SRPK1 and ASXL1

Number of citations of the paper that reports this interaction (PMID 23602568)
8

Data Source:
BioGRID (enzymatic study)

		SRPK1	ASXL1
Gene Name		SRSF protein kinase 1	additional sex combs like transcriptional regulator 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Plasma Membrane Nuclear Matrix	Nuclear Chromatin PR-DUB Complex Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Poly(A) RNA Binding	DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Metal Ion Binding
	Biological Process	MRNA Processing Protein Phosphorylation Chromosome Segregation RNA Splicing Viral Process Sperm Chromatin Condensation Intracellular Signal Transduction Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Innate Immune Response Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Response To Retinoic Acid Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Monoubiquitinated Histone H2A Deubiquitination Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Bone Development
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		174 interactors: ADPRH AHCYL1 ALKBH3 AMMECR1L APEX1 APP ARGLU1 ARHGAP12 ARHGAP26 ARL6IP4 ASAH1 ASXL1 AURKA AURKC C11orf52 C11orf63 C11orf87 C16orf78 C18orf25 C9orf72 CACNB1 CAMK2D CBX5 CDC42EP3 CDK7 CDKL3 CHEK2 CHERP CHUK CIAO1 CLIC5 CLK1 CLK4 CRHR1 CSAG1 DAW1 DDX47 DGCR8 DHX8 DHX9 DNAJC8 DUSP6 ECM1 EIF3M EPB41L4A EPHA3 ERBB2 ESRRG FAM124A FAM76B FERMT1 FGF12 FHL1 FKBP3 FLOT1 FLT1 GABARAP GABARAPL1 H2AFY HBS1L HIRIP3 HMGN3 HNRNPA1 IFIT5 IKBKG KCNAB1 KCNN2 KIAA1841 KPNA2 KPTN KRR1 LAMC1 LARP1 LBR LCE3D LIMK1 LINC00312 LUC7L LUC7L2 LUC7L3 MAGEB1 MAOB MAP1LC3A MAPK12 MAPK14 MAPKAPK5 MBNL3 MBP MRPL43 MRPS11 NCK2 NELFE NKAP NOL4L NOP16 NOVA1 NSMCE4A NSRP1 NUDT21 NXT2 OCEL1 ODF3L2 OR6B3 PAK4 PDGFRA PDPK1 PELI1 PELI2 PEX19 PFN1 PHF7 POLR2E PPIA PPIL1 PRM1 PRPF38A PTK2 RBM23 RBM39 RBM8A RBMS2 RIMS4 RNPS1 RPS6KB2 RSRC1 RSRC2 RSRP1 SAFB SCAF11 SEC23B SERPINB10 SETD3 SFMBT1 SLAIN2 SLC4A1AP SNRNP70 SPANXN4 SPATS2 SREK1 SRPK3 SRRM1 SRSF1 SRSF12 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 STAU1 STK26 SUDS3 TAF1B TFEB TNFRSF10C TOP2A TRA2B TRIM65 U2AF1 U2AF2 UBD UBE2E2 USP39 VANGL1 VDR WDR55 YPEL2 YTHDC1 YWHAG ZMYND11 ZNF444 ZNF514 ZRANB2 ZRSR2	4 interactors: APP HIST1H1C SRPK1 STAT3
Entrez ID		6732	171023
HPRD ID		15992	16516
Ensembl ID		ENSG00000096063	ENSG00000171456
Uniprot IDs		B4DS61 Q96SB4	Q498B9 Q8IXJ9
PDB IDs		1WAK 1WBP 3BEG
Enriched GO Terms of Interacting Partners?		MRNA Processing RNA Processing RNA Splicing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Gene Expression RNA Metabolic Process DNA-templated Transcription, Termination Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Termination Of RNA Polymerase II Transcription Heterocycle Metabolic Process Cellular Metabolic Process MRNA 3'-end Processing Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Splicing Nitrogen Compound Metabolic Process RNA 3'-end Processing Spliceosomal Complex Assembly RNA Export From Nucleus Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Export From Nucleus RNA Localization Nuclear Export MRNA Transport RNA Transport Nucleocytoplasmic Transport Nuclear Transport MRNA Splice Site Selection Ribonucleoprotein Complex Biogenesis Cellular Process Ribonucleoprotein Complex Assembly Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of Gene Expression Protein Autophosphorylation Cytoplasmic Transport Regulation Of Alternative MRNA Splicing, Via Spliceosome Posttranscriptional Regulation Of Gene Expression Cellular Component Assembly Transcription, DNA-templated Metabolic Process Cellular Macromolecular Complex Assembly Regulation Of Metabolic Process RNA Biosynthetic Process Protein Phosphorylation Positive Regulation Of Viral Process Regulation Of Nitrogen Compound Metabolic Process	Feeding Behavior Regulation Of Multicellular Organism Growth Sexual Reproduction Synaptic Growth At Neuromuscular Junction Reproduction DNA Packaging Intracellular Receptor Signaling Pathway Collateral Sprouting In Absence Of Injury Reproductive Process Defense Response Collateral Sprouting Axon Midline Choice Point Recognition DNA Conformation Change Regulation Of Developmental Growth Negative Regulation Of Neurogenesis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Nucleosome Positioning Axon Choice Point Recognition Negative Regulation Of Cell Development Negative Regulation Of Glycolytic Process Neuron Remodeling Sperm Chromatin Condensation Radial Glial Cell Differentiation Cell Development Phosphorylation MRNA Processing Interleukin-6-mediated Signaling Pathway MRNA Metabolic Process Cellular Copper Ion Homeostasis Viral Process RNA Processing JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Viral Genome Replication Behavior Copper Ion Homeostasis Suckling Behavior Regulation Of Growth Growth Hormone Receptor Signaling Pathway Temperature Homeostasis Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cellular Response To Growth Hormone Stimulus Cellular Response To Interleukin-6 Regulation Of Glycolytic Process Positive Regulation Of Notch Signaling Pathway Eating Behavior Spermatid Nucleus Differentiation Neuron Maturation Negative Regulation Of Neuron Migration MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity
Tagcloud ?		70k arginine asf clk cloning coexpressed contributing dipeptides nh2 pancreas phosphorylate preference preferred proline redistribution reversible rs sf2 similarities spliceosome splicing srpk2 stringent sty u1 uniquely ww	abstract advancements ascribed attitude azacitidine challenging changing choices conditioning curative decitabine feasible haploidentical hematologists hypomethylating idh2 incurable optimize overview profoundly renders sf3b1 sibling spite stratify tet2 transplant video wider
Tagcloud (Difference) ?		70k arginine asf clk cloning coexpressed contributing dipeptides nh2 pancreas phosphorylate preference preferred proline redistribution reversible rs sf2 similarities spliceosome splicing srpk2 stringent sty u1 uniquely ww	abstract advancements ascribed attitude azacitidine challenging changing choices conditioning curative decitabine feasible haploidentical hematologists hypomethylating idh2 incurable optimize overview profoundly renders sf3b1 sibling spite stratify tet2 transplant video wider
Tagcloud (Intersection) ?