ZXDC and SH3GL2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		ZXDC	SH3GL2
Gene Name		ZXD family zinc finger C	SH3-domain GRB2-like 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Nucleus	Golgi Membrane Cytosol Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	Nucleic Acid Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding LRR Domain Binding Metal Ion Binding C2H2 Zinc Finger Domain Binding	Protein Binding Lipid Binding Identical Protein Binding
	Biological Process	Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated	Regulation Of Receptor Internalization Post-Golgi Vesicle-mediated Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Central Nervous System Development Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Synaptic Vesicle Endocytosis Membrane Organization
Pathways			Retrograde neurotrophin signalling EGFR downregulation Signalling by NGF Axon guidance Golgi Associated Vesicle Biogenesis L1CAM interactions Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer Recycling pathway of L1 Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Signaling by EGFR MHC class II antigen presentation Signaling by EGFR in Cancer trans-Golgi Network Vesicle Budding Adaptive Immune System
Drugs
Diseases
GWAS			Cognitive performance ( 19734545) Heart failure ( 20445134) Multiple sclerosis ( 19010793) Obesity-related traits ( 23251661) Parkinson's disease ( 22451204)
Protein-Protein Interactions		12 interactors: APP ATXN1 CIITA JTB NR1H2 NR1H3 POGZ RORA SH3GL2 SMN1 TK1 WDR5	53 interactors: ACTG1 ADAM15 ADAM19 ADRB1 AMPH APP ARNT2 ATXN2 BIN1 CD2AP CLEC3B DACT1 DLGAP4 DNM1 DNM2 DPPA4 DPYSL4 EGFL6 EMD ERH F13A1 GCH1 GSTM3 HLA-DQA1 IGHM IL6 ITCH ITSN1 LCP2 LRRK2 MAP4K3 MAST2 PAK2 PAXIP1 PDCD6IP PPP1R21 PPP6R1 PRR14 SH3GL1 SH3GL3 SH3KBP1 SLC17A7 SYN1 SYNJ1 SYNJ2 TCEA2 TERF1 TIAM2 TMEM108 TYMS ZNF219 ZNF580 ZXDC
Entrez ID		79364	6456
HPRD ID		14420	05125
Ensembl ID		ENSG00000070476	ENSG00000107295
Uniprot IDs		Q2QGD7	B7Z7W3 F5H5J3 Q7Z376 Q8IZ09 Q99962
PDB IDs			1X03 1X04 2D4C 2DBM
Enriched GO Terms of Interacting Partners?		Regulation Of Cholesterol Homeostasis Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Pinocytosis Intracellular Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Cholesterol Storage Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Lipid Homeostasis Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Lipoprotein Lipase Activity Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Transport Negative Regulation Of Macrophage Derived Foam Cell Differentiation RNA Metabolic Process Hormone-mediated Signaling Pathway Negative Regulation Of Lipid Storage Regulation Of Cholesterol Efflux Regulation Of Triglyceride Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Interferon-gamma-mediated Signaling Pathway Gene Expression Regulation Of Response To Interferon-gamma Negative Regulation Of Lipid Transport Response To Steroid Hormone Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Macrophage Activation Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Regulation Of Cellular Ketone Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Endocytosis Negative Regulation Of Signal Transduction Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Regulation Of Cholesterol Transport Triglyceride Homeostasis Acylglycerol Homeostasis Regulation Of Triglyceride Metabolic Process Negative Regulation Of Innate Immune Response Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Signaling	Endocytosis Developmental Process Neuron Projection Morphogenesis Neuron Projection Development Vesicle-mediated Transport Signaling Locomotion Cell Communication Cell Differentiation Cell-cell Signaling System Development Cell Projection Organization Positive Regulation Of Programmed Cell Death Neuron Development Positive Regulation Of Cell Death Response To Stimulus Cell Projection Morphogenesis Multicellular Organismal Development Cell Morphogenesis Cell Part Morphogenesis Nervous System Development Cell Development Neuron Differentiation Synaptic Transmission Positive Regulation Of Apoptotic Process Regulation Of Cellular Component Organization Chemotaxis Innate Immune Response Anatomical Structure Development Cell Death Platelet Activation Death Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Generation Of Neurons Response To External Stimulus Defense Response Synaptic Vesicle Transport Secretion By Cell Cellular Response To Stimulus Regulation Of Synaptic Vesicle Transport Positive Regulation Of Metabolic Process Cell Morphogenesis Involved In Differentiation Neurogenesis Regulation Of Vesicle-mediated Transport Response To Stress Signal Transduction Axon Guidance Apoptotic Process Regulation Of Apoptotic Process
Tagcloud ?			250k 9p22 affymetrix alteration array biopsies corresponding deleted evident forced heterozygosity informative interactor internalization invasion modulating mucosal nsclc nspi paired platform scanning ser ss transfected tyr understand usp9x validation
Tagcloud (Difference) ?			250k 9p22 affymetrix alteration array biopsies corresponding deleted evident forced heterozygosity informative interactor internalization invasion modulating mucosal nsclc nspi paired platform scanning ser ss transfected tyr understand usp9x validation
Tagcloud (Intersection) ?