RNF111 and EDARADD

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		RNF111	EDARADD
Description		ring finger protein 111	EDAR associated via death domain
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body Protein-containing Complex	Cytoplasm Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity SUMO Polymer Binding SMAD Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Pattern Specification Process Protein Ubiquitination Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Global Genome Nucleotide-excision Repair	Signal Transduction Cell Differentiation
Pathways		Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Formation of Incision Complex in GG-NER Antigen processing: Ubiquitination & Proteasome degradation	TNFs bind their physiological receptors
Drugs
Diseases			Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic
GWAS		Apolipoprotein A1 levels ( 32203549) Asperger disorder ( 21182207) Atopic dermatitis ( 25865352) Cerebrospinal fluid AB1-42 levels ( 28247064) Metabolite levels ( 22916037) Social communication problems ( 24047820)	Autoimmune thyroid disease ( 32581359) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		57 interacting genes: ACTN3 ANAPC11 AP2M1 AXIN1 CREB1 CREBBP CTBP1 DTX3L EDARADD ERG ESR1 KRTAP1-1 KRTAP5-9 LCE4A LRSAM1 MARCHF7 MDFI MVP NBPF19 NOTCH2NLA PAX6 PHF7 PSME3 PTPN3 SDCBP2 SMAD3 SMAD6 SMAD7 SMURF2 SUMO1 SUMO2 SUMO3 TRAF5 TRIM21 TRIM8 TSG101 TSPYL1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2I UBE2K UBE2L3 UBE2M UBE2N UBE2Q2 UBE2V1 UBE2V2 UBE2W UBXN7 VAPB	11 interacting genes: EDAR LINC01554 NTAQ1 RNF111 SDCBP SHPRH SUMO1 SUMO1P1 TRAF2 TRAF6 UBE2I
Entrez ID		54778	128178
HPRD ID		09318	05965
Ensembl ID		ENSG00000157450	ENSG00000186197
Uniprot IDs		Q6ZNA4	A0A1B0GV26 Q8WWZ3
PDB IDs		2KIZ 5LG0 5LG7 7P2K
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification Process Protein K48-linked Ubiquitination Protein Metabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Binding Ubiquitin-dependent Protein Catabolic Process Cytosol Macromolecule Catabolic Process Protein Monoubiquitination Protein K11-linked Ubiquitination Macromolecule Metabolic Process Protein K63-linked Ubiquitination Proteolysis Nucleus Transferase Activity Positive Regulation Of Protein Polyubiquitination Nucleoplasm Ubiquitin Protein Ligase Activity UBC13-MMS2 Complex Regulation Of Protein Polyubiquitination Positive Regulation Of Protein Ubiquitination Enzyme Binding Negative Regulation Of BMP Signaling Pathway Dorsal/ventral Axis Specification Regulation Of Post-translational Protein Modification Protein Autoubiquitination Ubiquitin Conjugating Enzyme Complex Protein Tag Activity Regulation Of Protein Modification Process I-SMAD Binding Regulation Of Protein Metabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination Proteasomal Protein Catabolic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Catabolic Process Protein Catabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Primary Metabolic Process Ubiquitin-like Protein Ligase Binding	Protein Modification By Small Protein Conjugation Post-translational Protein Modification Transcription Factor Binding PML Body Protein Modification Process Regulation Of JNK Cascade Small Protein Activating Enzyme Binding Protein Sumoylation PML Body Organization Positive Regulation Of Canonical NF-kappaB Signal Transduction CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Protein Polyubiquitination CD40 Receptor Complex Positive Regulation Of JUN Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Canonical NF-kappaB Signal Transduction Protein Tag Activity Ubiquitin Protein Ligase Activity Nuclear Body Organization Protein Metabolic Process Enzyme Binding Ubiquitin-like Protein Ligase Binding Positive Regulation Of MAPK Cascade Positive Regulation Of T Cell Cytokine Production Presynaptic Cytosol Postsynaptic Cytosol Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Tumor Necrosis Factor Receptor Binding Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of MAP Kinase Activity Positive Regulation Of Interleukin-2 Production Regulation Of T Cell Cytokine Production Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Protein Ubiquitination Positive Regulation Of Phosphorylation Ubiquitin-protein Transferase Activity Interleukin-5 Receptor Complex Regulation Of MAPK Cascade TORC2 Complex Disassembly Positive Regulation Of Protein Serine/threonine Kinase Activity SUMO Conjugating Enzyme Activity Protein-N-terminal Glutamine Amidohydrolase Activity Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Interleukin-2 Production Regulation Of MAP Kinase Activity
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