SRPK1 and MAOB

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SRPK1	MAOB
Gene Name		SRSF protein kinase 1	monoamine oxidase B
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Plasma Membrane Nuclear Matrix	Mitochondrion Mitochondrial Envelope Mitochondrial Outer Membrane Mitochondrial Inner Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Poly(A) RNA Binding	Primary Amine Oxidase Activity Electron Carrier Activity Protein Homodimerization Activity Flavin Adenine Dinucleotide Binding
	Biological Process	MRNA Processing Protein Phosphorylation Chromosome Segregation RNA Splicing Viral Process Sperm Chromatin Condensation Intracellular Signal Transduction Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Innate Immune Response Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing	Xenobiotic Metabolic Process Response To Toxic Substance Response To Aluminum Ion Response To Selenium Ion Negative Regulation Of Serotonin Secretion Substantia Nigra Development Response To Lipopolysaccharide Dopamine Catabolic Process Response To Drug Small Molecule Metabolic Process Response To Ethanol Positive Regulation Of Dopamine Metabolic Process Hydrogen Peroxide Biosynthetic Process Response To Corticosterone Oxidation-reduction Process
Pathways			Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolic disorders of biological oxidation enzymes Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Phase 1 - Functionalization of compounds Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Biological oxidations Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB Amine Oxidase reactions Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs			Phentermine Tranylcypromine Phenelzine Zonisamide Selegiline Isocarboxazid Ephedra Rasagiline MMDA 4-Methoxyamphetamine Methamphetamine Pargyline Isatin N-Methyl-N-Propargyl-1(R)-Aminoindan Farnesol N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-Propanesulfonate [(1e)-4-Phenylbut-1-Enyl]Benzene Flavin-Adenine Dinucleotide N-Propargyl-1(S)-Aminoindan Lauryl Dimethylamine-N-Oxide 5-Hydroxy-N-Propargyl-1(R)-Aminoindan N-METHYL-N-[(1R)-1-METHYL-2-PHENYLETHYL]PROP-2-EN-1-AMINE Nialamide Nomifensine Zimelidine 7-[(3-CHLOROBENZYL)OXY]-2-OXO-2H-CHROMENE-4-CARBALDEHYDE 7-[(3-CHLOROBENZYL)OXY]-4-[(METHYLAMINO)METHYL]-2H-CHROMEN-2-ONE N-(2-AMINOETHYL)-P-CHLOROBENZAMIDE (1Z)-4-(4-FLUOROPHENYL)-2-METHYLIDENEBUTAN-1-IMINE 4-HYDROXY-N-PROPARGYL-1(R)-AMINOINDAN (S)-(+)-2-[4-(FLUOROBENZYLOXY-BENZYLAMINO)PROPIONAMIDE]
Diseases
GWAS
Protein-Protein Interactions		174 interactors: ADPRH AHCYL1 ALKBH3 AMMECR1L APEX1 APP ARGLU1 ARHGAP12 ARHGAP26 ARL6IP4 ASAH1 ASXL1 AURKA AURKC C11orf52 C11orf63 C11orf87 C16orf78 C18orf25 C9orf72 CACNB1 CAMK2D CBX5 CDC42EP3 CDK7 CDKL3 CHEK2 CHERP CHUK CIAO1 CLIC5 CLK1 CLK4 CRHR1 CSAG1 DAW1 DDX47 DGCR8 DHX8 DHX9 DNAJC8 DUSP6 ECM1 EIF3M EPB41L4A EPHA3 ERBB2 ESRRG FAM124A FAM76B FERMT1 FGF12 FHL1 FKBP3 FLOT1 FLT1 GABARAP GABARAPL1 H2AFY HBS1L HIRIP3 HMGN3 HNRNPA1 IFIT5 IKBKG KCNAB1 KCNN2 KIAA1841 KPNA2 KPTN KRR1 LAMC1 LARP1 LBR LCE3D LIMK1 LINC00312 LUC7L LUC7L2 LUC7L3 MAGEB1 MAOB MAP1LC3A MAPK12 MAPK14 MAPKAPK5 MBNL3 MBP MRPL43 MRPS11 NCK2 NELFE NKAP NOL4L NOP16 NOVA1 NSMCE4A NSRP1 NUDT21 NXT2 OCEL1 ODF3L2 OR6B3 PAK4 PDGFRA PDPK1 PELI1 PELI2 PEX19 PFN1 PHF7 POLR2E PPIA PPIL1 PRM1 PRPF38A PTK2 RBM23 RBM39 RBM8A RBMS2 RIMS4 RNPS1 RPS6KB2 RSRC1 RSRC2 RSRP1 SAFB SCAF11 SEC23B SERPINB10 SETD3 SFMBT1 SLAIN2 SLC4A1AP SNRNP70 SPANXN4 SPATS2 SREK1 SRPK3 SRRM1 SRSF1 SRSF12 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 STAU1 STK26 SUDS3 TAF1B TFEB TNFRSF10C TOP2A TRA2B TRIM65 U2AF1 U2AF2 UBD UBE2E2 USP39 VANGL1 VDR WDR55 YPEL2 YTHDC1 YWHAG ZMYND11 ZNF444 ZNF514 ZRANB2 ZRSR2	2 interactors: NFYB SRPK1
Entrez ID		6732	4129
HPRD ID		15992	02401
Ensembl ID		ENSG00000096063	ENSG00000069535
Uniprot IDs		B4DS61 Q96SB4	B7Z242 B7Z5H3 P27338
PDB IDs		1WAK 1WBP 3BEG	1GOS 1H8R 1OJ9 1OJA 1OJC 1OJD 1S2Q 1S2Y 1S3B 1S3E 2BK3 2BK4 2BK5 2BYB 2C64 2C65 2C66 2C67 2C70 2C72 2C73 2C75 2C76 2V5Z 2V60 2V61 2VRL 2VRM 2VZ2 2XCG 2XFN 2XFO 2XFP 2XFQ 2XFU 3PO7 3ZYX 4A79 4A7A
Enriched GO Terms of Interacting Partners?		MRNA Processing RNA Processing RNA Splicing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Gene Expression RNA Metabolic Process DNA-templated Transcription, Termination Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Termination Of RNA Polymerase II Transcription Heterocycle Metabolic Process Cellular Metabolic Process MRNA 3'-end Processing Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Splicing Nitrogen Compound Metabolic Process RNA 3'-end Processing Spliceosomal Complex Assembly RNA Export From Nucleus Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Export From Nucleus RNA Localization Nuclear Export MRNA Transport RNA Transport Nucleocytoplasmic Transport Nuclear Transport MRNA Splice Site Selection Ribonucleoprotein Complex Biogenesis Cellular Process Ribonucleoprotein Complex Assembly Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of Gene Expression Protein Autophosphorylation Cytoplasmic Transport Regulation Of Alternative MRNA Splicing, Via Spliceosome Posttranscriptional Regulation Of Gene Expression Cellular Component Assembly Transcription, DNA-templated Metabolic Process Cellular Macromolecular Complex Assembly Regulation Of Metabolic Process RNA Biosynthetic Process Protein Phosphorylation Positive Regulation Of Viral Process Regulation Of Nitrogen Compound Metabolic Process
Tagcloud ?		70k arginine asf clk cloning coexpressed contributing dipeptides nh2 pancreas phosphorylate preference preferred proline redistribution reversible rs sf2 similarities spliceosome splicing srpk2 stringent sty u1 uniquely ww	black c57 competitive concentrated depleting dopamine dopaminergic exerts inactivates intraneuronally irreversible irreversibly keeping kinetics label mazindol moiety mptp neurotoxin pargyline phenyl pretreatment protected pyridinium radioligand striatal terminals tetrahydropyridine uptake
Tagcloud (Difference) ?		70k arginine asf clk cloning coexpressed contributing dipeptides nh2 pancreas phosphorylate preference preferred proline redistribution reversible rs sf2 similarities spliceosome splicing srpk2 stringent sty u1 uniquely ww	black c57 competitive concentrated depleting dopamine dopaminergic exerts inactivates intraneuronally irreversible irreversibly keeping kinetics label mazindol moiety mptp neurotoxin pargyline phenyl pretreatment protected pyridinium radioligand striatal terminals tetrahydropyridine uptake
Tagcloud (Intersection) ?