RNF111 and LRSAM1

Number of citations of the paper that reports this interaction (PubMedID 22493164)
44

Data Source:
BioGRID (two hybrid)

		RNF111	LRSAM1
Description		ring finger protein 111	leucine rich repeat and sterile alpha motif containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body Protein-containing Complex	Cytoplasm Cytosol Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity SUMO Polymer Binding SMAD Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Pattern Specification Process Protein Ubiquitination Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Global Genome Nucleotide-excision Repair	Protein Polyubiquitination Autophagy Protein Transport Protein Ubiquitination Protein Catabolic Process Negative Regulation Of Endocytosis Viral Budding Protein Autoubiquitination Ubiquitin-dependent Endocytosis Positive Regulation Of Xenophagy Positive Regulation Of Autophagosome Assembly
Pathways		Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Formation of Incision Complex in GG-NER Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Asperger disorder ( 21182207) Atopic dermatitis ( 25865352) Cerebrospinal fluid AB1-42 levels ( 28247064) Metabolite levels ( 22916037) Social communication problems ( 24047820)	Mean corpuscular volume ( 32888494)
Interacting Genes		57 interacting genes: ACTN3 ANAPC11 AP2M1 AXIN1 CREB1 CREBBP CTBP1 DTX3L EDARADD ERG ESR1 KRTAP1-1 KRTAP5-9 LCE4A LRSAM1 MARCHF7 MDFI MVP NBPF19 NOTCH2NLA PAX6 PHF7 PSME3 PTPN3 SDCBP2 SMAD3 SMAD6 SMAD7 SMURF2 SUMO1 SUMO2 SUMO3 TRAF5 TRIM21 TRIM8 TSG101 TSPYL1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2I UBE2K UBE2L3 UBE2M UBE2N UBE2Q2 UBE2V1 UBE2V2 UBE2W UBXN7 VAPB	46 interacting genes: ATXN1 ATXN7 CCDC6 DMAP1 FAM178B FXR1 GABARAPL2 GPR108 GRIK5 GSK3A HUNK KLC1 MAGEA1 MDM4 MGAT4B MKRN3 MUTYH MYL2 NINL PHF23 RNF111 RXRG TERF1 TNFRSF10C TRIM17 TRIM74 TSC1 TSG101 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2H UBE2I UBE2J1 UBE2K UBE2N UBE2W UEVLD USP2 USP21 VPS11 XAF1 ZMAT4
Entrez ID		54778	90678
HPRD ID		09318	14325
Ensembl ID		ENSG00000157450	ENSG00000148356
Uniprot IDs		Q6ZNA4	A0A6Q8PGW1 Q6UWE0
PDB IDs		2KIZ 5LG0 5LG7 7P2K
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification Process Protein K48-linked Ubiquitination Protein Metabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Binding Ubiquitin-dependent Protein Catabolic Process Cytosol Macromolecule Catabolic Process Protein Monoubiquitination Protein K11-linked Ubiquitination Macromolecule Metabolic Process Protein K63-linked Ubiquitination Proteolysis Nucleus Transferase Activity Positive Regulation Of Protein Polyubiquitination Nucleoplasm Ubiquitin Protein Ligase Activity UBC13-MMS2 Complex Regulation Of Protein Polyubiquitination Positive Regulation Of Protein Ubiquitination Enzyme Binding Negative Regulation Of BMP Signaling Pathway Dorsal/ventral Axis Specification Regulation Of Post-translational Protein Modification Protein Autoubiquitination Ubiquitin Conjugating Enzyme Complex Protein Tag Activity Regulation Of Protein Modification Process I-SMAD Binding Regulation Of Protein Metabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination Proteasomal Protein Catabolic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Catabolic Process Protein Catabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Primary Metabolic Process Ubiquitin-like Protein Ligase Binding	Ubiquitin Conjugating Enzyme Activity Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Polyubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Proteolysis Protein Modification Process Macromolecule Catabolic Process Protein K48-linked Ubiquitination Catabolic Process Protein Metabolic Process Transferase Activity Ubiquitin Protein Ligase Binding Protein K11-linked Ubiquitination Negative Regulation Of TOR Signaling Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Ubiquitination Protein Monoubiquitination Macromolecule Metabolic Process TORC1 Signaling Positive Regulation Of Post-translational Protein Modification Negative Regulation Of TORC1 Signaling Nucleus Regulation Of TOR Signaling ATP Binding TOR Signaling Positive Regulation Of Protein Targeting To Mitochondrion Nucleotide Binding Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Regulation Of TORC1 Signaling Regulation Of Protein Ubiquitination Regulation Of Protein Targeting To Mitochondrion Proteasomal Protein Catabolic Process ESCRT I Complex Endosome To Lysosome Transport Regulation Of Establishment Of Protein Localization Negative Regulation Of Catabolic Process Cytosol Positive Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Excitatory Postsynaptic Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Nutrient Levels Regulation Of Macromolecule Metabolic Process
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