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RNF111 and UBE2D4
Number of citations of the paper that reports this interaction (PMID
19549727
)
40
Data Source:
BioGRID
(two hybrid, two hybrid)
RNF111
UBE2D4
Gene Name
ring finger protein 111
ubiquitin-conjugating enzyme E2D 4 (putative)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Protein Complex
Molecular Function
Protein Binding
Zinc Ion Binding
Ligase Activity
SUMO Polymer Binding
SMAD Binding
Ubiquitin Protein Ligase Activity
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ligase Activity
Ubiquitin Conjugating Enzyme Activity
Biological Process
Protein Polyubiquitination
Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Transforming Growth Factor Beta Receptor Signaling Pathway
Pattern Specification Process
Gene Expression
Protein Ubiquitination
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Ubiquitin-dependent SMAD Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Protein Ubiquitination
Protein K29-linked Ubiquitination
Protein K27-linked Ubiquitination
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Protein K6-linked Ubiquitination
Pathways
Loss of Function of TGFBR2 in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
Antigen processing: Ubiquitination & Proteasome degradation
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
Downregulation of SMAD2/3:SMAD4 transcriptional activity
TGFBR1 LBD Mutants in Cancer
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Loss of Function of TGFBR1 in Cancer
Generic Transcription Pathway
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
Class I MHC mediated antigen processing & presentation
SMAD4 MH2 Domain Mutants in Cancer
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Drugs
Diseases
GWAS
Asperger disorder (
21182207
)
Metabolite levels (
22916037
)
Protein-Protein Interactions
39 interactors:
ACTN3
ANAPC11
AXIN1
CREB1
CSNK2A1
CTBP1
DTX3L
EDARADD
KRTAP5-9
LCE4A
LRSAM1
MARCH7
MVP
PHF7
PML
SMAD3
SMAD6
SMAD7
SMURF2
SUMO2
TRAF5
TRIM21
TRIM8
TSG101
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G2
UBE2I
UBE2K
UBE2M
UBE2Q2
UBE2V1
UBE2W
90 interactors:
AMFR
ARIH2
BFAR
BIRC8
CADPS2
CHFR
CNOT4
DAZAP2
DTX1
DTX2
DTX3
DTX3L
DZIP3
INCA1
LRSAM1
MAGEA11
MAP3K1
MARCH3
MGRN1
MIB1
MID1
MID2
MKRN2
MKRN3
MUL1
MYBL2
MYLIP
OTUB1
PHF7
PJA2
RBCK1
RCHY1
RFWD3
RING1
RLIM
RMND5B
RNF10
RNF103
RNF11
RNF111
RNF114
RNF115
RNF125
RNF126
RNF13
RNF130
RNF138
RNF14
RNF150
RNF165
RNF166
RNF167
RNF181
RNF185
RNF2
RNF25
RNF26
RNF38
RNF4
RNF43
RNF5
RNF7
SIAH1
TOPORS
TRAF6
TRAF7
TRIM10
TRIM17
TRIM2
TRIM25
TRIM27
TRIM3
TRIM31
TRIM35
TRIM38
TRIM39
TRIM43
TRIM45
TRIM5
TRIM50
TRIM8
UBE4A
UBOX5
UBTD1
UFM1
UHRF2
XIAP
ZNRF1
ZNRF2
ZNRF4
Entrez ID
54778
51619
HPRD ID
09318
14242
Ensembl ID
ENSG00000157450
ENSG00000078967
Uniprot IDs
Q6ZNA4
Q9Y2X8
PDB IDs
2KIZ
Enriched GO Terms of Interacting Partners
?
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Protein Polyubiquitination
Cellular Protein Modification Process
Protein K48-linked Ubiquitination
Cellular Protein Metabolic Process
Protein Metabolic Process
Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Protein K11-linked Ubiquitination
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Regulation Of Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Cellular Metabolic Process
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Cellular Macromolecule Catabolic Process
Negative Regulation Of Protein Metabolic Process
Positive Regulation Of Proteolysis
Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Toll-like Receptor 4 Signaling Pathway
Regulation Of Proteolysis
Positive Regulation Of Cellular Protein Catabolic Process
Negative Regulation Of Gene Expression
Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of Chromosome Organization
Protein Monoubiquitination
Negative Regulation Of Biosynthetic Process
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Protein Ubiquitination
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Cellular Metabolic Process
Toll-like Receptor Signaling Pathway
Regulation Of Protein Ubiquitination
Negative Regulation Of Protein Catabolic Process
Catabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
TRIF-dependent Toll-like Receptor Signaling Pathway
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Cellular Protein Modification Process
Cellular Protein Metabolic Process
Protein Metabolic Process
Protein Polyubiquitination
Protein Autoubiquitination
Cellular Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Protein K63-linked Ubiquitination
Regulation Of Viral Entry Into Host Cell
Protein K48-linked Ubiquitination
Regulation Of Viral Release From Host Cell
Negative Regulation Of Viral Release From Host Cell
Negative Regulation Of Viral Entry Into Host Cell
Metabolic Process
Negative Regulation Of Viral Process
Catabolic Process
Proteolysis
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Viral Process
Protein Monoubiquitination
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Signal Transduction
Negative Regulation Of Viral Transcription
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Cellular Process
Regulation Of Signal Transduction
Innate Immune Response
Interferon-gamma-mediated Signaling Pathway
Regulation Of Protein Ubiquitination
Cellular Response To Interferon-gamma
Regulation Of Signaling
Positive Regulation Of Intracellular Signal Transduction
Apoptotic Process
Response To Interferon-gamma
Programmed Cell Death
Cell Death
Death
Histone Monoubiquitination
Tagcloud
?
accumulation
apoptosis
apoptotic
arsenic
cadmium
conjugating
degradation
downregulation
elevated
enzymes
family
hand
induce
inorganic
mercury
p53
promote
proteasomal
proximal
rat
suppressed
suppression
tubular
ubiquitin
ubiquitination
Tagcloud (Difference)
?
accumulation
apoptosis
apoptotic
arsenic
cadmium
conjugating
degradation
downregulation
elevated
enzymes
family
hand
induce
inorganic
mercury
p53
promote
proteasomal
proximal
rat
suppressed
suppression
tubular
ubiquitin
ubiquitination
Tagcloud (Intersection)
?