Wiki-Pi
About
Search
People
Updates
Search
BTK and PIK3R3
Number of citations of the paper that reports this interaction (PubMedID
25814554
)
62
Data Source:
BioGRID
(two hybrid)
BTK
PIK3R3
Description
Bruton tyrosine kinase
phosphoinositide-3-kinase regulatory subunit 3
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Cytoplasmic Vesicle
Membrane Raft
Perinuclear Region Of Cytoplasm
Cytosol
Phosphatidylinositol 3-kinase Complex
Phosphatidylinositol 3-kinase Complex, Class IA
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Phosphatidylinositol-3,4,5-trisphosphate Binding
Zinc Ion Binding
Lipid Binding
Phospholipase Activator Activity
Kinase Activity
Transferase Activity
Identical Protein Binding
Phospholipase Binding
Metal Ion Binding
Phosphotyrosine Residue Binding
Protein Binding
1-phosphatidylinositol-3-kinase Activity
1-phosphatidylinositol-3-kinase Regulator Activity
Biological Process
Neutrophil Homeostasis
Positive Regulation Of Type III Hypersensitivity
Positive Regulation Of Type I Hypersensitivity
Negative Regulation Of Cytokine Production
Adaptive Immune Response
B Cell Affinity Maturation
Immune System Process
Histamine Secretion By Mast Cell
Positive Regulation Of Immunoglobulin Production
Regulation Of B Cell Cytokine Production
MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of B Cell Apoptotic Process
Apoptotic Process
Mesoderm Development
Peptidyl-tyrosine Phosphorylation
Calcium-mediated Signaling
Proteoglycan Catabolic Process
Negative Regulation Of B Cell Proliferation
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Type I Interferon Production
Response To Lipopolysaccharide
Negative Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Cellular Response To Reactive Oxygen Species
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
B Cell Activation
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Positive Regulation Of B Cell Differentiation
Cell Maturation
Positive Regulation Of Phagocytosis
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Regulation Of B Cell Activation
Negative Regulation Of B Cell Activation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Monocyte Proliferation
Negative Regulation Of Leukocyte Proliferation
Cellular Response To Molecule Of Fungal Origin
Apoptotic Signaling Pathway
Cellular Response To Interleukin-7
CGAS/STING Signaling Pathway
Positive Regulation Of CGAS/STING Signaling Pathway
Positive Regulation Of Interleukin-17A Production
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Positive Regulation Of Synoviocyte Proliferation
Eosinophil Homeostasis
Cell Migration Involved In Sprouting Angiogenesis
Immune Response
Insulin Receptor Signaling Pathway
Positive Regulation Of Gene Expression
B Cell Differentiation
T Cell Differentiation
Positive Regulation Of Cell Migration
Phosphatidylinositol-3-phosphate Biosynthetic Process
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Anoikis
Pathways
ER-Phagosome pathway
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Regulation of actin dynamics for phagocytic cup formation
DAP12 signaling
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
G alpha (q) signalling events
G alpha (12/13) signalling events
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
RHO GTPases Activate WASPs and WAVEs
G beta:gamma signalling through BTK
FCGR3A-mediated phagocytosis
Potential therapeutics for SARS
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Synthesis of PIPs at the plasma membrane
Constitutive Signaling by Aberrant PI3K in Cancer
CD28 dependent PI3K/Akt signaling
G alpha (q) signalling events
Interleukin-3, Interleukin-5 and GM-CSF signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RET signaling
Extra-nuclear estrogen signaling
RAC1 GTPase cycle
RAC2 GTPase cycle
Interleukin receptor SHC signaling
Regulation of signaling by CBL
Regulation of signaling by CBL
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Co-stimulation by ICOS
Drugs
Dasatinib
Inositol 1,3,4,5-Tetrakisphosphate
XL418
Ibrutinib
Acalabrutinib
Spebrutinib
Fostamatinib
Fenebrutinib
Zanubrutinib
Evobrutinib
Tirabrutinib
Abivertinib
Branebrutinib
Vecabrutinib
SF1126
Diseases
Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS
Body mass index (
26426971
28448500
)
Body mass index (joint analysis main effects and physical activity interaction) (
28448500
)
Body mass index in physically active individuals (
28448500
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Breast cancer (
29059683
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (min-P) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Diastolic blood pressure (
30224653
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Estimated glomerular filtration rate (
31152163
)
Lymphocyte percentage of white cells (
32888494
)
Metabolite levels (
23823483
)
Neutrophil count (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Red cell distribution width (
32888494
)
Serum metabolite levels (
33031748
)
Sodium levels (
29403010
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Sum neutrophil eosinophil counts (
27863252
)
White blood cell count (
32888494
27863252
)
Interacting Genes
77 interacting genes:
ABL1
APP
AR
ARHGAP17
ARID3A
ARRB1
AURKA
BCL2L11
BECN1
BLNK
BMX
CAV1
CBL
CD19
CMTM3
COASY
CPVL
DAPP1
ERBB3
EWSR1
FAS
FASLG
FYN
GAB1
GNA12
GNAQ
GNG2
GTF2I
HCK
IBTK
IRAK1
ITK
JAK1
KHDRBS1
KIT
LYN
MDM2
MEOX2
MET
MRPS22
MYD88
PIK3AP1
PIK3R3
PIP4K2A
PIP4K2B
PIP4K2C
PIP5K1A
PIP5K1B
PIP5K1C
PLAU
PLCG1
PLCG2
PRKCA
PRKCB
PRKCE
PRKCQ
PRKCZ
PRKD1
RELA
RPS6KB1
RPS6KB2
SH2B2
SH3BP5
SMURF1
STAT5A
SYK
TEC
TIRAP
TLR4
TLR6
TLR8
TLR9
TNFRSF10A
TP53
VAV1
WAS
WASF2
122 interacting genes:
ABCB6
ABL2
AMBP
ANKS1A
ANTKMT
AR
ARID4B
AUNIP
AXL
BLK
BLZF1
BRK1
BTK
C3orf36
CAMK1
CCDC14
CCDC196
CCDC33
CCDC89
CEP126
CEP19
CHRDL2
CIMIP2B
CLNK
CRBN
CRK
DARS1
DCAF8
DISC1
DRAP1
DSN1
E2F6
EGFR
ENKD1
ERBB2
ERBB3
ERBB4
ESR1
FBN3
FER
FGB
FNDC8
FOXO1
FSD2
FYN
GAB1
GC
GRB2
HROB
HSH2D
IGF1R
INSR
IQUB
IRS1
IRS2
ITGB3BP
KARS1
KHDRBS1
KIAA0408
KIT
KLC2
KLF15
KMT2B
L3MBTL3
LAP3
LNX2
LUC7L2
MBIP
MECOM
MET
MICAL1
MTF2
NAB2
NCK1
NEBL
NEDD9
ORM1
PACRGL
PBX4
PCDHB5
PDGFRB
PELO
PIK3CA
PLAAT4
PLB1
PLEKHF2
PPARA
PRKAR1B
PSME1
PTK2
QARS1
RB1
RING1
RUSC1
SERF1A
SERTAD2
SPATA32
SPMIP6
SRC
SSBP4
STAT3
STAT5B
TASOR2
TEC
TERF2
TNK2
TNNC2
TNNI1
TRIM54
TRMT2A
TSPAN2
USP2
VBP1
VCP
WRNIP1
YES1
YPEL3
ZBTB18
ZMAT1
ZNF281
ZNF451
ZNF620
Entrez ID
695
8503
HPRD ID
02248
05831
Ensembl ID
ENSG00000010671
ENSG00000117461
Uniprot IDs
Q06187
Q5JY90
B4DXM8
Q8N381
Q92569
PDB IDs
1AWW
1AWX
1B55
1BTK
1BWN
1K2P
1QLY
2GE9
2Z0P
3GEN
3K54
3OCS
3OCT
3P08
3PIX
3PIY
3PIZ
3PJ1
3PJ2
3PJ3
4NWM
4OT5
4OT6
4OTF
4OTQ
4OTR
4RFY
4RFZ
4RG0
4RX5
4YHF
4Z3V
4ZLY
4ZLZ
5BPY
5BQ0
5FBN
5FBO
5J87
5JRS
5KUP
5P9F
5P9G
5P9H
5P9I
5P9J
5P9K
5P9L
5P9M
5T18
5U9D
5VFI
5VGO
5XYZ
5ZZ4
6AUA
6AUB
6BIK
6BKE
6BKH
6BKW
6BLN
6DI0
6DI1
6DI3
6DI5
6DI9
6E4F
6EP9
6HRP
6HRT
6HTF
6J6M
6N9P
6NFH
6NFI
6NZM
6O8I
6OMU
6S90
6TFP
6TSE
6TT2
6TUH
6TVN
6VXQ
6W06
6W07
6W7O
6W8I
6X3N
6X3O
6X3P
6XE4
6YYF
6YYG
6YYK
7KXL
7KXM
7KXN
7KXO
7KXP
7KXQ
7L5O
7L5P
7LTY
7LTZ
7N4Q
7N4R
7N4S
7N5O
7N5R
7N5X
7N5Y
7R60
7R61
7YC9
8DSO
8E2M
8EJB
8FLG
8FLH
8FLL
8FLN
8FLV
8GC7
8GC8
8TU3
8TU4
8TU5
8U2D
8U2E
8YVV
Enriched GO Terms of Interacting Partners
?
Immune Response-regulating Signaling Pathway
Signal Transduction
Immune Response-activating Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Activation Of Immune Response
Positive Regulation Of Immune Response
Cell Surface Receptor Signaling Pathway
Intracellular Signal Transduction
Positive Regulation Of Immune System Process
Regulation Of Immune Response
Kinase Activity
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Plasma Membrane
Positive Regulation Of Intracellular Signal Transduction
Immune System Process
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Immune System Process
Positive Regulation Of Signal Transduction
Innate Immune Response-activating Signaling Pathway
Activation Of Innate Immune Response
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Innate Immune Response
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Protein Kinase Activity
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
B Cell Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Fc Receptor Signaling Pathway
Intracellular Signaling Cassette
Leukocyte Activation
Cytoplasm
Antigen Receptor-mediated Signaling Pathway
Regulation Of Innate Immune Response
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Cellular Component Biogenesis
Cell Activation
Regulation Of Programmed Cell Death
Positive Regulation Of Defense Response
Positive Regulation Of Metabolic Process
Toll-like Receptor Signaling Pathway
Positive Regulation Of Gene Expression
Cell Surface Pattern Recognition Receptor Signaling Pathway
Response To Lipid
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Protein Tyrosine Kinase Activity
Enzyme-linked Receptor Protein Signaling Pathway
Peptidyl-tyrosine Phosphorylation
Non-membrane Spanning Protein Tyrosine Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Protein Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
ERBB Signaling Pathway
Kinase Activity
Phosphorylation
Negative Regulation Of Programmed Cell Death
Insulin Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Cellular Response To Hormone Stimulus
Protein Phosphorylation
Ephrin Receptor Binding
Positive Regulation Of Phosphate Metabolic Process
Ephrin Receptor Signaling Pathway
Phosphatidylinositol 3-kinase Binding
Insulin-like Growth Factor Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Fc Receptor Signaling Pathway
Protein Binding
Negative Regulation Of Apoptotic Process
Regulation Of MAPK Cascade
Cellular Response To Oxygen-containing Compound
Response To Peptide Hormone
SH2 Domain Binding
Positive Regulation Of Intracellular Signal Transduction
ERBB2 Signaling Pathway
Regulation Of Programmed Cell Death
ATP Binding
Positive Regulation Of Cell Population Proliferation
Cellular Response To Peptide Hormone Stimulus
Response To Platelet-derived Growth Factor
Regulation Of Phosphorus Metabolic Process
Cell Population Proliferation
Insulin Receptor Complex
Transferase Activity
Positive Regulation Of Cellular Component Organization
Receptor Complex
Signaling Adaptor Activity
Insulin Receptor Substrate Binding
Regulation Of Signal Transduction
Developmental Process
Immune Response-activating Cell Surface Receptor Signaling Pathway
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?