RNF111 and UBE2K

Number of citations of the paper that reports this interaction (PMID 19549727)
40

Data Source:
BioGRID (two hybrid)

		RNF111	UBE2K
Gene Name		ring finger protein 111	ubiquitin-conjugating enzyme E2K
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Protein Complex	Nucleus Cytoplasm Actin Cytoskeleton Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Ligase Activity SUMO Polymer Binding SMAD Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Pattern Specification Process Gene Expression Protein Ubiquitination Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter	Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein K48-linked Ubiquitination
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer Antigen processing: Ubiquitination & Proteasome degradation SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Loss of Function of TGFBR1 in Cancer Generic Transcription Pathway Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Class I MHC mediated antigen processing & presentation SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Antigen processing: Ubiquitination & Proteasome degradation Negative regulators of RIG-I/MDA5 signaling Class I MHC mediated antigen processing & presentation Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS		Asperger disorder ( 21182207) Metabolite levels ( 22916037)
Protein-Protein Interactions		39 interactors: ACTN3 ANAPC11 AXIN1 CREB1 CSNK2A1 CTBP1 DTX3L EDARADD KRTAP5-9 LCE4A LRSAM1 MARCH7 MVP PHF7 PML SMAD3 SMAD6 SMAD7 SMURF2 SUMO2 TRAF5 TRIM21 TRIM8 TSG101 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2I UBE2K UBE2M UBE2Q2 UBE2V1 UBE2W	68 interactors: AMFR ANAPC11 BFAR BIRC7 BIRC8 BRCA1 CASP12 CBLC CDC6 DDI1 DDX58 DIABLO DTX3 DTX3L DZIP3 FZR1 HTT ITCH ITSN1 LRSAM1 MARCH3 MARCH7 MDM2 MID1 MIPOL1 MKRN2 MKRN3 NEDD4L NEDD8 NFKB1 NUB1 PIAS4 PRPF40A PRRG4 RBCK1 REL RING1 RNF111 RNF114 RNF125 RNF138 RNF144A RNF167 RNF2 RNF32 RNF4 RNF41 RNF5 SIAH1 TP53 TRAF7 TRAIP TRIM2 TRIM27 TRIM3 TRIM31 TRIM34 TRIM35 TRIM39 TRIM43 TRIM5 UBA1 UBC UBE2I UBOX5 UHRF2 WWP2 ZDHHC17
Entrez ID		54778	3093
HPRD ID		09318	04165
Ensembl ID		ENSG00000157450	ENSG00000078140
Uniprot IDs		Q6ZNA4	B4DIZ2 P61086
PDB IDs		2KIZ	1YLA 2O25 3E46 3F92 3K9O 3K9P
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Polyubiquitination Cellular Protein Modification Process Protein K48-linked Ubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Protein K11-linked Ubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Macromolecule Catabolic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Proteolysis Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Gene Expression Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Chromosome Organization Protein Monoubiquitination Negative Regulation Of Biosynthetic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Ubiquitination Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Metabolic Process Toll-like Receptor Signaling Pathway Regulation Of Protein Ubiquitination Negative Regulation Of Protein Catabolic Process Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition TRIF-dependent Toll-like Receptor Signaling Pathway	Protein Modification By Small Protein Conjugation Protein Ubiquitination Cellular Protein Modification Process Protein Polyubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Proteolysis Proteasomal Protein Catabolic Process Apoptotic Process Programmed Cell Death Cell Death Death Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cell Death Protein K63-linked Ubiquitination Negative Regulation Of Cellular Metabolic Process Metabolic Process Regulation Of Apoptotic Process Catabolic Process Protein Autoubiquitination Positive Regulation Of Signal Transduction Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of RNA Biosynthetic Process Viral Process Neuron Apoptotic Process Response To Stress Negative Regulation Of Biosynthetic Process Regulation Of Viral Release From Host Cell Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Process Neuron Death Regulation Of Signaling Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle
Tagcloud ?			antiviral attributes breadth chains conjugase cooperated demands e3 elicits elusive epsilon hundreds identifies ifn ikkepsilon interacted interferons isg isgs k48 ligase polyubiquitin stat1 trim trim6 tripartite ubiquitin unanchored unrecognized
Tagcloud (Difference) ?			antiviral attributes breadth chains conjugase cooperated demands e3 elicits elusive epsilon hundreds identifies ifn ikkepsilon interacted interferons isg isgs k48 ligase polyubiquitin stat1 trim trim6 tripartite ubiquitin unanchored unrecognized
Tagcloud (Intersection) ?