SRPK1 and SRSF6

Number of citations of the paper that reports this interaction (PMID 8208298)
141

Data Source:
HPRD (in vivo, in vitro)

		SRPK1	SRSF6
Gene Name		SRSF protein kinase 1	serine/arginine-rich splicing factor 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Plasma Membrane Nuclear Matrix	Nucleoplasm Nuclear Speck
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Poly(A) RNA Binding	Nucleotide Binding RNA Binding Pre-mRNA Binding Poly(A) RNA Binding
	Biological Process	MRNA Processing Protein Phosphorylation Chromosome Segregation RNA Splicing Viral Process Sperm Chromatin Condensation Intracellular Signal Transduction Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Innate Immune Response Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing	Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Splice Site Selection MRNA Export From Nucleus RNA Splicing Gene Expression Regulation Of Keratinocyte Proliferation MRNA 3'-end Processing Negative Regulation Of Keratinocyte Differentiation Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Negative Regulation Of Cell Death Regulation Of Wound Healing
Pathways			mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing
Drugs
Diseases
GWAS
Protein-Protein Interactions		174 interactors: ADPRH AHCYL1 ALKBH3 AMMECR1L APEX1 APP ARGLU1 ARHGAP12 ARHGAP26 ARL6IP4 ASAH1 ASXL1 AURKA AURKC C11orf52 C11orf63 C11orf87 C16orf78 C18orf25 C9orf72 CACNB1 CAMK2D CBX5 CDC42EP3 CDK7 CDKL3 CHEK2 CHERP CHUK CIAO1 CLIC5 CLK1 CLK4 CRHR1 CSAG1 DAW1 DDX47 DGCR8 DHX8 DHX9 DNAJC8 DUSP6 ECM1 EIF3M EPB41L4A EPHA3 ERBB2 ESRRG FAM124A FAM76B FERMT1 FGF12 FHL1 FKBP3 FLOT1 FLT1 GABARAP GABARAPL1 H2AFY HBS1L HIRIP3 HMGN3 HNRNPA1 IFIT5 IKBKG KCNAB1 KCNN2 KIAA1841 KPNA2 KPTN KRR1 LAMC1 LARP1 LBR LCE3D LIMK1 LINC00312 LUC7L LUC7L2 LUC7L3 MAGEB1 MAOB MAP1LC3A MAPK12 MAPK14 MAPKAPK5 MBNL3 MBP MRPL43 MRPS11 NCK2 NELFE NKAP NOL4L NOP16 NOVA1 NSMCE4A NSRP1 NUDT21 NXT2 OCEL1 ODF3L2 OR6B3 PAK4 PDGFRA PDPK1 PELI1 PELI2 PEX19 PFN1 PHF7 POLR2E PPIA PPIL1 PRM1 PRPF38A PTK2 RBM23 RBM39 RBM8A RBMS2 RIMS4 RNPS1 RPS6KB2 RSRC1 RSRC2 RSRP1 SAFB SCAF11 SEC23B SERPINB10 SETD3 SFMBT1 SLAIN2 SLC4A1AP SNRNP70 SPANXN4 SPATS2 SREK1 SRPK3 SRRM1 SRSF1 SRSF12 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 STAU1 STK26 SUDS3 TAF1B TFEB TNFRSF10C TOP2A TRA2B TRIM65 U2AF1 U2AF2 UBD UBE2E2 USP39 VANGL1 VDR WDR55 YPEL2 YTHDC1 YWHAG ZMYND11 ZNF444 ZNF514 ZRANB2 ZRSR2	14 interactors: APP CLK1 LUC7L2 PPARGC1A RBM10 RNPS1 SF3B4 SREK1 SRPK1 SRSF4 TERF1 TERF2 TOE1 TRA2B
Entrez ID		6732	6431
HPRD ID		15992	09054
Ensembl ID		ENSG00000096063	ENSG00000124193
Uniprot IDs		B4DS61 Q96SB4	Q13247
PDB IDs		1WAK 1WBP 3BEG
Enriched GO Terms of Interacting Partners?		MRNA Processing RNA Processing RNA Splicing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Gene Expression RNA Metabolic Process DNA-templated Transcription, Termination Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Termination Of RNA Polymerase II Transcription Heterocycle Metabolic Process Cellular Metabolic Process MRNA 3'-end Processing Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Splicing Nitrogen Compound Metabolic Process RNA 3'-end Processing Spliceosomal Complex Assembly RNA Export From Nucleus Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Export From Nucleus RNA Localization Nuclear Export MRNA Transport RNA Transport Nucleocytoplasmic Transport Nuclear Transport MRNA Splice Site Selection Ribonucleoprotein Complex Biogenesis Cellular Process Ribonucleoprotein Complex Assembly Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of Gene Expression Protein Autophosphorylation Cytoplasmic Transport Regulation Of Alternative MRNA Splicing, Via Spliceosome Posttranscriptional Regulation Of Gene Expression Cellular Component Assembly Transcription, DNA-templated Metabolic Process Cellular Macromolecular Complex Assembly Regulation Of Metabolic Process RNA Biosynthetic Process Protein Phosphorylation Positive Regulation Of Viral Process Regulation Of Nitrogen Compound Metabolic Process	MRNA Processing MRNA Metabolic Process RNA Processing RNA Splicing Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nitrogen Compound Metabolic Process Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication RNA Metabolic Process Telomeric Loop Formation Age-dependent Telomere Shortening Gene Expression Telomere Maintenance Via Telomere Shortening Replicative Cell Aging MRNA 3'-end Processing Regulation Of Nuclear Cell Cycle DNA Replication Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process RNA 3'-end Processing Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Telomere Maintenance Negative Regulation Of RNA Splicing RNA-dependent DNA Replication Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome Telomere Maintenance Via Telomere Lengthening Positive Regulation Of RNA Splicing Regulation Of Chromosome Organization Termination Of RNA Polymerase II Transcription Negative Regulation Of DNA Replication Negative Regulation Of Cellular Metabolic Process Cellular Response To Nitrite MRNA Export From Nucleus DNA-templated Transcription, Termination Cell Aging RNA Export From Nucleus Regulation Of RNA Metabolic Process Telomere Maintenance Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Chromosome Organization
Tagcloud ?		70k arginine asf clk cloning coexpressed contributing dipeptides nh2 pancreas phosphorylate preference preferred proline redistribution reversible rs sf2 similarities spliceosome splicing srpk2 stringent sty u1 uniquely ww	a1 a1b a2 anchorage b1 constitutive dominant egf elevating erk erk1 hcc hepatocellular hnrnp immortalized isoform knockdown mapk mek oncogenes overexpressing progenitor raf ras regulates splicing srsf1 switch transcript
Tagcloud (Difference) ?		70k arginine asf clk cloning coexpressed contributing dipeptides nh2 pancreas phosphorylate preference preferred proline redistribution reversible rs sf2 similarities spliceosome srpk2 stringent sty u1 uniquely ww	a1 a1b a2 anchorage b1 constitutive dominant egf elevating erk erk1 hcc hepatocellular hnrnp immortalized isoform knockdown mapk mek oncogenes overexpressing progenitor raf ras regulates srsf1 switch transcript
Tagcloud (Intersection) ?		splicing