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RNF111 and TRAF5
Number of citations of the paper that reports this interaction (PMID
22493164
)
2
Data Source:
BioGRID
(two hybrid)
RNF111
TRAF5
Gene Name
ring finger protein 111
TNF receptor-associated factor 5
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Protein Complex
Cytoplasm
Centrosome
Cytosol
Cytoplasmic Side Of Plasma Membrane
CD40 Receptor Complex
Molecular Function
Protein Binding
Zinc Ion Binding
Ligase Activity
SUMO Polymer Binding
SMAD Binding
Ubiquitin Protein Ligase Activity
Ubiquitin-protein Transferase Activity
Signal Transducer Activity
Protein Binding
Zinc Ion Binding
Ubiquitin Protein Ligase Binding
Thioesterase Binding
Biological Process
Protein Polyubiquitination
Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Transforming Growth Factor Beta Receptor Signaling Pathway
Pattern Specification Process
Gene Expression
Protein Ubiquitination
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Ubiquitin-dependent SMAD Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Apoptotic Process
Signal Transduction
Positive Regulation Of Cell Proliferation
Protein Ubiquitination
Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways
Loss of Function of TGFBR2 in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
Antigen processing: Ubiquitination & Proteasome degradation
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
Downregulation of SMAD2/3:SMAD4 transcriptional activity
TGFBR1 LBD Mutants in Cancer
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Loss of Function of TGFBR1 in Cancer
Generic Transcription Pathway
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
Class I MHC mediated antigen processing & presentation
SMAD4 MH2 Domain Mutants in Cancer
Adaptive Immune System
Drugs
Diseases
GWAS
Asperger disorder (
21182207
)
Metabolite levels (
22916037
)
Protein-Protein Interactions
39 interactors:
ACTN3
ANAPC11
AXIN1
CREB1
CSNK2A1
CTBP1
DTX3L
EDARADD
KRTAP5-9
LCE4A
LRSAM1
MARCH7
MVP
PHF7
PML
SMAD3
SMAD6
SMAD7
SMURF2
SUMO2
TRAF5
TRIM21
TRIM8
TSG101
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G2
UBE2I
UBE2K
UBE2M
UBE2Q2
UBE2V1
UBE2W
42 interactors:
CAPNS1
CCDC184
CD27
CD40
COG7
COMMD3
DGKH
ENOX2
GORASP2
LTBR
MAP3K14
MAP3K5
MAVS
MDM2
NGFRAP1
NMI
NUMBL
RAD23A
RIPK1
RIPK2
RNF111
SDCBP
SEC13
SERPINB9
TDP2
THAP1
TNFRSF11A
TNFRSF12A
TNFRSF13B
TNFRSF14
TNFRSF19
TNFRSF4
TNFRSF8
TRAF2
TRAF3
TRAF3IP2
TRAF6
TRIM27
TRIM37
TRIM8
USP7
ZFAND6
Entrez ID
54778
7188
HPRD ID
09318
03834
Ensembl ID
ENSG00000157450
ENSG00000082512
Uniprot IDs
Q6ZNA4
D3DT93
O00463
PDB IDs
2KIZ
Enriched GO Terms of Interacting Partners
?
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Protein Polyubiquitination
Cellular Protein Modification Process
Protein K48-linked Ubiquitination
Cellular Protein Metabolic Process
Protein Metabolic Process
Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Protein K11-linked Ubiquitination
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Regulation Of Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Cellular Metabolic Process
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Cellular Macromolecule Catabolic Process
Negative Regulation Of Protein Metabolic Process
Positive Regulation Of Proteolysis
Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Toll-like Receptor 4 Signaling Pathway
Regulation Of Proteolysis
Positive Regulation Of Cellular Protein Catabolic Process
Negative Regulation Of Gene Expression
Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of Chromosome Organization
Protein Monoubiquitination
Negative Regulation Of Biosynthetic Process
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Protein Ubiquitination
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Cellular Metabolic Process
Toll-like Receptor Signaling Pathway
Regulation Of Protein Ubiquitination
Negative Regulation Of Protein Catabolic Process
Catabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
TRIF-dependent Toll-like Receptor Signaling Pathway
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Programmed Cell Death
Cell Death
Death
Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of JNK Cascade
Cellular Response To Stimulus
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Immune System Process
Regulation Of Protein Metabolic Process
Cellular Response To Tumor Necrosis Factor
Positive Regulation Of Signal Transduction
Regulation Of JNK Cascade
Immune Response
Signal Transduction
Apoptotic Process
Regulation Of Stress-activated MAPK Cascade
Response To Tumor Necrosis Factor
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Cellular Protein Metabolic Process
Signaling
Positive Regulation Of MAPK Cascade
Cell Communication
Cellular Response To Organic Substance
Regulation Of Apoptotic Process
Response To Stimulus
Positive Regulation Of Phosphorylation
Regulation Of Intracellular Signal Transduction
Regulation Of Cytokine Production
Response To Cytokine
Regulation Of Phosphorylation
Regulation Of Cell Death
Cellular Response To Cytokine Stimulus
Positive Regulation Of MAP Kinase Activity
Cytokine-mediated Signaling Pathway
Cell Surface Receptor Signaling Pathway
Regulation Of MAPK Cascade
Response To Organic Substance
Regulation Of Immunoglobulin Secretion
Positive Regulation Of Protein Metabolic Process
Regulation Of Phosphorus Metabolic Process
Regulation Of Immune System Process
Regulation Of Lymphocyte Activation
Defense Response
Positive Regulation Of Protein Serine/threonine Kinase Activity
Tagcloud
?
adhesion
affinity
bind
cd40
cd40ct
cytoplasmic
dispensable
dominantly
extensive
icam
ikappabalpha
implicated
incapable
intercellular
jak3
kappab
mediators
molecule
much
mutants
necrosis
residues
strongly
tail
traf2
traf3
traf6
transduction
Tagcloud (Difference)
?
adhesion
affinity
bind
cd40
cd40ct
cytoplasmic
dispensable
dominantly
extensive
icam
ikappabalpha
implicated
incapable
intercellular
jak3
kappab
mediators
molecule
much
mutants
necrosis
residues
strongly
tail
traf2
traf3
traf6
transduction
Tagcloud (Intersection)
?