RNF111 and PHF7

Number of citations of the paper that reports this interaction (PubMedID 22493164)
44

Data Source:
BioGRID (two hybrid)

		RNF111	PHF7
Description		ring finger protein 111	PHD finger protein 7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body Protein-containing Complex	Nucleus Nucleoplasm Golgi Apparatus Cytosol Plasma Membrane Nuclear Speck
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity SUMO Polymer Binding SMAD Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding
	Biological Process	Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Pattern Specification Process Protein Ubiquitination Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Global Genome Nucleotide-excision Repair	Negative Regulation Of Osteoclast Proliferation
Pathways		Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Formation of Incision Complex in GG-NER Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Asperger disorder ( 21182207) Atopic dermatitis ( 25865352) Cerebrospinal fluid AB1-42 levels ( 28247064) Metabolite levels ( 22916037) Social communication problems ( 24047820)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872) Triglyceride levels ( 32154731)
Interacting Genes		57 interacting genes: ACTN3 ANAPC11 AP2M1 AXIN1 CREB1 CREBBP CTBP1 DTX3L EDARADD ERG ESR1 KRTAP1-1 KRTAP5-9 LCE4A LRSAM1 MARCHF7 MDFI MVP NBPF19 NOTCH2NLA PAX6 PHF7 PSME3 PTPN3 SDCBP2 SMAD3 SMAD6 SMAD7 SMURF2 SUMO1 SUMO2 SUMO3 TRAF5 TRIM21 TRIM8 TSG101 TSPYL1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2I UBE2K UBE2L3 UBE2M UBE2N UBE2Q2 UBE2V1 UBE2V2 UBE2W UBXN7 VAPB	18 interacting genes: APP ARIH2 DTX3L FBXL17 H3-4 IKBKG MAGEF1 MDM2 RNF111 RNF14 RNF34 SRPK1 TRIM26 TRIM41 UBE2D2 UBE2D4 USP1 USP15
Entrez ID		54778	51533
HPRD ID		09318	15127
Ensembl ID		ENSG00000157450	ENSG00000010318
Uniprot IDs		Q6ZNA4	A0A024R336 A8K856 Q9BWX1
PDB IDs		2KIZ 5LG0 5LG7 7P2K
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification Process Protein K48-linked Ubiquitination Protein Metabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Binding Ubiquitin-dependent Protein Catabolic Process Cytosol Macromolecule Catabolic Process Protein Monoubiquitination Protein K11-linked Ubiquitination Macromolecule Metabolic Process Protein K63-linked Ubiquitination Proteolysis Nucleus Transferase Activity Positive Regulation Of Protein Polyubiquitination Nucleoplasm Ubiquitin Protein Ligase Activity UBC13-MMS2 Complex Regulation Of Protein Polyubiquitination Positive Regulation Of Protein Ubiquitination Enzyme Binding Negative Regulation Of BMP Signaling Pathway Dorsal/ventral Axis Specification Regulation Of Post-translational Protein Modification Protein Autoubiquitination Ubiquitin Conjugating Enzyme Complex Protein Tag Activity Regulation Of Protein Modification Process I-SMAD Binding Regulation Of Protein Metabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination Proteasomal Protein Catabolic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Catabolic Process Protein Catabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Primary Metabolic Process Ubiquitin-like Protein Ligase Binding	Post-translational Protein Modification Protein Ubiquitination Protein Polyubiquitination Protein Modification Process Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Activity Protein Metabolic Process Macromolecule Catabolic Process Nucleus Protein K48-linked Ubiquitination Macromolecule Metabolic Process Ubiquitin-protein Transferase Activity Transferase Activity Catabolic Process Nucleoplasm Innate Immune Response Defense Response To Symbiont Defense Response To Other Organism Regulation Of Cellular Response To Stress Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Monoubiquitinated Protein Deubiquitination Response To Virus Regulation Of Signal Transduction Protein Autoubiquitination Zinc Ion Binding Response To Stress Response To Other Organism Protein-containing Complex Proteasomal Protein Catabolic Process Immune Response Regulation Of Cell Communication Regulation Of Signaling Defense Response To Virus Ubiquitin Ligase Complex Response To External Biotic Stimulus Intracellular Signal Transduction Regulation Of Signal Transduction By P53 Class Mediator Defense Response Immune System Process Protein K6-linked Ubiquitination Protein Catabolic Process Amyloid Fibril Formation Cytosol Ubiquitin Conjugating Enzyme Binding
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