SMS and MAPK8IP2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		SMS	MAPK8IP2
Gene Name		spermine synthase	mitogen-activated protein kinase 8 interacting protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome	Cytoplasm Neuronal Cell Body Protein Complex Neuronal Postsynaptic Density
	Molecular Function	Spermidine Synthase Activity Spermine Synthase Activity	Beta-amyloid Binding MAP-kinase Scaffold Activity Structural Molecule Activity Protein Binding Kinesin Binding Protein Kinase Binding Protein Kinase Activator Activity Protein Complex Binding
	Biological Process	Methionine Metabolic Process Polyamine Metabolic Process Spermine Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process	MAPK Cascade Behavioral Fear Response Signal Complex Assembly JNK Cascade Mating Behavior Regulation Of Receptor Activity Positive Regulation Of Stress-activated MAPK Cascade Social Behavior Positive Regulation Of Protein Kinase Activity Regulation Of JNK Cascade Nonassociative Learning Dendrite Morphogenesis Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity
Pathways		Metabolism of polyamines Metabolism of amino acids and derivatives
Drugs		Spermine
Diseases
GWAS
Protein-Protein Interactions		5 interactors: EZH2 MAPK6 MAPK8IP2 MAPKAPK3 RPS6KA3	52 interactors: ADRB2 AFG3L2 APP ASRGL1 BBS10 C14orf1 CFL1 CHN1 CRMP1 DUSP16 EGFR ERBB2 EZH2 FGF12 FSCN1 GBP2 ITSN1 KIFC2 KLC1 LRP1 LRP2 LRP8 MAGED4B MAP2K3 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAPK10 MAPK8 MAPK8IP1 MAPK8IP3 MAPK9 MASP1 NDUFS6 PLXNA3 PRSS23 RAI1 RBX1 RPS6KB2 SMARCB1 SMS SYNE2 TIAM1 TP53BP2 UNC119 VCP VPS33B VRK2 YY1AP1 ZNF593 ZNF784
Entrez ID		6611	23542
HPRD ID		02115	09674
Ensembl ID		ENSG00000102172	ENSG00000008735
Uniprot IDs		B4DE40 P52788	Q13387
PDB IDs		3C6K 3C6M
Enriched GO Terms of Interacting Partners?		MAPK Cascade Signal Transduction By Phosphorylation Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of MAPK Cascade TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Kinase Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Response To Stress Positive Regulation Of Kinase Activity MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Transferase Activity Regulation Of MAPK Cascade Phosphorylation Intracellular Signal Transduction Toll-like Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Protein Metabolic Process Activation Of Innate Immune Response Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Catalytic Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Innate Immune Response Positive Regulation Of Cellular Metabolic Process Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Neurotrophin Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Nonassociative Learning Macropinocytosis Phosphate-containing Compound Metabolic Process Regulation Of Innate Immune Response Positive Regulation Of Protein Metabolic Process	Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade JNK Cascade Signal Transduction By Phosphorylation MAPK Cascade Regulation Of Protein Kinase Activity Regulation Of MAPK Cascade Regulation Of Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity JUN Phosphorylation Regulation Of MAP Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Positive Regulation Of MAP Kinase Activity Response To Stress Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of MAPK Cascade Regulation Of Signal Transduction Response To Light Stimulus Response To External Stimulus Response To Radiation Regulation Of Signaling Intracellular Signal Transduction Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Axon Guidance Regulation Of Intracellular Signal Transduction Signal Transduction Axonogenesis Phosphorylation Cell Part Morphogenesis Axon Development Response To Stimulus Cell Morphogenesis Involved In Neuron Differentiation Response To Abiotic Stimulus Protein Phosphorylation Cellular Response To Stress Signaling
Tagcloud ?		2q11 2q21 arm boy c130g3 cmt1a d17s258 d17s29 d17s446 d17s58 der fli hybridizations hypoplasia illustrates ins inserted insertional intrachromosomal magenis metacentric midfacial p11 proximally q11 q21 rearrangement smith stature
Tagcloud (Difference) ?		2q11 2q21 arm boy c130g3 cmt1a d17s258 d17s29 d17s446 d17s58 der fli hybridizations hypoplasia illustrates ins inserted insertional intrachromosomal magenis metacentric midfacial p11 proximally q11 q21 rearrangement smith stature
Tagcloud (Intersection) ?