SRPK1 and CHEK2

Number of citations of the paper that reports this interaction (PMID 23602568)
8

Data Source:
BioGRID (enzymatic study)

		SRPK1	CHEK2
Gene Name		SRSF protein kinase 1	checkpoint kinase 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Plasma Membrane Nuclear Matrix	Chromosome, Telomeric Region Nucleoplasm Golgi Apparatus PML Body
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Poly(A) RNA Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	MRNA Processing Protein Phosphorylation Chromosome Segregation RNA Splicing Viral Process Sperm Chromatin Condensation Intracellular Signal Transduction Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Innate Immune Response Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing	DNA Damage Checkpoint G2/M Transition Of Mitotic Cell Cycle Double-strand Break Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Gamma Radiation Regulation Of Protein Catabolic Process Signal Transduction In Response To DNA Damage Cellular Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Protein Stabilization Cell Division Signal Transduction Involved In Intra-S DNA Damage Checkpoint Mitotic Spindle Assembly Replicative Senescence
Pathways
Drugs
Diseases
GWAS			Breast cancer ( 23535729) Breast size ( 22747683) Esophageal cancer (squamous cell) ( 22960999) Esophageal cancer and gastric cancer ( 20729852) Vertical cup-disc ratio ( 20548946)
Protein-Protein Interactions		174 interactors: ADPRH AHCYL1 ALKBH3 AMMECR1L APEX1 APP ARGLU1 ARHGAP12 ARHGAP26 ARL6IP4 ASAH1 ASXL1 AURKA AURKC C11orf52 C11orf63 C11orf87 C16orf78 C18orf25 C9orf72 CACNB1 CAMK2D CBX5 CDC42EP3 CDK7 CDKL3 CHEK2 CHERP CHUK CIAO1 CLIC5 CLK1 CLK4 CRHR1 CSAG1 DAW1 DDX47 DGCR8 DHX8 DHX9 DNAJC8 DUSP6 ECM1 EIF3M EPB41L4A EPHA3 ERBB2 ESRRG FAM124A FAM76B FERMT1 FGF12 FHL1 FKBP3 FLOT1 FLT1 GABARAP GABARAPL1 H2AFY HBS1L HIRIP3 HMGN3 HNRNPA1 IFIT5 IKBKG KCNAB1 KCNN2 KIAA1841 KPNA2 KPTN KRR1 LAMC1 LARP1 LBR LCE3D LIMK1 LINC00312 LUC7L LUC7L2 LUC7L3 MAGEB1 MAOB MAP1LC3A MAPK12 MAPK14 MAPKAPK5 MBNL3 MBP MRPL43 MRPS11 NCK2 NELFE NKAP NOL4L NOP16 NOVA1 NSMCE4A NSRP1 NUDT21 NXT2 OCEL1 ODF3L2 OR6B3 PAK4 PDGFRA PDPK1 PELI1 PELI2 PEX19 PFN1 PHF7 POLR2E PPIA PPIL1 PRM1 PRPF38A PTK2 RBM23 RBM39 RBM8A RBMS2 RIMS4 RNPS1 RPS6KB2 RSRC1 RSRC2 RSRP1 SAFB SCAF11 SEC23B SERPINB10 SETD3 SFMBT1 SLAIN2 SLC4A1AP SNRNP70 SPANXN4 SPATS2 SREK1 SRPK3 SRRM1 SRSF1 SRSF12 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 STAU1 STK26 SUDS3 TAF1B TFEB TNFRSF10C TOP2A TRA2B TRIM65 U2AF1 U2AF2 UBD UBE2E2 USP39 VANGL1 VDR WDR55 YPEL2 YTHDC1 YWHAG ZMYND11 ZNF444 ZNF514 ZRANB2 ZRSR2	47 interactors: AATF APP ARHGAP1 ASF1A ATM ATR BRCA1 BRCA2 CDC25A CDC25C DAPK3 DBF4 E2F1 ELAVL1 ERCC6 FOXM1 KPNA2 LATS2 MDC1 MDM2 MDM4 MRC1 MSH2 MUS81 NBN NR4A1 PLK1 PLK3 POLR2L PPP2CA PPP2R2A PPP2R2B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKDC RAD9A RCHY1 REV3L RNF8 SRPK1 STRAP TP53 TSSK1B VHL
Entrez ID		6732	11200
HPRD ID		15992	05084
Ensembl ID		ENSG00000096063	ENSG00000183765
Uniprot IDs		B4DS61 Q96SB4	O96017
PDB IDs		1WAK 1WBP 3BEG	1GXC 2CN5 2CN8 2W0J 2W7X 2WTC 2WTD 2WTI 2WTJ 2XBJ 2XK9 2XM8 2XM9 2YCF 2YCQ 2YCR 2YCS 2YIQ 2YIR 2YIT 3I6U 3I6W 3VA4 4A9R 4A9S 4A9T 4A9U 4BDA 4BDB 4BDC 4BDD 4BDE 4BDF 4BDG 4BDH 4BDI 4BDJ 4BDK
Enriched GO Terms of Interacting Partners?		MRNA Processing RNA Processing RNA Splicing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Gene Expression RNA Metabolic Process DNA-templated Transcription, Termination Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Termination Of RNA Polymerase II Transcription Heterocycle Metabolic Process Cellular Metabolic Process MRNA 3'-end Processing Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Splicing Nitrogen Compound Metabolic Process RNA 3'-end Processing Spliceosomal Complex Assembly RNA Export From Nucleus Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Export From Nucleus RNA Localization Nuclear Export MRNA Transport RNA Transport Nucleocytoplasmic Transport Nuclear Transport MRNA Splice Site Selection Ribonucleoprotein Complex Biogenesis Cellular Process Ribonucleoprotein Complex Assembly Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of Gene Expression Protein Autophosphorylation Cytoplasmic Transport Regulation Of Alternative MRNA Splicing, Via Spliceosome Posttranscriptional Regulation Of Gene Expression Cellular Component Assembly Transcription, DNA-templated Metabolic Process Cellular Macromolecular Complex Assembly Regulation Of Metabolic Process RNA Biosynthetic Process Protein Phosphorylation Positive Regulation Of Viral Process Regulation Of Nitrogen Compound Metabolic Process	Cellular Response To DNA Damage Stimulus Cell Cycle Process Cellular Response To Stress Cell Cycle Regulation Of Cell Cycle Mitotic Cell Cycle Process DNA Damage Checkpoint Regulation Of Mitotic Cell Cycle Cellular Response To Stimulus Mitotic Cell Cycle DNA Metabolic Process Cell Cycle Checkpoint Response To Stress Signal Transduction By P53 Class Mediator DNA Repair Regulation Of Cell Cycle Process Signal Transduction In Response To DNA Damage Regulation Of Metabolic Process Response To Stimulus Mitotic Cell Cycle Checkpoint DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Radiation Negative Regulation Of Cell Cycle Apoptotic Process Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Programmed Cell Death Mitotic DNA Damage Checkpoint Regulation Of Protein Metabolic Process Double-strand Break Repair Mitotic DNA Integrity Checkpoint Cell Death Death Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cellular Metabolic Process Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Intracellular Signal Transduction Response To Abiotic Stimulus Signal Transduction DNA Recombination Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Signaling Nucleobase-containing Compound Metabolic Process Cell Communication Double-strand Break Repair Via Homologous Recombination Recombinational Repair
Tagcloud ?		70k arginine asf clk cloning coexpressed contributing dipeptides nh2 pancreas phosphorylate preference preferred proline redistribution reversible rs sf2 similarities spliceosome splicing srpk2 stringent sty u1 uniquely ww	alleles atm brca1 brca2 brip1 cdh1 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue
Tagcloud (Difference) ?		70k arginine asf clk cloning coexpressed dipeptides nh2 pancreas phosphorylate preference preferred proline redistribution reversible rs sf2 similarities spliceosome splicing srpk2 stringent sty u1 uniquely ww	alleles atm brca1 brca2 brip1 cdh1 confer contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue
Tagcloud (Intersection) ?		contributing