BTK and FAS

Number of citations of the paper that reports this interaction (PMID 9751072)
6

Data Source:
HPRD (in vivo)

		BTK	FAS
Gene Name		Bruton agammaglobulinemia tyrosine kinase	Fas cell surface death receptor
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle Mast Cell Granule Intracellular Membrane-bounded Organelle Membrane Raft Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Identical Protein Binding Metal Ion Binding	Signal Transducer Activity Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Kinase Binding Identical Protein Binding
	Biological Process	Toll-like Receptor Signaling Pathway Adaptive Immune Response Histamine Secretion By Mast Cell Regulation Of B Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of B Cell Apoptotic Process Transcription, DNA-templated Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Mesoderm Development Calcium-mediated Signaling Cell Differentiation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Response To Reactive Oxygen Species Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway B Cell Activation Regulation Of Cell Proliferation Innate Immune Response Positive Regulation Of B Cell Differentiation Cell Maturation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Molecule Of Fungal Origin Apoptotic Signaling Pathway	Immunoglobulin Production Renal System Process Protein Complex Assembly Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation-induced Cell Death Of T Cells Inflammatory Cell Apoptotic Process Transformed Cell Apoptotic Process Signal Transduction Circadian Rhythm Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Toxic Substance B Cell Mediated Immunity Positive Regulation Of Protein Homooligomerization Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Thymic T Cell Selection Regulation Of Lymphocyte Differentiation Regulation Of Myeloid Cell Differentiation Spleen Development Negative Regulation Of B Cell Activation Protein Homooligomerization Response To Glucocorticoid Cellular Response To Mechanical Stimulus Cellular Response To Lithium Ion Cellular Response To Hyperoxia Motor Neuron Apoptotic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Hepatocyte Apoptotic Process Necroptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Signaling by the B Cell Receptor (BCR) DAP12 interactions Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade DAP12 signaling Activated TLR4 signalling Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling MyD88:Mal cascade initiated on plasma membrane FCERI mediated Ca+2 mobilization Fcgamma receptor (FCGR) dependent phagocytosis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Regulation of actin dynamics for phagocytic cup formation Adaptive Immune System Innate Immune System	Death Receptor Signalling FasL/ CD95L signaling Programmed Cell Death Extrinsic Pathway
Drugs		Inositol 1,3,4,5-Tetrakisphosphate
Diseases
GWAS			Atrioventricular conduction ( 21041692) Immunoglobulin A ( 20694011) Obesity-related traits ( 23251661)
Protein-Protein Interactions		64 interactors: ABL1 APP ARHGAP17 ARID3A ARRB1 BCL2L11 BLNK BMX CAV1 CBL CD19 CMTM3 DAPP1 EWSR1 FAS FASLG FYN GNA12 GNAQ GNG2 GTF2I HCK IBTK IRAK1 ITK JAK1 KHDRBS1 KIT LYN MYD88 PIK3AP1 PIP4K2A PIP4K2B PIP4K2C PIP5K1A PIP5K1B PIP5K1C PLAU PLCG1 PLCG2 PRKCA PRKCB PRKCE PRKCQ PRKCZ PRKD1 RELA RPS6KB1 RPS6KB2 SH2B2 SH3BP5 STAT5A SYK TEC TIRAP TLR4 TLR6 TLR8 TLR9 TNFRSF10A TP53 VAV1 WAS WASF2	48 interactors: ANK3 APAF1 APOA5 ATP6V0B BAG6 BTK C14orf1 CALM1 CASP8 CASP8AP2 CCND3 CD47 CRMP1 DAXX EEF1A1 EGFR EZR FADD FAF1 FAF2 FAIM2 FASLG FBF1 FEM1B FYN GADD45A HIPK3 HNRNPC KRIT1 LCK LRIF1 MBD4 MET PDCD6 PRKCA PTPN13 PTPN6 RAP1A RIPK1 SUMO1 TCAP TMX1 TNFSF13 TRADD TRAF3 UBA7 UBE2I UBQLN1
Entrez ID		695	355
HPRD ID		02248	00609
Ensembl ID		ENSG00000010671	ENSG00000026103
Uniprot IDs		Q06187 Q5JY90	P25445
PDB IDs		1AWW 1AWX 1B55 1BTK 1BWN 1K2P 1QLY 2GE9 2Z0P 3GEN 3K54 3OCS 3OCT 3P08 3PIX 3PIY 3PIZ 3PJ1 3PJ2 3PJ3	1BZI 1DDF 3EWT 3EZQ 3THM 3TJE
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Signaling Pathway Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Immune System Process Signaling Cell Surface Receptor Signaling Pathway Cell Communication Regulation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Innate Immune Response Immune Response Cellular Response To Stimulus Blood Coagulation Hemostasis Cell Activation Response To Stress Defense Response Positive Regulation Of Signal Transduction Regulation Of Body Fluid Levels Wound Healing Regulation Of Signal Transduction Response To Wounding Positive Regulation Of Intracellular Signal Transduction Response To External Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Response To Stimulus Fc Receptor Signaling Pathway Regulation Of Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Platelet Activation Regulation Of Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway Response To Organic Substance Phosphorylation Cellular Response To Organic Substance Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Metabolic Process Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cytokine Biosynthetic Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Leukocyte Activation Protein Autophosphorylation	Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Catalytic Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Peptidase Activity Response To Stimulus Positive Regulation Of Catalytic Activity Regulation Of Signaling Regulation Of Metabolic Process Response To Stress Positive Regulation Of Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Proteolysis Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Protein Processing Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Signal Transduction Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Innate Immune Response Regulation Of Proteolysis Positive Regulation Of Macrophage Differentiation Response To Mechanical Stimulus Positive Regulation Of Hydrolase Activity Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell Communication Regulation Of Protein Kinase Activity Immune Response
Tagcloud ?		adhesion allergic appear asthma compares contrasts csf degranulation describes emerging eosinophil eosinophils exert gm granulocyte hematopoiesis heterodimer jak lyn macrophage paramount propagates raf segregation seminal shp stat syk transduction	activities auto catalytically constitute constitutive constitutively construct constructs deleted ds dsrna egfp fusion green inactive inducible jellyfish pkr possess possessed protected serine stranded substitution sufficient threonine transfection tumorigenic visualize
Tagcloud (Difference) ?		adhesion allergic appear asthma compares contrasts csf degranulation describes emerging eosinophil eosinophils exert gm granulocyte hematopoiesis heterodimer jak lyn macrophage paramount propagates raf segregation seminal shp stat syk transduction	activities auto catalytically constitute constitutive constitutively construct constructs deleted ds dsrna egfp fusion green inactive inducible jellyfish pkr possess possessed protected serine stranded substitution sufficient threonine transfection tumorigenic visualize
Tagcloud (Intersection) ?