SRPK1 and PPIA

Number of citations of the paper that reports this interaction (PubMedID 23602568)
0

Data Source:
BioGRID (enzymatic study)

		SRPK1	PPIA
Description		SRSF protein kinase 1	peptidylprolyl isomerase A
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Nuclear Matrix Nuclear Speck	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Focal Adhesion Membrane Vesicle Protein-containing Complex Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Nucleotide Binding Magnesium Ion Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Integrin Binding Protein Binding Cyclosporin A Binding Isomerase Activity Virion Binding Unfolded Protein Binding Heparan Sulfate Binding
	Biological Process	Spliceosomal Complex Assembly MRNA Processing Protein Phosphorylation Chromosome Segregation RNA Splicing Cell Differentiation Sperm DNA Condensation Intracellular Signal Transduction Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Innate Immune Response Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing	Protein Peptidyl-prolyl Isomerization Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Protein Folding Negative Regulation Of Protein Kinase Activity Apoptotic Process Viral Release From Host Cell Platelet Activation Neuron Differentiation Neutrophil Chemotaxis Leukocyte Chemotaxis Activation Of Protein Kinase B Activity Negative Regulation Of Stress-activated MAPK Cascade Lipid Droplet Organization Cellular Response To Oxidative Stress Endothelial Cell Activation Positive Regulation Of MAPK Cascade Regulation Of Viral Genome Replication Positive Regulation Of Viral Genome Replication Positive Regulation Of Protein Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Adhesion Molecule Production Negative Regulation Of Protein K48-linked Ubiquitination Platelet Aggregation Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Viral Life Cycle Regulation Of Apoptotic Signaling Pathway
Pathways		Maturation of nucleoprotein Replacement of protamines by nucleosomes in the male pronucleus	Platelet degranulation Uncoating of the HIV Virion Budding and maturation of HIV virion Integration of provirus Early Phase of HIV Life Cycle Minus-strand DNA synthesis Plus-strand DNA synthesis Binding and entry of HIV virion Assembly Of The HIV Virion APOBEC3G mediated resistance to HIV-1 infection Calcineurin activates NFAT Basigin interactions Neutrophil degranulation Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation SARS-CoV-1 activates/modulates innate immune responses
Drugs			Cyclosporine Proline (3r)-1-Acetyl-3-Methylpiperidine Ethyl Oxo(Piperidin-1-Yl)Acetate Sanglifehrin A Copper Artenimol
Diseases
GWAS		Antidepressant treatment resistance (> 2 drugs prescribed) ( 30700811) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494)	Mean reticulocyte volume ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		167 interacting genes: ADPRH AHCYL1 ALKBH3 AMMECR1L APEX1 APP ARGLU1 ARHGAP12 ARHGAP26 ARK2N ASAH1 ASXL1 AURKA AURKC C11orf52 C11orf87 C16orf78 C9orf72 CACNB1 CAMK2D CBX5 CDC42EP3 CDK7 CDKL3 CHEK2 CHERP CHUK CIAO1 CIMAP1D CLIC5 CLK1 CLK4 CRHR1 CSAG1 DAW1 DDX47 DHX8 DHX9 DNAJC8 DUSP6 ECM1 EIF3M EPB41L4A EPHA3 ERBB2 ESRRG FAM124A FAM76B FERMT1 FGF12 FHL1 FKBP3 FLOT1 FLT1 GABARAP GABARAPL1 HBS1L HIRIP3 HMGN3 HNRNPA1 IFIT5 IKBKG JHY KCNAB1 KCNN2 KPNA2 KPTN KRR1 LAMC1 LARP1 LBR LCE3D LIMK1 LINC00312 LUC7L3 MACROH2A1 MAGEB1 MAOB MAP1LC3A MAPK12 MAPK14 MAPKAPK5 MAPT MBNL3 MBP MRPL43 MRPS11 NCK2 NELFE NKAP NOL4L NOP16 NOVA1 NSMCE4A NSRP1 NUDT21 NXT2 OCEL1 OR6B3 PAK4 PDGFRA PDPK1 PELI1 PELI2 PEX19 PFN1 PHF7 POLR2E PPIA PPIL1 PRM1 PRPF38A PTK2 RBM23 RBMS2 RIMS4 RPS6KB2 RSRC1 RSRC2 RSRP1 SAFB SANBR SCAF11 SEC23B SERPINB10 SETD3 SFMBT1 SLAIN2 SLC4A1AP SNRNP70 SPANXN4 SPATS2 SREK1 SRRM1 SRSF1 SRSF10 SRSF12 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 STAU1 STK26 SUDS3 TAF1B TFEB TNFRSF10C TOP2A TRA2B TRIM65 U2AF1 U2AF2 UBD UBE2E2 USP7 VANGL1 VDR WDR55 YPEL2 YTHDC1 YWHAG ZMYND11 ZNF444 ZNF514 ZRANB2	30 interacting genes: APP BSG CD99 ERCC6 ERRFI1 G3BP1 GRSF1 ITK JAK2 LIG4 LNX1 N4BP2L2 NOTCH3 PAXIP1 PDE4B PRLR PRR13 PRSS23 PTPRN RB1 S100A8 SRPK1 SRPK2 SUPT5H TCF4 TERT UBE3A USP4 WBP4 YY1
Entrez ID		6732	5478
HPRD ID		15992	00457
Ensembl ID		ENSG00000096063	ENSG00000196262
Uniprot IDs		Q96SB4	P62937 V9HWF5
PDB IDs		1WAK 1WBP 3BEG 4WUA 5MXX 5MY8 5NNG 5XV7 6FAD 7DD1 7PQS 7ZKS	1AK4 1AWQ 1AWR 1AWS 1AWT 1AWU 1AWV 1BCK 1CWA 1CWB 1CWC 1CWF 1CWH 1CWI 1CWJ 1CWK 1CWL 1CWM 1CWO 1FGL 1M63 1M9C 1M9D 1M9E 1M9F 1M9X 1M9Y 1MF8 1MIK 1NMK 1OCA 1RMH 1VBS 1VBT 1W8L 1W8M 1W8V 1YND 1ZKF 2ALF 2CPL 2CYH 2MS4 2MZU 2N0T 2RMA 2RMB 2X25 2X2A 2X2C 2X2D 2XGY 3CYH 3CYS 3K0M 3K0N 3K0O 3K0P 3K0Q 3K0R 3ODI 3ODL 3RDD 4CYH 4IPZ 4N1M 4N1N 4N1O 4N1P 4N1Q 4N1R 4N1S 4YUG 4YUH 4YUI 4YUJ 4YUK 4YUL 4YUM 4YUN 4YUO 4YUP 5CYH 5F66 5FJB 5KUL 5KUN 5KUO 5KUQ 5KUR 5KUS 5KUU 5KUV 5KUW 5KUZ 5KV0 5KV1 5KV2 5KV3 5KV4 5KV5 5KV6 5KV7 5LUD 5NOQ 5NOR 5NOS 5NOT 5NOU 5NOV 5NOW 5NOX 5NOY 5NOZ 5T9U 5T9W 5T9Z 5TA2 5TA4 5WC7 6BTA 6GJI 6GJJ 6GJL 6GJM 6GJN 6GJP 6GJR 6GJY 6GS6 6I42 6U5C 6U5D 6U5E 6U5G 6X3R 6X3Y 6X4M 6X4N 6X4O 6X4P 6X4Q 6Y9V 6Y9W 6Y9X 6Y9Y 6Y9Z 6ZDJ 7ABT 7N9X 7PCJ 7QBW 7TA8 7UPN 7UXJ 7UXM 7UXN 8G9P 8G9Q 8HZ8 8TBF 8TBG 8TBH 8TBI 8TBJ 8TBK 8TBL 8TBM 8TBN 9AX6 9BFW 9BFY 9BFZ 9BG1 9BHO 9BHP 9BHQ 9BI1 9BI2 9GHY
Enriched GO Terms of Interacting Partners?		RNA Splicing Regulation Of MRNA Processing MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome RNA Binding Regulation Of RNA Splicing MRNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of MRNA Metabolic Process RNA Processing RNA Splicing, Via Transesterification Reactions Nucleoplasm Nucleus MRNA Binding Nuclear Speck Nucleic Acid Metabolic Process RNA Metabolic Process MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Nucleic Acid Binding Protein Kinase Activity Negative Regulation Of MRNA Metabolic Process MRNA Splice Site Recognition Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome RS Domain Binding Kinase Activity Negative Regulation Of RNA Splicing Spliceosomal Complex Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Gene Expression Protein-RNA Complex Assembly Pre-mRNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Alternative MRNA Splicing, Via Spliceosome Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific MRNA Binding Main Axon Response To Starvation Regulation Of Toll Signaling Pathway Catalytic Step 2 Spliceosome Protein Autophosphorylation IkappaB Kinase Complex Positive Regulation Of Viral Process Protein Phosphorylation Positive Regulation Of RNA Splicing	Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Developmental Process Nucleus Positive Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Endosome Lumen Regulation Of MiRNA Transcription Regulation Of Protein Modification Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process Activation Of Janus Kinase Activity Intracellular Signal Transduction Regulation Of Cell Differentiation Immune System Process Regulation Of RNA Metabolic Process Regulation Of Cytokine Production Regulation Of Primary Metabolic Process Regulation Of Neuron Apoptotic Process Chromatin Organization Response To Stress Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Signaling Receptor Activator Activity Embryo Implantation Nucleic Acid Metabolic Process Immunoglobulin V(D)J Recombination Chromatin Remodeling Neutrophil Chemotaxis Hormone-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Prostate Gland Growth Cellular Developmental Process Regulation Of Nucleobase-containing Compound Metabolic Process Neuron Projection Development Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair Mammary Gland Epithelium Development Nucleobase-containing Compound Metabolic Process Positive Regulation Of Viral Process
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