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BTK and KHDRBS1
Number of citations of the paper that reports this interaction (PubMedID
9201297
)
0
Data Source:
HPRD
(in vivo)
BTK
KHDRBS1
Description
Bruton tyrosine kinase
KH RNA binding domain containing, signal transduction associated 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Cytoplasmic Vesicle
Membrane Raft
Perinuclear Region Of Cytoplasm
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Membrane
Protein-containing Complex
Grb2-Sos Complex
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Phosphatidylinositol-3,4,5-trisphosphate Binding
Zinc Ion Binding
Lipid Binding
Phospholipase Activator Activity
Kinase Activity
Transferase Activity
Identical Protein Binding
Phospholipase Binding
Metal Ion Binding
Nucleic Acid Binding
DNA Binding
RNA Binding
MRNA Binding
Protein Binding
Poly(A) Binding
Poly(U) RNA Binding
SH3 Domain Binding
Protein Domain Specific Binding
Signaling Adaptor Activity
SH2 Domain Binding
Identical Protein Binding
Protein-containing Complex Binding
Molecular Function Inhibitor Activity
Protein Tyrosine Kinase Binding
Biological Process
Neutrophil Homeostasis
Positive Regulation Of Type III Hypersensitivity
Positive Regulation Of Type I Hypersensitivity
Negative Regulation Of Cytokine Production
Adaptive Immune Response
B Cell Affinity Maturation
Immune System Process
Histamine Secretion By Mast Cell
Positive Regulation Of Immunoglobulin Production
Regulation Of B Cell Cytokine Production
MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of B Cell Apoptotic Process
Apoptotic Process
Mesoderm Development
Peptidyl-tyrosine Phosphorylation
Calcium-mediated Signaling
Proteoglycan Catabolic Process
Negative Regulation Of B Cell Proliferation
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Type I Interferon Production
Response To Lipopolysaccharide
Negative Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Cellular Response To Reactive Oxygen Species
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
B Cell Activation
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Positive Regulation Of B Cell Differentiation
Cell Maturation
Positive Regulation Of Phagocytosis
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Regulation Of B Cell Activation
Negative Regulation Of B Cell Activation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Monocyte Proliferation
Negative Regulation Of Leukocyte Proliferation
Cellular Response To Molecule Of Fungal Origin
Apoptotic Signaling Pathway
Cellular Response To Interleukin-7
CGAS/STING Signaling Pathway
Positive Regulation Of CGAS/STING Signaling Pathway
Positive Regulation Of Interleukin-17A Production
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Positive Regulation Of Synoviocyte Proliferation
Eosinophil Homeostasis
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Alternative MRNA Splicing, Via Spliceosome
MRNA Processing
Cell Surface Receptor Signaling Pathway
Spermatogenesis
Regulation Of Protein Stability
Regulation Of Apoptotic Process
Regulation Of RNA Splicing
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Translational Initiation
Regulation Of RNA Export From Nucleus
Positive Regulation Of RNA Export From Nucleus
Regulation Of MRNA Splicing, Via Spliceosome
T Cell Receptor Signaling Pathway
Regulation Of Cell Cycle
Pathways
ER-Phagosome pathway
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Regulation of actin dynamics for phagocytic cup formation
DAP12 signaling
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
G alpha (q) signalling events
G alpha (12/13) signalling events
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
RHO GTPases Activate WASPs and WAVEs
G beta:gamma signalling through BTK
FCGR3A-mediated phagocytosis
Potential therapeutics for SARS
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
PTK6 Regulates Proteins Involved in RNA Processing
Drugs
Dasatinib
Inositol 1,3,4,5-Tetrakisphosphate
XL418
Ibrutinib
Acalabrutinib
Spebrutinib
Fostamatinib
Fenebrutinib
Zanubrutinib
Evobrutinib
Tirabrutinib
Abivertinib
Branebrutinib
Vecabrutinib
Diseases
Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS
Body mass index (
26426971
)
Interacting Genes
77 interacting genes:
ABL1
APP
AR
ARHGAP17
ARID3A
ARRB1
AURKA
BCL2L11
BECN1
BLNK
BMX
CAV1
CBL
CD19
CMTM3
COASY
CPVL
DAPP1
ERBB3
EWSR1
FAS
FASLG
FYN
GAB1
GNA12
GNAQ
GNG2
GTF2I
HCK
IBTK
IRAK1
ITK
JAK1
KHDRBS1
KIT
LYN
MDM2
MEOX2
MET
MRPS22
MYD88
PIK3AP1
PIK3R3
PIP4K2A
PIP4K2B
PIP4K2C
PIP5K1A
PIP5K1B
PIP5K1C
PLAU
PLCG1
PLCG2
PRKCA
PRKCB
PRKCE
PRKCQ
PRKCZ
PRKD1
RELA
RPS6KB1
RPS6KB2
SH2B2
SH3BP5
SMURF1
STAT5A
SYK
TEC
TIRAP
TLR4
TLR6
TLR8
TLR9
TNFRSF10A
TP53
VAV1
WAS
WASF2
116 interacting genes:
ABI2
ACTB
AGO1
AHI1
AMPH
APBB1
ARHGEF4
ARHGEF9
AZIN1
BAIAP2L1
BTK
CBL
CD2AP
CDC42
CDK1
CEBPA
CIRBP
CLK1
CREB3L3
CREBBP
CRK
CRKL
CSK
DDX5
DHX9
DLG1
DLG2
DLG3
DLG4
DNMBP
DOCK2
DOCK3
DSCAM
EFEMP1
EMG1
FGR
FNBP4
FRK
FXR1
FXR2
FYN
GAS7
GPHN
GRAP
GRAP2
GRB2
HCK
HNRNPK
INSR
ITK
ITPRID2
ITSN1
ITSN2
JAK3
KHDRBS3
LCK
LYN
MAPK1
MYO1C
MYO7A
NCF1
NCK1
NCK2
NCKIPSD
NPHP1
OGT
OSTF1
PACSIN1
PALS2
PIK3R1
PIK3R3
PLCG1
PLCG2
POT1
PPP1R13B
PRMT1
PSTPIP1
PTBP2
PTK6
PTPN6
RALY
RAPSN
RASA1
RBFOX2
RBM7
RUSC2
SASH1
SCG5
SH3PXD2A
SH3YL1
SHANK3
SKAP2
SMAD2
SMARCA2
SNX30
SNX9
SORBS1
SPATA13
SRC
SRPK2
STAT3
STUB1
TBL1X
TJP1
TSPOAP1
TUBB3
UBA52
UBASH3B
UBC
USP7
VAV1
WBP4
YES1
YTHDC1
ZBTB7A
ZDHHC6
Entrez ID
695
10657
HPRD ID
02248
03926
Ensembl ID
ENSG00000010671
ENSG00000121774
Uniprot IDs
Q06187
Q5JY90
Q07666
PDB IDs
1AWW
1AWX
1B55
1BTK
1BWN
1K2P
1QLY
2GE9
2Z0P
3GEN
3K54
3OCS
3OCT
3P08
3PIX
3PIY
3PIZ
3PJ1
3PJ2
3PJ3
4NWM
4OT5
4OT6
4OTF
4OTQ
4OTR
4RFY
4RFZ
4RG0
4RX5
4YHF
4Z3V
4ZLY
4ZLZ
5BPY
5BQ0
5FBN
5FBO
5J87
5JRS
5KUP
5P9F
5P9G
5P9H
5P9I
5P9J
5P9K
5P9L
5P9M
5T18
5U9D
5VFI
5VGO
5XYZ
5ZZ4
6AUA
6AUB
6BIK
6BKE
6BKH
6BKW
6BLN
6DI0
6DI1
6DI3
6DI5
6DI9
6E4F
6EP9
6HRP
6HRT
6HTF
6J6M
6N9P
6NFH
6NFI
6NZM
6O8I
6OMU
6S90
6TFP
6TSE
6TT2
6TUH
6TVN
6VXQ
6W06
6W07
6W7O
6W8I
6X3N
6X3O
6X3P
6XE4
6YYF
6YYG
6YYK
7KXL
7KXM
7KXN
7KXO
7KXP
7KXQ
7L5O
7L5P
7LTY
7LTZ
7N4Q
7N4R
7N4S
7N5O
7N5R
7N5X
7N5Y
7R60
7R61
7YC9
8DSO
8E2M
8EJB
8FLG
8FLH
8FLL
8FLN
8FLV
8GC7
8GC8
8TU3
8TU4
8TU5
8U2D
8U2E
8YVV
2XA6
3QHE
7Z89
7Z8A
7Z9A
7Z9B
7ZAB
7ZAC
7ZAF
7ZAM
Enriched GO Terms of Interacting Partners
?
Immune Response-regulating Signaling Pathway
Signal Transduction
Immune Response-activating Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Activation Of Immune Response
Positive Regulation Of Immune Response
Cell Surface Receptor Signaling Pathway
Intracellular Signal Transduction
Positive Regulation Of Immune System Process
Regulation Of Immune Response
Kinase Activity
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Plasma Membrane
Positive Regulation Of Intracellular Signal Transduction
Immune System Process
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Immune System Process
Positive Regulation Of Signal Transduction
Innate Immune Response-activating Signaling Pathway
Activation Of Innate Immune Response
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Innate Immune Response
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Protein Kinase Activity
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
B Cell Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Fc Receptor Signaling Pathway
Intracellular Signaling Cassette
Leukocyte Activation
Cytoplasm
Antigen Receptor-mediated Signaling Pathway
Regulation Of Innate Immune Response
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Cellular Component Biogenesis
Cell Activation
Regulation Of Programmed Cell Death
Positive Regulation Of Defense Response
Positive Regulation Of Metabolic Process
Toll-like Receptor Signaling Pathway
Positive Regulation Of Gene Expression
Cell Surface Pattern Recognition Receptor Signaling Pathway
Response To Lipid
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Phosphotyrosine Residue Binding
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Non-membrane Spanning Protein Tyrosine Kinase Activity
Cytosol
Cytoplasm
Intracellular Signal Transduction
Immune Response-activating Cell Surface Receptor Signaling Pathway
Peptidyl-tyrosine Phosphorylation
Cell-cell Junction
Signal Transduction
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Protein Tyrosine Kinase Activity
Immune Response-activating Signaling Pathway
Positive Regulation Of Cellular Component Organization
Regulation Of Cellular Component Organization
Fc Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
SH3 Domain Binding
Protein Binding
Activation Of Immune Response
Regulation Of Intracellular Signal Transduction
Antigen Receptor-mediated Signaling Pathway
Plasma Membrane
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Signal Transduction
T Cell Receptor Signaling Pathway
T Cell Costimulation
Regulation Of Endocytosis
Fc-gamma Receptor Signaling Pathway
Intracellular Signaling Cassette
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Phosphorylation
Regulation Of Transport
Protein Phosphorylation
Fc Receptor Mediated Stimulatory Signaling Pathway
Ephrin Receptor Binding
Positive Regulation Of Immune Response
Regulation Of Immune System Process
Positive Regulation Of Immune System Process
Regulation Of Vesicle-mediated Transport
Developmental Process
Regulation Of Immune Response
Immune System Process
Ionotropic Glutamate Receptor Binding
Endocytosis
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Ephrin Receptor Signaling Pathway
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Tagcloud (Intersection)
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