
Keratinocyte Differentiation
Cellular Protein Metabolic Process
Homeostatic Process
Tagcloud
?
anxa4
cacybp
ciapin1
ctro
cytokinesis
fam50a
hspb1
incapable
mefs
migrated
nbs
ndrg
ndrg1
ndrg1expression
nsfl1c
pcbp2
pdap1
pml
proliferate
proliferated
relay
rsu1
stations
stmn1
sumo2
tpd52l2
trio
ube2m
ywhag
Tagcloud (Difference)
?
anxa4
cacybp
ciapin1
ctro
cytokinesis
fam50a
hspb1
incapable
mefs
migrated
nbs
ndrg
ndrg1
ndrg1expression
nsfl1c
pcbp2
pdap1
pml
proliferate
proliferated
relay
rsu1
stations
stmn1
sumo2
tpd52l2
trio
ube2m
ywhag
Tagcloud (Intersection)
?