TARBP1 and SREK1

Number of citations of the paper that reports this interaction (PubMedID 14559993)
73

Data Source:
BioGRID (two hybrid)

		TARBP1	SREK1
Description		tRNA guanosine 2 -O-methyltransferase TARBP1	splicing regulatory glutamic acid and lysine rich protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck
	Molecular Function	TRNA Binding RNA Binding Methyltransferase Activity RNA Methyltransferase Activity TRNA (guanine) Methyltransferase Activity Transferase Activity TRNA (guanine(18)-2'-O)-methyltransferase Activity	Nucleic Acid Binding RNA Binding Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II RNA Processing TRNA Processing TRNA Methylation Methylation	MRNA Processing RNA Splicing
Pathways
Drugs
Diseases
GWAS		Cognitive test performance ( 17903297) Psoriasis ( 25854761) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Systolic blood pressure ( 30224653)
Interacting Genes		3 interacting genes: ERG RNF10 SREK1	66 interacting genes: ARL6IP4 CD8A CKAP2 CSNK2A1 DDX17 DDX39B DDX3X DGKA DGKD EFTUD2 ELAVL1 GPRASP2 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPC HNRNPD HNRNPH1 HNRNPK HNRNPU ILF2 MDM2 MRPL37 NAT10 NCL NPM1 PABPC1 PABPC4 PARP1 PCBP3 PIN1 PRPF40A RAB5C RACK1 RBM10 RBM39 RBMX SAFB SF3A3 SF3B3 SFPQ SH3GLB2 SNRPD1 SNRPD3 SRPK1 SRPK2 SRPK3 SRRM4 SRSF1 SRSF10 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 SSRP1 SUPT16H TARBP1 THRAP3 TRA2B TXLNA YBX1 ZRANB2
Entrez ID		6894	140890
HPRD ID		05445	18043
Ensembl ID		ENSG00000059588	ENSG00000153914
Uniprot IDs		Q13395	Q8WXA9
PDB IDs		2HA8
Enriched GO Terms of Interacting Partners?		Mitochondrial Electron Transport, Succinate To Ubiquinone Respiratory Chain Complex II (succinate Dehydrogenase) Succinate Dehydrogenase (quinone) Activity 3 Iron, 4 Sulfur Cluster Binding Succinate Metabolic Process Ubiquinone Binding Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Disulfide Oxidoreductase Activity Insulin Processing Thiol Oxidase Activity	RNA Splicing RNA Binding MRNA Processing MRNA Metabolic Process RNA Processing Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process RNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Binding Regulation Of RNA Splicing RNA Splicing, Via Transesterification Reactions Nucleic Acid Metabolic Process MRNA Splicing, Via Spliceosome Nucleobase-containing Compound Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Binding Nuclear Speck Negative Regulation Of MRNA Metabolic Process Catalytic Step 2 Spliceosome Spliceosomal Complex Ribonucleoprotein Complex Nucleoplasm Nucleus Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of Primary Metabolic Process MRNA Stabilization Regulation Of Gene Expression Spliceosomal Complex Assembly Protein-RNA Complex Assembly Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Catabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Alternative MRNA Splicing, Via Spliceosome Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Pre-mRNA Binding Negative Regulation Of Macromolecule Biosynthetic Process
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