BTK and PIP5K1B

Number of citations of the paper that reports this interaction (PMID 14614850)
4

Data Source:
HPRD (in vitro, in vivo)

		BTK	PIP5K1B
Gene Name		Bruton agammaglobulinemia tyrosine kinase	phosphatidylinositol-4-phosphate 5-kinase, type I, beta
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle Mast Cell Granule Intracellular Membrane-bounded Organelle Membrane Raft Perinuclear Region Of Cytoplasm	Uropod Cytosol Endomembrane System Membrane
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Identical Protein Binding Metal Ion Binding	Protein Binding ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity
	Biological Process	Toll-like Receptor Signaling Pathway Adaptive Immune Response Histamine Secretion By Mast Cell Regulation Of B Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of B Cell Apoptotic Process Transcription, DNA-templated Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Mesoderm Development Calcium-mediated Signaling Cell Differentiation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Response To Reactive Oxygen Species Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway B Cell Activation Regulation Of Cell Proliferation Innate Immune Response Positive Regulation Of B Cell Differentiation Cell Maturation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Molecule Of Fungal Origin Apoptotic Signaling Pathway	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation
Pathways		Signaling by the B Cell Receptor (BCR) DAP12 interactions Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade DAP12 signaling Activated TLR4 signalling Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling MyD88:Mal cascade initiated on plasma membrane FCERI mediated Ca+2 mobilization Fcgamma receptor (FCGR) dependent phagocytosis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Regulation of actin dynamics for phagocytic cup formation Adaptive Immune System Innate Immune System	Synthesis of PIPs at the plasma membrane WNT mediated activation of DVL Metabolism of lipids and lipoproteins misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Phospholipid metabolism Signaling by Wnt Signaling by WNT in cancer PI Metabolism
Drugs		Inositol 1,3,4,5-Tetrakisphosphate
Diseases
GWAS			Body mass index (interaction) ( 23192594) Chronic kidney disease ( 20383146)
Protein-Protein Interactions		64 interactors: ABL1 APP ARHGAP17 ARID3A ARRB1 BCL2L11 BLNK BMX CAV1 CBL CD19 CMTM3 DAPP1 EWSR1 FAS FASLG FYN GNA12 GNAQ GNG2 GTF2I HCK IBTK IRAK1 ITK JAK1 KHDRBS1 KIT LYN MYD88 PIK3AP1 PIP4K2A PIP4K2B PIP4K2C PIP5K1A PIP5K1B PIP5K1C PLAU PLCG1 PLCG2 PRKCA PRKCB PRKCE PRKCQ PRKCZ PRKD1 RELA RPS6KB1 RPS6KB2 SH2B2 SH3BP5 STAT5A SYK TEC TIRAP TLR4 TLR6 TLR8 TLR9 TNFRSF10A TP53 VAV1 WAS WASF2	2 interactors: BTK PIP5KL1
Entrez ID		695	8395
HPRD ID		02248	04121
Ensembl ID		ENSG00000010671	ENSG00000107242
Uniprot IDs		Q06187 Q5JY90	B4DIG7 O14986 Q7KYT6
PDB IDs		1AWW 1AWX 1B55 1BTK 1BWN 1K2P 1QLY 2GE9 2Z0P 3GEN 3K54 3OCS 3OCT 3P08 3PIX 3PIY 3PIZ 3PJ1 3PJ2 3PJ3
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Signaling Pathway Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Immune System Process Signaling Cell Surface Receptor Signaling Pathway Cell Communication Regulation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Innate Immune Response Immune Response Cellular Response To Stimulus Blood Coagulation Hemostasis Cell Activation Response To Stress Defense Response Positive Regulation Of Signal Transduction Regulation Of Body Fluid Levels Wound Healing Regulation Of Signal Transduction Response To Wounding Positive Regulation Of Intracellular Signal Transduction Response To External Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Response To Stimulus Fc Receptor Signaling Pathway Regulation Of Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Platelet Activation Regulation Of Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway Response To Organic Substance Phosphorylation Cellular Response To Organic Substance Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Metabolic Process Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cytokine Biosynthetic Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Leukocyte Activation Protein Autophosphorylation	Regulation Of B Cell Cytokine Production Cellular Response To Molecule Of Fungal Origin Response To Molecule Of Fungal Origin Histamine Secretion By Mast Cell Histamine Secretion Positive Regulation Of B Cell Differentiation Histamine Transport Regulation Of B Cell Apoptotic Process Mast Cell Degranulation Production Of Molecular Mediator Involved In Inflammatory Response Regulation Of B Cell Differentiation Mast Cell Mediated Immunity Lysosome Localization Mast Cell Activation Peptidyl-tyrosine Autophosphorylation B Cell Receptor Signaling Pathway Response To Fungus Leukocyte Degranulation Regulated Secretory Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Regulation Of Lymphocyte Apoptotic Process MyD88-dependent Toll-like Receptor Signaling Pathway Ammonium Transport Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of B Cell Activation Phosphorylation Toll-like Receptor 4 Signaling Pathway Hormone Secretion Phosphatidylinositol Phosphorylation Lipid Phosphorylation Hormone Transport Calcium-mediated Signaling Positive Regulation Of Lymphocyte Differentiation Cellular Response To Reactive Oxygen Species Toll-like Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Antigen Receptor-mediated Signaling Pathway Second-messenger-mediated Signaling Activation Of Innate Immune Response Mesoderm Development Cell Maturation Regulation Of Lymphocyte Differentiation Leukocyte Activation Involved In Immune Response B Cell Activation Phosphate-containing Compound Metabolic Process
Tagcloud ?		adhesion allergic appear asthma compares contrasts csf degranulation describes emerging eosinophil eosinophils exert gm granulocyte hematopoiesis heterodimer jak lyn macrophage paramount propagates raf segregation seminal shp stat syk transduction	affects ca1 ca3 cdna dentate differentially downregulated downregulation glutathione granular grb2 gstp2 gyrus help hippocampal hippocampus hybridization layer microarrays occurrence phosphate phosphatidylinositol pi2 pyramidal restraint reverse subjected transferase understand
Tagcloud (Difference) ?		adhesion allergic appear asthma compares contrasts csf degranulation describes emerging eosinophil eosinophils exert gm granulocyte hematopoiesis heterodimer jak lyn macrophage paramount propagates raf segregation seminal shp stat syk transduction	affects ca1 ca3 cdna dentate differentially downregulated downregulation glutathione granular grb2 gstp2 gyrus help hippocampal hippocampus hybridization layer microarrays occurrence phosphate phosphatidylinositol pi2 pyramidal restraint reverse subjected transferase understand
Tagcloud (Intersection) ?