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BTK and IBTK
Number of citations of the paper that reports this interaction (PMID
11577348
)
10
Data Source:
HPRD
(in vitro, two hybrid, in vivo)
BTK
IBTK
Gene Name
Bruton agammaglobulinemia tyrosine kinase
inhibitor of Bruton agammaglobulinemia tyrosine kinase
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Cytoplasmic Vesicle
Mast Cell Granule
Intracellular Membrane-bounded Organelle
Membrane Raft
Perinuclear Region Of Cytoplasm
Nucleoplasm
Cytoplasm
Membrane
Molecular Function
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Receptor Binding
Protein Binding
ATP Binding
Phosphatidylinositol-3,4,5-trisphosphate Binding
Identical Protein Binding
Metal Ion Binding
Protein Kinase Binding
Protein Tyrosine Kinase Inhibitor Activity
Biological Process
Toll-like Receptor Signaling Pathway
Adaptive Immune Response
Histamine Secretion By Mast Cell
Regulation Of B Cell Cytokine Production
MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of B Cell Apoptotic Process
Transcription, DNA-templated
Protein Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
Mesoderm Development
Calcium-mediated Signaling
Cell Differentiation
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Cellular Response To Reactive Oxygen Species
Intracellular Signal Transduction
Peptidyl-tyrosine Autophosphorylation
Fc-epsilon Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
B Cell Activation
Regulation Of Cell Proliferation
Innate Immune Response
Positive Regulation Of B Cell Differentiation
Cell Maturation
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Cellular Response To Molecule Of Fungal Origin
Apoptotic Signaling Pathway
Negative Regulation Of Protein Phosphorylation
Release Of Sequestered Calcium Ion Into Cytosol
Negative Regulation Of Protein Tyrosine Kinase Activity
Pathways
Signaling by the B Cell Receptor (BCR)
DAP12 interactions
Toll Like Receptor TLR6:TLR2 Cascade
Toll Like Receptor 2 (TLR2) Cascade
Toll Like Receptor TLR1:TLR2 Cascade
DAP12 signaling
Activated TLR4 signalling
Toll-Like Receptors Cascades
Toll Like Receptor 4 (TLR4) Cascade
Fc epsilon receptor (FCERI) signaling
MyD88:Mal cascade initiated on plasma membrane
FCERI mediated Ca+2 mobilization
Fcgamma receptor (FCGR) dependent phagocytosis
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Regulation of actin dynamics for phagocytic cup formation
Adaptive Immune System
Innate Immune System
Drugs
Inositol 1,3,4,5-Tetrakisphosphate
Diseases
GWAS
Corneal structure (
23291589
)
Protein-Protein Interactions
64 interactors:
ABL1
APP
ARHGAP17
ARID3A
ARRB1
BCL2L11
BLNK
BMX
CAV1
CBL
CD19
CMTM3
DAPP1
EWSR1
FAS
FASLG
FYN
GNA12
GNAQ
GNG2
GTF2I
HCK
IBTK
IRAK1
ITK
JAK1
KHDRBS1
KIT
LYN
MYD88
PIK3AP1
PIP4K2A
PIP4K2B
PIP4K2C
PIP5K1A
PIP5K1B
PIP5K1C
PLAU
PLCG1
PLCG2
PRKCA
PRKCB
PRKCE
PRKCQ
PRKCZ
PRKD1
RELA
RPS6KB1
RPS6KB2
SH2B2
SH3BP5
STAT5A
SYK
TEC
TIRAP
TLR4
TLR6
TLR8
TLR9
TNFRSF10A
TP53
VAV1
WAS
WASF2
5 interactors:
BTK
LAMTOR3
PPP1CA
PRKCB
PRKD1
Entrez ID
695
25998
HPRD ID
02248
12105
Ensembl ID
ENSG00000010671
ENSG00000005700
Uniprot IDs
Q06187
Q5JY90
Q9P2D0
PDB IDs
1AWW
1AWX
1B55
1BTK
1BWN
1K2P
1QLY
2GE9
2Z0P
3GEN
3K54
3OCS
3OCT
3P08
3PIX
3PIY
3PIZ
3PJ1
3PJ2
3PJ3
Enriched GO Terms of Interacting Partners
?
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Immune Response-regulating Signaling Pathway
Intracellular Signal Transduction
Enzyme Linked Receptor Protein Signaling Pathway
Signal Transduction
Immune System Process
Signaling
Cell Surface Receptor Signaling Pathway
Cell Communication
Regulation Of Immune Response
Regulation Of Immune System Process
Positive Regulation Of Immune Response
Positive Regulation Of Immune System Process
Innate Immune Response
Immune Response
Cellular Response To Stimulus
Blood Coagulation
Hemostasis
Cell Activation
Response To Stress
Defense Response
Positive Regulation Of Signal Transduction
Regulation Of Body Fluid Levels
Wound Healing
Regulation Of Signal Transduction
Response To Wounding
Positive Regulation Of Intracellular Signal Transduction
Response To External Stimulus
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Response To Stimulus
Fc Receptor Signaling Pathway
Regulation Of Signaling
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Protein Metabolic Process
Platelet Activation
Regulation Of Intracellular Signal Transduction
Antigen Receptor-mediated Signaling Pathway
Response To Organic Substance
Phosphorylation
Cellular Response To Organic Substance
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Metabolic Process
Peptidyl-tyrosine Autophosphorylation
Positive Regulation Of Cytokine Biosynthetic Process
Phosphate-containing Compound Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Leukocyte Activation
Protein Autophosphorylation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Enzyme Linked Receptor Protein Signaling Pathway
Response To Organic Substance
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
B Cell Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Cellular Response To Organic Substance
Regulation Of B Cell Cytokine Production
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Angiogenesis
Antigen Receptor-mediated Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Protein Kinase D Signaling
Cellular Response To Molecule Of Fungal Origin
Histone H3-T6 Phosphorylation
B Cell Activation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Cellular Response To Growth Factor Stimulus
Positive Regulation Of Histone Deacetylase Activity
Peptidyl-amino Acid Modification
Apoptotic Process
Cellular Response To Oxidative Stress
Programmed Cell Death
Protein Autophosphorylation
Response To Molecule Of Fungal Origin
Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway
Cell Death
Death
Regulation Of Angiogenesis
Regulation Of Signal Transduction
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway
Regulation Of Histone Deacetylase Activity
Phosphate-containing Compound Metabolic Process
Positive Regulation Of Deacetylase Activity
Regulation Of Signaling
Immune Response-activating Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Cellular Protein Modification Process
Protein Phosphorylation
Positive Regulation Of Endothelial Cell Chemotaxis
Positive Regulation Of B Cell Receptor Signaling Pathway
Cellular Response To Stimulus
Regulation Of Glycogen Catabolic Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Cell Death
Histamine Secretion By Mast Cell
Negative Regulation Of Transport
Tagcloud
?
adhesion
allergic
appear
asthma
compares
contrasts
csf
degranulation
describes
emerging
eosinophil
eosinophils
exert
gm
granulocyte
hematopoiesis
heterodimer
jak
lyn
macrophage
paramount
propagates
raf
segregation
seminal
shp
stat
syk
transduction
Tagcloud (Difference)
?
adhesion
allergic
appear
asthma
compares
contrasts
csf
degranulation
describes
emerging
eosinophil
eosinophils
exert
gm
granulocyte
hematopoiesis
heterodimer
jak
lyn
macrophage
paramount
propagates
raf
segregation
seminal
shp
stat
syk
transduction
Tagcloud (Intersection)
?