SMS and MAPK6

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		SMS	MAPK6
Description		spermine synthase	mitogen-activated protein kinase 6
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Septin Cytoskeleton Protein-containing Complex
	Molecular Function	Transferase Activity Spermine Synthase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Heterodimerization Activity Protein Serine Kinase Activity
	Biological Process	Methionine Metabolic Process Polyamine Metabolic Process Polyamine Biosynthetic Process Spermine Biosynthetic Process Spermine Metabolic Process	MAPK Cascade Protein Phosphorylation Signal Transduction Intracellular Signal Transduction Positive Regulation Of Dendritic Spine Development
Pathways		Metabolism of polyamines	MAPK6/MAPK4 signaling
Drugs		Spermine	Acetylsalicylic acid Minocycline Colforsin
Diseases		Snyder-Robinson syndrome
GWAS			Frailty index ( 34431594) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		6 interacting genes: CEBPA EZH2 MAPK6 MAPK8IP2 MAPKAPK3 RPS6KA3	167 interacting genes: ACTG1 ACTR1B AMPH ANAPC5 ANK3 ANKRD2 APBA2 ARHGDIA ARPC3 ATG9A ATP5PF BAG6 BARX1 BBS10 BTRC CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFAP298 CFL1 CNTN1 CNTRL COPS6 CSE1L CYRIB CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DST DYNC2I2 EDF1 EEF1A2 EIF1 EIF3C EIF4A1 ELOF1 EMD FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NAXE NDUFS6 NECTIN2 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 RAB2A RAB31 RACK1 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPTIN3 SEPTIN5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 USP20 VPS26C WDR26 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775
Entrez ID		6611	5597
HPRD ID		02115	04213
Ensembl ID		ENSG00000102172	ENSG00000069956
Uniprot IDs		P52788	Q16659
PDB IDs		3C6K 3C6M	6YKY 6YLC 6YLL 7AQB
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of Transcription Elongation By RNA Polymerase II Intracellular Signaling Cassette Response To Lipid Intracellular Signal Transduction Animal Organ Regeneration MAPK Cascade Toll-like Receptor Signaling Pathway RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Hepatocyte Homeostasis Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity U6 2'-O-snRNA Methylation Nucleoplasm Chromatin DNA Binding Response To Vitamin B2 Positive Regulation Of Defense Response Liver Development C/EBP Complex Cellular Response To Trichostatin A Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Septin Cytoskeleton Protein Kinase Binding Protein Kinase Activity CHOP-C/EBP Complex Positive Regulation Of Developmental Process Regeneration Histone H3K27 Trimethyltransferase Activity Response To Tetrachloromethane Box C/D Sno(s)RNA 3'-end Processing Kinase Activity White Fat Cell Proliferation Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Positive Regulation Of SnRNA Transcription By RNA Polymerase II 7SK SnRNP Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Histone H3K27 Methyltransferase Activity Innate Immune Response-activating Signaling Pathway Ribosomal Protein S6 Kinase Activity Calcium-dependent Protein Serine/threonine Kinase Activity SnRNA Modification Response To Phenylpropanoid Protein-containing Complex Pronucleus Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Transferase Activity Methylation	Cytosol Cytoplasm Nucleus Protein Binding Extracellular Exosome Ubiquitin Protein Ligase Binding
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