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BTK and PRKCA
Number of citations of the paper that reports this interaction (PubMedID
7522330
)
35
Data Source:
HPRD
(in vitro, in vivo)
BTK
PRKCA
Description
Bruton tyrosine kinase
protein kinase C alpha
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Cytoplasmic Vesicle
Membrane Raft
Perinuclear Region Of Cytoplasm
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Membrane
Mitochondrial Membrane
Protein-containing Complex
Alphav-beta3 Integrin-PKCalpha Complex
Ciliary Basal Body
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Phosphatidylinositol-3,4,5-trisphosphate Binding
Zinc Ion Binding
Lipid Binding
Phospholipase Activator Activity
Kinase Activity
Transferase Activity
Identical Protein Binding
Phospholipase Binding
Metal Ion Binding
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Diacylglycerol-dependent Serine/threonine Kinase Activity
Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity
Signaling Receptor Binding
Integrin Binding
Protein Binding
ATP Binding
Zinc Ion Binding
Kinase Activity
Transferase Activity
Enzyme Binding
Diacylglycerol Binding
Histone H3T6 Kinase Activity
Metal Ion Binding
Protein Serine Kinase Activity
Biological Process
Neutrophil Homeostasis
Positive Regulation Of Type III Hypersensitivity
Positive Regulation Of Type I Hypersensitivity
Negative Regulation Of Cytokine Production
Adaptive Immune Response
B Cell Affinity Maturation
Immune System Process
Histamine Secretion By Mast Cell
Positive Regulation Of Immunoglobulin Production
Regulation Of B Cell Cytokine Production
MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of B Cell Apoptotic Process
Apoptotic Process
Mesoderm Development
Peptidyl-tyrosine Phosphorylation
Calcium-mediated Signaling
Proteoglycan Catabolic Process
Negative Regulation Of B Cell Proliferation
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Type I Interferon Production
Response To Lipopolysaccharide
Negative Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Cellular Response To Reactive Oxygen Species
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
B Cell Activation
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Positive Regulation Of B Cell Differentiation
Cell Maturation
Positive Regulation Of Phagocytosis
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Regulation Of B Cell Activation
Negative Regulation Of B Cell Activation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Monocyte Proliferation
Negative Regulation Of Leukocyte Proliferation
Cellular Response To Molecule Of Fungal Origin
Apoptotic Signaling Pathway
Cellular Response To Interleukin-7
CGAS/STING Signaling Pathway
Positive Regulation Of CGAS/STING Signaling Pathway
Positive Regulation Of Interleukin-17A Production
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Positive Regulation Of Synoviocyte Proliferation
Eosinophil Homeostasis
Response To Reactive Oxygen Species
Angiogenesis
Positive Regulation Of Endothelial Cell Proliferation
Desmosome Assembly
Chromatin Remodeling
Protein Phosphorylation
Apoptotic Process
Mitotic Nuclear Membrane Disassembly
Cell Adhesion
Learning Or Memory
Response To Mechanical Stimulus
Response To Toxic Substance
Positive Regulation Of Signal Transduction
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Cardiac Muscle Hypertrophy
Negative Regulation Of Translation
Central Nervous System Neuron Axonogenesis
Signal Transduction Involved In Regulation Of Gene Expression
Positive Regulation Of Cell Migration
Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Insulin Secretion
Response To Estradiol
Negative Regulation Of Glial Cell Apoptotic Process
Intracellular Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Response To Peptide Hormone
Regulation Of MRNA Stability
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Response To Ethanol
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Angiogenesis
Positive Regulation Of Bone Resorption
Positive Regulation Of Cell Adhesion
Positive Regulation Of Exocytosis
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Transport
Response To Corticosterone
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Synapse Assembly
Renal Sodium Ion Absorption
Positive Regulation Of ERK1 And ERK2 Cascade
Protein Kinase C Signaling
Response To Interleukin-1
Regulation Of Platelet Aggregation
Apoptotic Signaling Pathway
Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Angiotensin-activated Signaling Pathway
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Response To Phorbol 13-acetate 12-myristate
Positive Regulation Of Dense Core Granule Biogenesis
Pathways
ER-Phagosome pathway
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Regulation of actin dynamics for phagocytic cup formation
DAP12 signaling
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
G alpha (q) signalling events
G alpha (12/13) signalling events
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
RHO GTPases Activate WASPs and WAVEs
G beta:gamma signalling through BTK
FCGR3A-mediated phagocytosis
Potential therapeutics for SARS
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Calmodulin induced events
Disinhibition of SNARE formation
SHC1 events in ERBB2 signaling
Signaling by SCF-KIT
Regulation of KIT signaling
EGFR Transactivation by Gastrin
Inactivation, recovery and regulation of the phototransduction cascade
Syndecan interactions
Acetylcholine regulates insulin secretion
Ca2+ pathway
Trafficking of GluR2-containing AMPA receptors
G alpha (z) signalling events
Depolymerization of the Nuclear Lamina
HuR (ELAVL1) binds and stabilizes mRNA
WNT5A-dependent internalization of FZD4
VEGFR2 mediated cell proliferation
RHO GTPases Activate NADPH Oxidases
Response to elevated platelet cytosolic Ca2+
RET signaling
ROBO receptors bind AKAP5
ROBO receptors bind AKAP5
Drugs
Dasatinib
Inositol 1,3,4,5-Tetrakisphosphate
XL418
Ibrutinib
Acalabrutinib
Spebrutinib
Fostamatinib
Fenebrutinib
Zanubrutinib
Evobrutinib
Tirabrutinib
Abivertinib
Branebrutinib
Vecabrutinib
Phosphatidyl serine
Vitamin E
Tamoxifen
Staurosporine
Dequalinium
Ingenol mebutate
Aprinocarsen
Midostaurin
Perifosine
Ellagic acid
Benzoyl peroxide
Bryostatin 1
alpha-Tocopherol succinate
D-alpha-Tocopherol acetate
Diseases
Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS
Appendicular lean mass (
33097823
)
Bipolar disorder (
31043756
)
Body composition traits (
30026463
)
Brugada syndrome (
35210625
)
Cardiorespiratory fitness (800m run time) (
32572135
)
Carotid intima media thickness x smoking interaction (
32117412
)
Coronary artery calcification (
23870195
)
Cryptosporidiosis (
32019797
)
Daytime nap (
33568662
)
Dilated cardiomyopathy (MTAG) (
33495596
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Electrocardiographic traits (multivariate) (
32602732
)
Feeling guilty (
29500382
)
Food addiction (
27106561
)
Gout (
22179738
)
Haemorrhoidal disease (
33888516
)
Height (
22021425
)
Heschl's gyrus morphology (
25130324
)
Hypertrophic cardiomyopathy (
33495596
33495597
)
Hypertrophic cardiomyopathy (MTAG) (
33495596
)
Hypertrophic cardiomyopathy (sarcomere negative) (
33495597
)
Lateral occipital cortex volume (
31530798
)
Neuroticism (
29255261
)
Percent glycated albumin (
29844224
)
Possible neuropathic pain in post total joint replacement surgery for osteoarthritis (
28051079
)
Post-traumatic stress disorder (asjusted for relatedness) (
23726511
)
PR interval (
32439900
)
QRS complex (12-leadsum) (
27659466
)
QRS complex (Sokolow-Lyon) (
27659466
)
QRS duration (
30012220
27577874
27659466
)
QT interval (
24952745
29213071
29874175
)
Systolic blood pressure (
31170924
)
Total glycated albumin levels (
29844224
)
Interacting Genes
77 interacting genes:
ABL1
APP
AR
ARHGAP17
ARID3A
ARRB1
AURKA
BCL2L11
BECN1
BLNK
BMX
CAV1
CBL
CD19
CMTM3
COASY
CPVL
DAPP1
ERBB3
EWSR1
FAS
FASLG
FYN
GAB1
GNA12
GNAQ
GNG2
GTF2I
HCK
IBTK
IRAK1
ITK
JAK1
KHDRBS1
KIT
LYN
MDM2
MEOX2
MET
MRPS22
MYD88
PIK3AP1
PIK3R3
PIP4K2A
PIP4K2B
PIP4K2C
PIP5K1A
PIP5K1B
PIP5K1C
PLAU
PLCG1
PLCG2
PRKCA
PRKCB
PRKCE
PRKCQ
PRKCZ
PRKD1
RELA
RPS6KB1
RPS6KB2
SH2B2
SH3BP5
SMURF1
STAT5A
SYK
TEC
TIRAP
TLR4
TLR6
TLR8
TLR9
TNFRSF10A
TP53
VAV1
WAS
WASF2
230 interacting genes:
ACTA1
ADAP1
ADCY5
ADD1
ADD3
ADRA1B
AFAP1
AKAP12
AKAP5
ANXA2
ANXA7
APLP2
ARHGEF1
ATP1A1
ATP2B1
ATP2B2
AVPR1A
BCL2
BTG2
BTK
C1QBP
CACYBP
CASR
CAVIN2
CBL
CD163
CD5
CD9
CDC42
CDKN2A
CFTR
CHAT
CISH
CORO1B
CREM
CYP3A4
CYTH2
DDX5
DGKD
DGKZ
DLG4
DLX3
DNM1
DVL2
EDF1
EEF1D
EGFR
EGLN2
EIF2S1
EIF4E
EIF4EBP1
ELAVL1
ENTPD5
EP300
EWSR1
EZR
F11R
FAS
FBXO25
FBXO7
FCGR2B
FCGR3A
FLNA
FLNC
FSCN1
GABRB3
GABRG2
GABRR1
GABRR2
GFAP
GFPT1
GJA1
GJB1
GLI3
GMFB
GNA12
GNA15
GPM6A
GRIA1
GRIA2
GRIA4
GRIN1
GRIN2A
GRIN2B
GRK2
GRM1
GRM5
GSK3A
GSK3B
H1-1
H1-2
H1-3
H1-4
H1-5
H1-6
H3-4
H3C1
HABP4
HAND1
HAND2
HES1
HLA-A
HMGA1
HMGA2
HMGB1
HMGN1
HMGN2
HR
HSP90AA1
HSPA1A
HSPB8
IKBKB
INSR
ITGB1
ITGB2
ITGB4
ITPKA
ITPKB
KCNE1
KCNE4
KCNQ2
KIT
KLF5
KRT18
LCK
LMNA
LMNB1
MAPKAP1
MAPT
MARCKS
MBP
MGMT
MTOR
MYLK
MYOD1
NCF1
NF2
NFATC1
NFE2L2
NFKBIA
NHERF1
NHERF2
NOS1
NOXA1
NR1H2
NRGN
NUMB
OGG1
OPRD1
PA2G4
PAM
PDLIM7
PEA15
PEBP1
PFKFB1
PFKFB2
PHB2
PICK1
PLA2G4A
PLCB1
PLD1
PLD2
POLB
PPARA
PPARG
PPM1A
PPP1R14A
PRKCZ
PRKG1
PSMB4
PTGIR
PTPN1
PTPN11
PTPN12
PTPN6
RAC1
RACK1
RAF1
RALBP1
RARA
RBCK1
RGS19
RGS2
RGS7
RHO
RHOA
RNF31
RPL10
RRAD
SACM1L
SCRIB
SCTR
SDC2
SDC4
SELL
SEMG1
SEMG2
SHC1
SLC1A1
SLC6A9
SMURF1
SNAP23
SNAP25
SPAG1
SPP1
SRC
STMN1
STXBP1
STXBP3
SYK
TBXA2R
TEP1
TERT
THOC5
TIAM1
TNNI3
TNNT2
TNP1
TNP2
TOP2A
TP53
TRIM29
TRIM41
TRPC3
TRPV6
VCL
VTN
XK
YWHAG
YWHAZ
Entrez ID
695
5578
HPRD ID
02248
01498
Ensembl ID
ENSG00000010671
ENSG00000154229
Uniprot IDs
Q06187
Q5JY90
J3KRN5
L7RSM7
P17252
Q7Z727
PDB IDs
1AWW
1AWX
1B55
1BTK
1BWN
1K2P
1QLY
2GE9
2Z0P
3GEN
3K54
3OCS
3OCT
3P08
3PIX
3PIY
3PIZ
3PJ1
3PJ2
3PJ3
4NWM
4OT5
4OT6
4OTF
4OTQ
4OTR
4RFY
4RFZ
4RG0
4RX5
4YHF
4Z3V
4ZLY
4ZLZ
5BPY
5BQ0
5FBN
5FBO
5J87
5JRS
5KUP
5P9F
5P9G
5P9H
5P9I
5P9J
5P9K
5P9L
5P9M
5T18
5U9D
5VFI
5VGO
5XYZ
5ZZ4
6AUA
6AUB
6BIK
6BKE
6BKH
6BKW
6BLN
6DI0
6DI1
6DI3
6DI5
6DI9
6E4F
6EP9
6HRP
6HRT
6HTF
6J6M
6N9P
6NFH
6NFI
6NZM
6O8I
6OMU
6S90
6TFP
6TSE
6TT2
6TUH
6TVN
6VXQ
6W06
6W07
6W7O
6W8I
6X3N
6X3O
6X3P
6XE4
6YYF
6YYG
6YYK
7KXL
7KXM
7KXN
7KXO
7KXP
7KXQ
7L5O
7L5P
7LTY
7LTZ
7N4Q
7N4R
7N4S
7N5O
7N5R
7N5X
7N5Y
7R60
7R61
7YC9
8DSO
8E2M
8EJB
8FLG
8FLH
8FLL
8FLN
8FLV
8GC7
8GC8
8TU3
8TU4
8TU5
8U2D
8U2E
8YVV
2ELI
3IW4
4DNL
4RA4
8U37
8UAK
Enriched GO Terms of Interacting Partners
?
Immune Response-regulating Signaling Pathway
Signal Transduction
Immune Response-activating Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Activation Of Immune Response
Positive Regulation Of Immune Response
Cell Surface Receptor Signaling Pathway
Intracellular Signal Transduction
Positive Regulation Of Immune System Process
Regulation Of Immune Response
Kinase Activity
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Plasma Membrane
Positive Regulation Of Intracellular Signal Transduction
Immune System Process
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Immune System Process
Positive Regulation Of Signal Transduction
Innate Immune Response-activating Signaling Pathway
Activation Of Innate Immune Response
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Innate Immune Response
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Protein Kinase Activity
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
B Cell Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Fc Receptor Signaling Pathway
Intracellular Signaling Cassette
Leukocyte Activation
Cytoplasm
Antigen Receptor-mediated Signaling Pathway
Regulation Of Innate Immune Response
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Cellular Component Biogenesis
Cell Activation
Regulation Of Programmed Cell Death
Positive Regulation Of Defense Response
Positive Regulation Of Metabolic Process
Toll-like Receptor Signaling Pathway
Positive Regulation Of Gene Expression
Cell Surface Pattern Recognition Receptor Signaling Pathway
Response To Lipid
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Biological Quality
Regulation Of Transport
Regulation Of Signaling
Regulation Of Cell Communication
Plasma Membrane
Regulation Of Multicellular Organismal Process
Intracellular Signal Transduction
Positive Regulation Of Signaling
Signal Transduction
Positive Regulation Of Cell Communication
Regulation Of System Process
Regulation Of Developmental Process
Regulation Of Signal Transduction
Cellular Response To Oxygen-containing Compound
Positive Regulation Of Signal Transduction
Intracellular Signaling Cassette
Positive Regulation Of Transport
Regulation Of Cell Differentiation
Regulation Of Cellular Component Organization
Regulation Of Intracellular Signal Transduction
Developmental Process
Positive Regulation Of Multicellular Organismal Process
Negative Regulation Of Cell Communication
Regulation Of Cell Development
Regulation Of Membrane Potential
Cellular Developmental Process
Regulation Of Programmed Cell Death
Negative Regulation Of Signaling
Calmodulin Binding
Focal Adhesion
Regulation Of Apoptotic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Synaptic Plasticity
Regulation Of Blood Circulation
Cytosol
Negative Regulation Of Signal Transduction
Positive Regulation Of Developmental Process
Modulation Of Chemical Synaptic Transmission
Positive Regulation Of Metabolic Process
Regulation Of Protein Localization
Regulation Of Multicellular Organismal Development
Regulation Of Vesicle-mediated Transport
Protein Kinase Binding
Regulation Of Protein Metabolic Process
Cell Differentiation
Glutamatergic Synapse
Cytoplasm
Negative Regulation Of Programmed Cell Death
Regulation Of Metabolic Process
Dendritic Spine
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Tagcloud (Difference)
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Tagcloud (Intersection)
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