SRPK1 and NSRP1

Number of citations of the paper that reports this interaction (PubMedID 23602568)
0

Data Source:
BioGRID (enzymatic study)

		SRPK1	NSRP1
Description		SRSF protein kinase 1	nuclear speckle splicing regulatory protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Nuclear Matrix Nuclear Speck	Nucleus Nucleoplasm Nuclear Speck Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	RNA Binding MRNA Binding Protein Binding
	Biological Process	Spliceosomal Complex Assembly MRNA Processing Protein Phosphorylation Chromosome Segregation RNA Splicing Cell Differentiation Sperm DNA Condensation Intracellular Signal Transduction Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Innate Immune Response Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing	Regulation Of Alternative MRNA Splicing, Via Spliceosome In Utero Embryonic Development MRNA Processing RNA Splicing Developmental Process
Pathways		Maturation of nucleoprotein Replacement of protamines by nucleosomes in the male pronucleus	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Antidepressant treatment resistance (> 2 drugs prescribed) ( 30700811) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494)	Brain morphology (MOSTest) ( 32665545) QRS complex (12-leadsum) ( 27659466)
Interacting Genes		167 interacting genes: ADPRH AHCYL1 ALKBH3 AMMECR1L APEX1 APP ARGLU1 ARHGAP12 ARHGAP26 ARK2N ASAH1 ASXL1 AURKA AURKC C11orf52 C11orf87 C16orf78 C9orf72 CACNB1 CAMK2D CBX5 CDC42EP3 CDK7 CDKL3 CHEK2 CHERP CHUK CIAO1 CIMAP1D CLIC5 CLK1 CLK4 CRHR1 CSAG1 DAW1 DDX47 DHX8 DHX9 DNAJC8 DUSP6 ECM1 EIF3M EPB41L4A EPHA3 ERBB2 ESRRG FAM124A FAM76B FERMT1 FGF12 FHL1 FKBP3 FLOT1 FLT1 GABARAP GABARAPL1 HBS1L HIRIP3 HMGN3 HNRNPA1 IFIT5 IKBKG JHY KCNAB1 KCNN2 KPNA2 KPTN KRR1 LAMC1 LARP1 LBR LCE3D LIMK1 LINC00312 LUC7L3 MACROH2A1 MAGEB1 MAOB MAP1LC3A MAPK12 MAPK14 MAPKAPK5 MAPT MBNL3 MBP MRPL43 MRPS11 NCK2 NELFE NKAP NOL4L NOP16 NOVA1 NSMCE4A NSRP1 NUDT21 NXT2 OCEL1 OR6B3 PAK4 PDGFRA PDPK1 PELI1 PELI2 PEX19 PFN1 PHF7 POLR2E PPIA PPIL1 PRM1 PRPF38A PTK2 RBM23 RBMS2 RIMS4 RPS6KB2 RSRC1 RSRC2 RSRP1 SAFB SANBR SCAF11 SEC23B SERPINB10 SETD3 SFMBT1 SLAIN2 SLC4A1AP SNRNP70 SPANXN4 SPATS2 SREK1 SRRM1 SRSF1 SRSF10 SRSF12 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 STAU1 STK26 SUDS3 TAF1B TFEB TNFRSF10C TOP2A TRA2B TRIM65 U2AF1 U2AF2 UBD UBE2E2 USP7 VANGL1 VDR WDR55 YPEL2 YTHDC1 YWHAG ZMYND11 ZNF444 ZNF514 ZRANB2	11 interacting genes: APP CNR1 CNRIP1 CTNNBL1 DISC1 FBXO25 NEDD4 NEDD4L RANBP9 SRPK1 SRPK2
Entrez ID		6732	84081
HPRD ID		15992	08536
Ensembl ID		ENSG00000096063	ENSG00000126653
Uniprot IDs		Q96SB4	A0A024QZ33 B7ZL27 Q9H0G5
PDB IDs		1WAK 1WBP 3BEG 4WUA 5MXX 5MY8 5NNG 5XV7 6FAD 7DD1 7PQS 7ZKS
Enriched GO Terms of Interacting Partners?		RNA Splicing Regulation Of MRNA Processing MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome RNA Binding Regulation Of RNA Splicing MRNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of MRNA Metabolic Process RNA Processing RNA Splicing, Via Transesterification Reactions Nucleoplasm Nucleus MRNA Binding Nuclear Speck Nucleic Acid Metabolic Process RNA Metabolic Process MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Nucleic Acid Binding Protein Kinase Activity Negative Regulation Of MRNA Metabolic Process MRNA Splice Site Recognition Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome RS Domain Binding Kinase Activity Negative Regulation Of RNA Splicing Spliceosomal Complex Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Gene Expression Protein-RNA Complex Assembly Pre-mRNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Alternative MRNA Splicing, Via Spliceosome Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific MRNA Binding Main Axon Response To Starvation Regulation Of Toll Signaling Pathway Catalytic Step 2 Spliceosome Protein Autophosphorylation IkappaB Kinase Complex Positive Regulation Of Viral Process Protein Phosphorylation Positive Regulation Of RNA Splicing	Presynapse Negative Regulation Of Potassium Ion Export Across Plasma Membrane Sodium Channel Inhibitor Activity Potassium Channel Inhibitor Activity Regulation Of Synapse Organization GABA-ergic Synapse Negative Regulation Of Sodium Ion Transport Regulation Of Potassium Ion Export Across Plasma Membrane Ubiquitin Ligase Complex Cytoplasm Receptor Catabolic Process Positive Regulation Of Protein Metabolic Process Enzyme Binding Negative Regulation Of Potassium Ion Transmembrane Transport Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Amyloid Precursor Protein Catabolic Process Neuron Projection Development Negative Regulation Of Potassium Ion Transport Positive Regulation Of Viral Genome Replication Neuromuscular Junction Development Positive Regulation Of Protein Catabolic Process Positive Regulation Of Catabolic Process Glutamatergic Synapse Amyloid-beta Complex Regulation Of Plasma Membrane Bounded Cell Projection Organization Immune Response Regulation Of Amyloid Precursor Protein Catabolic Process Innate Immune Response Growth Cone Lamellipodium Regulation Of Cell Projection Organization Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Neuron Recognition Cell Projection Organization Regulation Of Monoatomic Cation Transmembrane Transport Synapse Organization Receptor Metabolic Process Ubiquitin-protein Transferase Activity Protein Monoubiquitination Formation Of Structure Involved In A Symbiotic Process Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Type 1 Cannabinoid Receptor Binding Protein Metabolic Process Regulation Of Monoatomic Ion Transmembrane Transport Neuron Cellular Homeostasis Regulation Of Dendrite Morphogenesis Positive Regulation Of Viral Process Regulation Of Potassium Ion Transmembrane Transport
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