BTK and BCL2L11

Number of citations of the paper that reports this interaction (PMID 15096481)
7

Data Source:
BioGRID (pull down)

		BTK	BCL2L11
Gene Name		Bruton agammaglobulinemia tyrosine kinase	BCL2-like 11 (apoptosis facilitator)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle Mast Cell Granule Intracellular Membrane-bounded Organelle Membrane Raft Perinuclear Region Of Cytoplasm	Mitochondrial Outer Membrane Cytosol Microtubule Endomembrane System Extrinsic Component Of Membrane BIM-BCL-xl Complex BIM-BCL-2 Complex
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Identical Protein Binding Metal Ion Binding	Protein Binding Microtubule Binding
	Biological Process	Toll-like Receptor Signaling Pathway Adaptive Immune Response Histamine Secretion By Mast Cell Regulation Of B Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of B Cell Apoptotic Process Transcription, DNA-templated Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Mesoderm Development Calcium-mediated Signaling Cell Differentiation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Response To Reactive Oxygen Species Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway B Cell Activation Regulation Of Cell Proliferation Innate Immune Response Positive Regulation Of B Cell Differentiation Cell Maturation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Molecule Of Fungal Origin Apoptotic Signaling Pathway	In Utero Embryonic Development B Cell Homeostasis B Cell Apoptotic Process Kidney Development Myeloid Cell Homeostasis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell-matrix Adhesion Spermatogenesis Brain Development Male Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mammary Gland Development Positive Regulation Of Protein Homooligomerization Response To Endoplasmic Reticulum Stress Tube Formation Odontogenesis Of Dentin-containing Tooth T Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Ear Development Positive Regulation Of Cell Cycle Regulation Of Organ Growth Neurotrophin TRK Receptor Signaling Pathway Developmental Pigmentation Regulation Of Developmental Pigmentation Spleen Development Thymus Development Post-embryonic Organ Morphogenesis Positive Regulation Of Apoptotic Process By Virus Cellular Process Regulating Host Cell Cycle In Response To Virus Thymocyte Apoptotic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Apoptotic Process Involved In Embryonic Digit Morphogenesis Positive Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Signaling by the B Cell Receptor (BCR) DAP12 interactions Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade DAP12 signaling Activated TLR4 signalling Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling MyD88:Mal cascade initiated on plasma membrane FCERI mediated Ca+2 mobilization Fcgamma receptor (FCGR) dependent phagocytosis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Regulation of actin dynamics for phagocytic cup formation Adaptive Immune System Innate Immune System	Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Activation of BIM and translocation to mitochondria NRAGE signals death through JNK Programmed Cell Death Activation of BH3-only proteins p75 NTR receptor-mediated signalling BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Intrinsic Pathway for Apoptosis
Drugs		Inositol 1,3,4,5-Tetrakisphosphate
Diseases
GWAS			Chronic lymphocytic leukemia ( 18758461) Dehydroepiandrosterone sulphate levels ( 21533175) Primary sclerosing cholangitis ( 21151127)
Protein-Protein Interactions		64 interactors: ABL1 APP ARHGAP17 ARID3A ARRB1 BCL2L11 BLNK BMX CAV1 CBL CD19 CMTM3 DAPP1 EWSR1 FAS FASLG FYN GNA12 GNAQ GNG2 GTF2I HCK IBTK IRAK1 ITK JAK1 KHDRBS1 KIT LYN MYD88 PIK3AP1 PIP4K2A PIP4K2B PIP4K2C PIP5K1A PIP5K1B PIP5K1C PLAU PLCG1 PLCG2 PRKCA PRKCB PRKCE PRKCQ PRKCZ PRKD1 RELA RPS6KB1 RPS6KB2 SH2B2 SH3BP5 STAT5A SYK TEC TIRAP TLR4 TLR6 TLR8 TLR9 TNFRSF10A TP53 VAV1 WAS WASF2	26 interactors: AKT1 APP ATP6V1G1 AURKB BCL2 BCL2A1 BCL2L1 BCL2L2 BTK DYNLL1 DYNLL2 FEM1C FGL1 GNB2L1 GTF2I MAGEA11 MAPK10 MAPK8 MAPK9 MCL1 MEX3D RIOK3 SMARCB1 TRIM2 VDAC1 YWHAB
Entrez ID		695	10018
HPRD ID		02248	04828
Ensembl ID		ENSG00000010671	ENSG00000153094
Uniprot IDs		Q06187 Q5JY90	O43521
PDB IDs		1AWW 1AWX 1B55 1BTK 1BWN 1K2P 1QLY 2GE9 2Z0P 3GEN 3K54 3OCS 3OCT 3P08 3PIX 3PIY 3PIZ 3PJ1 3PJ2 3PJ3	1F95 2K7W 2NL9 2V6Q 2VM6 2WH6 2YQ6 3D7V 3FDL 3IO8 3IO9 3KJ0 3KJ1 3KJ2 4B4S
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Signaling Pathway Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Immune System Process Signaling Cell Surface Receptor Signaling Pathway Cell Communication Regulation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Innate Immune Response Immune Response Cellular Response To Stimulus Blood Coagulation Hemostasis Cell Activation Response To Stress Defense Response Positive Regulation Of Signal Transduction Regulation Of Body Fluid Levels Wound Healing Regulation Of Signal Transduction Response To Wounding Positive Regulation Of Intracellular Signal Transduction Response To External Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Response To Stimulus Fc Receptor Signaling Pathway Regulation Of Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Platelet Activation Regulation Of Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway Response To Organic Substance Phosphorylation Cellular Response To Organic Substance Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Metabolic Process Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cytokine Biosynthetic Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Leukocyte Activation Protein Autophosphorylation	Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway Programmed Cell Death Cell Death Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Mitochondrion Organization Positive Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Death Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand JUN Phosphorylation Intracellular Signal Transduction Apoptotic Mitochondrial Changes Regulation Of Signal Transduction Response To Radiation Positive Regulation Of Signal Transduction Response To Light Stimulus Regulation Of Signaling Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Extrinsic Apoptotic Signaling Pathway Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Cellular Response To Stress Positive Regulation Of Intracellular Transport Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Response To UV Regulation Of Establishment Of Protein Localization Fc Receptor Signaling Pathway Negative Regulation Of Cell Death Immune Response-regulating Signaling Pathway Regulation Of Neuron Death Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Defense Response Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Anoikis
Tagcloud ?		adhesion allergic appear asthma compares contrasts csf degranulation describes emerging eosinophil eosinophils exert gm granulocyte hematopoiesis heterodimer jak lyn macrophage paramount propagates raf segregation seminal shp stat syk transduction	akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask
Tagcloud (Difference) ?		adhesion allergic appear asthma compares contrasts csf degranulation describes emerging eosinophil eosinophils exert gm granulocyte hematopoiesis heterodimer jak lyn macrophage paramount propagates raf segregation seminal shp stat syk transduction	akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask
Tagcloud (Intersection) ?