SRPK1 and RPS6KB2

Number of citations of the paper that reports this interaction (PubMedID 23602568)
0

Data Source:
BioGRID (enzymatic study)

		SRPK1	RPS6KB2
Description		SRSF protein kinase 1	ribosomal protein S6 kinase B2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Nuclear Matrix Nuclear Speck	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Nucleotide Binding Magnesium Ion Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity ATP Binding Kinase Activity Transferase Activity Peptide Binding Protein Serine Kinase Activity
	Biological Process	Spliceosomal Complex Assembly MRNA Processing Protein Phosphorylation Chromosome Segregation RNA Splicing Cell Differentiation Sperm DNA Condensation Intracellular Signal Transduction Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Innate Immune Response Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing	Cytoplasmic Translation Translation Signal Transduction TOR Signaling TORC1 Signaling Positive Regulation Of Translational Initiation Negative Regulation Of Insulin Receptor Signaling Pathway
Pathways		Maturation of nucleoprotein Replacement of protamines by nucleosomes in the male pronucleus	AKT phosphorylates targets in the nucleus Constitutive Signaling by AKT1 E17K in Cancer
Drugs
Diseases
GWAS		Antidepressant treatment resistance (> 2 drugs prescribed) ( 30700811) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494)	Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		167 interacting genes: ADPRH AHCYL1 ALKBH3 AMMECR1L APEX1 APP ARGLU1 ARHGAP12 ARHGAP26 ARK2N ASAH1 ASXL1 AURKA AURKC C11orf52 C11orf87 C16orf78 C9orf72 CACNB1 CAMK2D CBX5 CDC42EP3 CDK7 CDKL3 CHEK2 CHERP CHUK CIAO1 CIMAP1D CLIC5 CLK1 CLK4 CRHR1 CSAG1 DAW1 DDX47 DHX8 DHX9 DNAJC8 DUSP6 ECM1 EIF3M EPB41L4A EPHA3 ERBB2 ESRRG FAM124A FAM76B FERMT1 FGF12 FHL1 FKBP3 FLOT1 FLT1 GABARAP GABARAPL1 HBS1L HIRIP3 HMGN3 HNRNPA1 IFIT5 IKBKG JHY KCNAB1 KCNN2 KPNA2 KPTN KRR1 LAMC1 LARP1 LBR LCE3D LIMK1 LINC00312 LUC7L3 MACROH2A1 MAGEB1 MAOB MAP1LC3A MAPK12 MAPK14 MAPKAPK5 MAPT MBNL3 MBP MRPL43 MRPS11 NCK2 NELFE NKAP NOL4L NOP16 NOVA1 NSMCE4A NSRP1 NUDT21 NXT2 OCEL1 OR6B3 PAK4 PDGFRA PDPK1 PELI1 PELI2 PEX19 PFN1 PHF7 POLR2E PPIA PPIL1 PRM1 PRPF38A PTK2 RBM23 RBMS2 RIMS4 RPS6KB2 RSRC1 RSRC2 RSRP1 SAFB SANBR SCAF11 SEC23B SERPINB10 SETD3 SFMBT1 SLAIN2 SLC4A1AP SNRNP70 SPANXN4 SPATS2 SREK1 SRRM1 SRSF1 SRSF10 SRSF12 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 STAU1 STK26 SUDS3 TAF1B TFEB TNFRSF10C TOP2A TRA2B TRIM65 U2AF1 U2AF2 UBD UBE2E2 USP7 VANGL1 VDR WDR55 YPEL2 YTHDC1 YWHAG ZMYND11 ZNF444 ZNF514 ZRANB2	22 interacting genes: BTK CFTR COASY EEF2K EP300 FBXO25 FYN HNRNPA1 IKBKG KAT2B LRRK2 LYN MAPK8IP2 MTOR NEDD4L PDGFRB PDPK1 PRKCE RPS6 SRC SRPK1 SYK
Entrez ID		6732	6199
HPRD ID		15992	10203
Ensembl ID		ENSG00000096063	ENSG00000175634
Uniprot IDs		Q96SB4	Q9UBS0
PDB IDs		1WAK 1WBP 3BEG 4WUA 5MXX 5MY8 5NNG 5XV7 6FAD 7DD1 7PQS 7ZKS
Enriched GO Terms of Interacting Partners?		RNA Splicing Regulation Of MRNA Processing MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome RNA Binding Regulation Of RNA Splicing MRNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of MRNA Metabolic Process RNA Processing RNA Splicing, Via Transesterification Reactions Nucleoplasm Nucleus MRNA Binding Nuclear Speck Nucleic Acid Metabolic Process RNA Metabolic Process MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Nucleic Acid Binding Protein Kinase Activity Negative Regulation Of MRNA Metabolic Process MRNA Splice Site Recognition Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome RS Domain Binding Kinase Activity Negative Regulation Of RNA Splicing Spliceosomal Complex Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Gene Expression Protein-RNA Complex Assembly Pre-mRNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Alternative MRNA Splicing, Via Spliceosome Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific MRNA Binding Main Axon Response To Starvation Regulation Of Toll Signaling Pathway Catalytic Step 2 Spliceosome Protein Autophosphorylation IkappaB Kinase Complex Positive Regulation Of Viral Process Protein Phosphorylation Positive Regulation Of RNA Splicing	Cellular Response To Oxygen-containing Compound Protein Phosphorylation Kinase Activity Protein Kinase Activity Phosphorylation Transferase Activity Positive Regulation Of Cellular Component Organization Protein Modification Process Phospholipase Binding Peptidyl-tyrosine Phosphorylation Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Signaling Pathway ATP Binding Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Protein Tyrosine Kinase Activity Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Cellular Response To Stress Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Activation Fc-gamma Receptor Signaling Pathway Phospholipase Activator Activity Protein Metabolic Process Phosphate-containing Compound Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Nucleotide Binding Response To Hormone Regulation Of Innate Immune Response Innate Immune Response-activating Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Response To Peptide Hormone T Cell Costimulation Cytoplasm Response To Stress Activation Of Innate Immune Response Positive Regulation Of Lymphocyte Activation Regulation Of Transport Immune Response-activating Signaling Pathway Protein Autophosphorylation Positive Regulation Of Signal Transduction Regulation Of Vesicle-mediated Transport Positive Regulation Of Immune System Process Regulation Of Cellular Component Organization Transmembrane Transporter Binding Cellular Response To Nutrient Levels
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