SRPK1 and PFN1

Number of citations of the paper that reports this interaction (PMID 23602568)
8

Data Source:
BioGRID (enzymatic study)

		SRPK1	PFN1
Gene Name		SRSF protein kinase 1	profilin 1
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Plasma Membrane Nuclear Matrix	Nucleus Cytosol Cytoskeleton Focal Adhesion Membrane Neuron Projection Synapse Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Poly(A) RNA Binding	Adenyl-nucleotide Exchange Factor Activity Actin Binding Receptor Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Rho GTPase Binding Poly(A) RNA Binding Proline-rich Region Binding
	Biological Process	MRNA Processing Protein Phosphorylation Chromosome Segregation RNA Splicing Viral Process Sperm Chromatin Condensation Intracellular Signal Transduction Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Innate Immune Response Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing	Neural Tube Closure Platelet Degranulation Blood Coagulation Positive Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Platelet Activation Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription Positive Regulation Of DNA Metabolic Process Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Cellular Response To Growth Factor Stimulus Positive Regulation Of Ruffle Assembly
Pathways			Axon guidance Response to elevated platelet cytosolic Ca2+ Platelet degranulation Signaling by Wnt Platelet activation, signaling and aggregation Signaling by Robo receptor PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		174 interactors: ADPRH AHCYL1 ALKBH3 AMMECR1L APEX1 APP ARGLU1 ARHGAP12 ARHGAP26 ARL6IP4 ASAH1 ASXL1 AURKA AURKC C11orf52 C11orf63 C11orf87 C16orf78 C18orf25 C9orf72 CACNB1 CAMK2D CBX5 CDC42EP3 CDK7 CDKL3 CHEK2 CHERP CHUK CIAO1 CLIC5 CLK1 CLK4 CRHR1 CSAG1 DAW1 DDX47 DGCR8 DHX8 DHX9 DNAJC8 DUSP6 ECM1 EIF3M EPB41L4A EPHA3 ERBB2 ESRRG FAM124A FAM76B FERMT1 FGF12 FHL1 FKBP3 FLOT1 FLT1 GABARAP GABARAPL1 H2AFY HBS1L HIRIP3 HMGN3 HNRNPA1 IFIT5 IKBKG KCNAB1 KCNN2 KIAA1841 KPNA2 KPTN KRR1 LAMC1 LARP1 LBR LCE3D LIMK1 LINC00312 LUC7L LUC7L2 LUC7L3 MAGEB1 MAOB MAP1LC3A MAPK12 MAPK14 MAPKAPK5 MBNL3 MBP MRPL43 MRPS11 NCK2 NELFE NKAP NOL4L NOP16 NOVA1 NSMCE4A NSRP1 NUDT21 NXT2 OCEL1 ODF3L2 OR6B3 PAK4 PDGFRA PDPK1 PELI1 PELI2 PEX19 PFN1 PHF7 POLR2E PPIA PPIL1 PRM1 PRPF38A PTK2 RBM23 RBM39 RBM8A RBMS2 RIMS4 RNPS1 RPS6KB2 RSRC1 RSRC2 RSRP1 SAFB SCAF11 SEC23B SERPINB10 SETD3 SFMBT1 SLAIN2 SLC4A1AP SNRNP70 SPANXN4 SPATS2 SREK1 SRPK3 SRRM1 SRSF1 SRSF12 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 STAU1 STK26 SUDS3 TAF1B TFEB TNFRSF10C TOP2A TRA2B TRIM65 U2AF1 U2AF2 UBD UBE2E2 USP39 VANGL1 VDR WDR55 YPEL2 YTHDC1 YWHAG ZMYND11 ZNF444 ZNF514 ZRANB2 ZRSR2	30 interactors: ACTA1 ACTB APBB1IP C14orf1 CMA1 CRMP1 DBN1 DLG5 DNM2 ENAH FMNL1 GPHN LRIF1 MLLT4 MYPOP NCK1 PIK3R1 RAD51 RHOQ SRPK1 STUB1 TLE1 UNC119 VASP VIPR1 WASF1 WASL WIPF2 XPO6 YWHAQ
Entrez ID		6732	5216
HPRD ID		15992	01452
Ensembl ID		ENSG00000096063	ENSG00000108518
Uniprot IDs		B4DS61 Q96SB4	P07737
PDB IDs		1WAK 1WBP 3BEG	1AWI 1CF0 1CJF 1FIK 1FIL 1PFL 2PAV 2PBD 3CHW
Enriched GO Terms of Interacting Partners?		MRNA Processing RNA Processing RNA Splicing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Gene Expression RNA Metabolic Process DNA-templated Transcription, Termination Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Termination Of RNA Polymerase II Transcription Heterocycle Metabolic Process Cellular Metabolic Process MRNA 3'-end Processing Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Splicing Nitrogen Compound Metabolic Process RNA 3'-end Processing Spliceosomal Complex Assembly RNA Export From Nucleus Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Export From Nucleus RNA Localization Nuclear Export MRNA Transport RNA Transport Nucleocytoplasmic Transport Nuclear Transport MRNA Splice Site Selection Ribonucleoprotein Complex Biogenesis Cellular Process Ribonucleoprotein Complex Assembly Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of Gene Expression Protein Autophosphorylation Cytoplasmic Transport Regulation Of Alternative MRNA Splicing, Via Spliceosome Posttranscriptional Regulation Of Gene Expression Cellular Component Assembly Transcription, DNA-templated Metabolic Process Cellular Macromolecular Complex Assembly Regulation Of Metabolic Process RNA Biosynthetic Process Protein Phosphorylation Positive Regulation Of Viral Process Regulation Of Nitrogen Compound Metabolic Process	Actin Cytoskeleton Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Actin Filament-based Process Actin Filament Organization Cellular Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Communication Signal Transduction Immune Response-regulating Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Regulation Of Cellular Component Organization Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Membrane Tubulation Response To Stimulus Signaling Actin Polymerization Or Depolymerization Midbrain Development Cytoskeleton Organization Axon Guidance Movement Of Cell Or Subcellular Component Nervous System Development T Cell Receptor Signaling Pathway Positive Regulation Of Immune Response Neuron Projection Morphogenesis Endocytosis Anatomical Structure Development Phagocytosis Fc Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Axonogenesis System Development Cell Development Positive Regulation Of Actin Nucleation Neuron Projection Development Cellular Component Assembly Axon Development Cell Projection Morphogenesis Developmental Process Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Immune Response Regulation Of Actin Cytoskeleton Organization Chemotaxis Positive Regulation Of Immune System Process Cell Differentiation Regulation Of Clathrin-mediated Endocytosis Locomotion
Tagcloud ?		70k arginine asf clk cloning coexpressed contributing dipeptides nh2 pancreas phosphorylate preference preferred proline redistribution reversible rs sf2 similarities spliceosome splicing srpk2 stringent sty u1 uniquely ww	a20t adds aggregation als amyotrophic classic dementia demonstrating displayed e117g fatal frontotemporal hallmark heterogeneity insoluble lateral meta neurodegenerative pathology postmortem profilin published q139l rare sclerosis sequenced tar transfections variant
Tagcloud (Difference) ?		70k arginine asf clk cloning coexpressed contributing dipeptides nh2 pancreas phosphorylate preference preferred proline redistribution reversible rs sf2 similarities spliceosome splicing srpk2 stringent sty u1 uniquely ww	a20t adds aggregation als amyotrophic classic dementia demonstrating displayed e117g fatal frontotemporal hallmark heterogeneity insoluble lateral meta neurodegenerative pathology postmortem profilin published q139l rare sclerosis sequenced tar transfections variant
Tagcloud (Intersection) ?