SMS and RPS6KA3

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		SMS	RPS6KA3
Gene Name		spermine synthase	ribosomal protein S6 kinase, 90kDa, polypeptide 3
Image
Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome	Nucleoplasm Cytosol
	Molecular Function	Spermidine Synthase Activity Spermine Synthase Activity	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Methionine Metabolic Process Polyamine Metabolic Process Spermine Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process	Skeletal System Development Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Cell Cycle Signal Transduction Synaptic Transmission Axon Guidance Central Nervous System Development Positive Regulation Of Cell Growth Response To Lipopolysaccharide Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Translation In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Innate Immune Response Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade
Pathways		Metabolism of polyamines Metabolism of amino acids and derivatives	Signaling by GPCR CREB phosphorylation Axon guidance Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence CREB phosphorylation L1CAM interactions Recycling pathway of L1 CREB phosphorylation through the activation of Ras Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK RSK activation Activation of NMDA receptor upon glutamate binding and postsynaptic events MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ERK/MAPK targets Post NMDA receptor activation events Innate Immune System Signalling by NGF MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling Senescence-Associated Secretory Phenotype (SASP) NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade ERK/MAPK targets Toll Like Receptor 3 (TLR3) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Transmission across Chemical Synapses Nuclear Events (kinase and transcription factor activation)
Drugs		Spermine
Diseases
GWAS
Protein-Protein Interactions		5 interactors: EZH2 MAPK6 MAPK8IP2 MAPKAPK3 RPS6KA3	32 interactors: ATP5J BAD BARX1 CREB1 CREBBP EIF3C ESR1 FGF2 FGFR1 GRIN1 GRIN2D H2AFX HIST1H3A HIST3H3 HMGN1 HMGN2 HTR2A KRT18 MAGI1 MAPK1 MAPK3 MAPT MASP1 NEDD4 NFKBIA NR4A1 PDPK1 PEA15 SHANK1 SMS STK11 YBX1
Entrez ID		6611	6197
HPRD ID		02115	02092
Ensembl ID		ENSG00000102172	ENSG00000177189
Uniprot IDs		B4DE40 P52788	B7ZB17 F5GYC4 P51812
PDB IDs		3C6K 3C6M	4D9T 4D9U 4JG6 4JG7 4JG8
Enriched GO Terms of Interacting Partners?		MAPK Cascade Signal Transduction By Phosphorylation Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of MAPK Cascade TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Kinase Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Response To Stress Positive Regulation Of Kinase Activity MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Transferase Activity Regulation Of MAPK Cascade Phosphorylation Intracellular Signal Transduction Toll-like Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Protein Metabolic Process Activation Of Innate Immune Response Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Catalytic Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Innate Immune Response Positive Regulation Of Cellular Metabolic Process Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Neurotrophin Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Nonassociative Learning Macropinocytosis Phosphate-containing Compound Metabolic Process Regulation Of Innate Immune Response Positive Regulation Of Protein Metabolic Process	Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Organonitrogen Compound Immune Response-regulating Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Differentiation Innate Immune Response Cell Death Death Regulation Of Signaling Cell Surface Receptor Signaling Pathway Response To Abiotic Stimulus Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Phospholipase C Activity Response To Organic Substance Positive Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Cellular Biosynthetic Process Immune Response Insulin Receptor Signaling Pathway Response To Growth Factor Regulation Of Signal Transduction Anatomical Structure Morphogenesis Response To Peptide Immune System Process Cell Development Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Response To Stress Regulation Of Metabolic Process Response To Hormone Cellular Response To Organic Substance Apoptotic Process Cellular Response To Insulin Stimulus Programmed Cell Death
Tagcloud ?		2q11 2q21 arm boy c130g3 cmt1a d17s258 d17s29 d17s446 d17s58 der fli hybridizations hypoplasia illustrates ins inserted insertional intrachromosomal magenis metacentric midfacial p11 proximally q11 q21 rearrangement smith stature	aberrations applying arid2 axin1 cdk15 cps1 creating deleterious disruptions drive driver fn1 fusions genomes hccs hnf4a integrations intronic mll4 recurrently seq silent splice tert thrap3 transcriptomes transcriptomic tsc1 wgs
Tagcloud (Difference) ?		2q11 2q21 arm boy c130g3 cmt1a d17s258 d17s29 d17s446 d17s58 der fli hybridizations hypoplasia illustrates ins inserted insertional intrachromosomal magenis metacentric midfacial p11 proximally q11 q21 rearrangement smith stature	aberrations applying arid2 axin1 cdk15 cps1 creating deleterious disruptions drive driver fn1 fusions genomes hccs hnf4a integrations intronic mll4 recurrently seq silent splice tert thrap3 transcriptomes transcriptomic tsc1 wgs
Tagcloud (Intersection) ?