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ZXDC and RORA
Number of citations of the paper that reports this interaction (PMID
15604093
)
36
Data Source:
HPRD
(two hybrid)
ZXDC
RORA
Gene Name
ZXD family zinc finger C
RAR-related orphan receptor A
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cellular_component
Nucleus
Nucleus
Nucleoplasm
Molecular Function
Nucleic Acid Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
LRR Domain Binding
Metal Ion Binding
C2H2 Zinc Finger Domain Binding
Core Promoter Sequence-specific DNA Binding
Transcription Corepressor Binding
Transcription Coactivator Binding
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Steroid Hormone Receptor Activity
Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity
Protein Binding
Beta-catenin Binding
Transcription Factor Binding
Oxysterol Binding
Zinc Ion Binding
Sequence-specific DNA Binding
Direct Ligand Regulated Sequence-specific DNA Binding Transcription Factor Activity
Biological Process
Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Angiogenesis
Regulation Of Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Xenobiotic Metabolic Process
Nitric Oxide Biosynthetic Process
Circadian Rhythm
Regulation Of Smoothened Signaling Pathway
Gene Expression
Positive Regulation Vascular Endothelial Growth Factor Production
Regulation Of Glucose Metabolic Process
Regulation Of Steroid Metabolic Process
Cerebellar Purkinje Cell Differentiation
Cerebellar Granule Cell Precursor Proliferation
Intracellular Receptor Signaling Pathway
Circadian Regulation Of Gene Expression
Cellular Response To Sterol
Muscle Cell Differentiation
Positive Regulation Of Circadian Rhythm
Regulation Of Macrophage Activation
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Steroid Hormone Mediated Signaling Pathway
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
CGMP Metabolic Process
Negative Regulation Of Inflammatory Response
Regulation Of Transcription Involved In Cell Fate Commitment
Triglyceride Homeostasis
Cellular Response To Hypoxia
T-helper 17 Cell Differentiation
Regulation Of Cholesterol Homeostasis
Pathways
PPARA activates gene expression
Fatty acid, triacylglycerol, and ketone body metabolism
Metabolism of lipids and lipoproteins
Generic Transcription Pathway
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
REV-ERBA represses gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
RORA activates circadian gene expression
Drugs
Diseases
GWAS
Asthma (
20860503
)
Breast cancer (prognosis) (
23319801
)
C-reactive protein (
21300955
)
Depression (quantitative trait) (
20800221
)
Gamma gluatamyl transferase levels (
22010049
)
Liver enzyme levels (gamma-glutamyl transferase) (
22001757
)
Menarche (age at onset) (
21102462
23599027
)
Pulmonary function decline (
22424883
)
Response to citalopram treatment (
19846067
)
Schizophrenia (
23212062
)
Subcutaneous adipose tissue (
22589738
)
Total ventricular volume (
21116278
)
Protein-Protein Interactions
12 interactors:
APP
ATXN1
CIITA
JTB
NR1H2
NR1H3
POGZ
RORA
SH3GL2
SMN1
TK1
WDR5
20 interactors:
COPS5
EIF3I
EP300
GFAP
LMO3
LRIF1
MED1
MYOD1
NCOA1
NCOA2
NME1
NME2
NR0B1
NSD1
PNRC1
PNRC2
PROX1
PSMC5
SMARCD3
ZXDC
Entrez ID
79364
6095
HPRD ID
14420
02896
Ensembl ID
ENSG00000070476
ENSG00000069667
Uniprot IDs
Q2QGD7
F1DAL0
P35398
PDB IDs
1N83
1S0X
Enriched GO Terms of Interacting Partners
?
Regulation Of Cholesterol Homeostasis
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Pinocytosis
Intracellular Receptor Signaling Pathway
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Cholesterol Storage
Negative Regulation Of Interferon-gamma-mediated Signaling Pathway
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Steroid Hormone Mediated Signaling Pathway
Positive Regulation Of Cholesterol Efflux
Lipid Homeostasis
Positive Regulation Of Fatty Acid Biosynthetic Process
Positive Regulation Of Lipoprotein Lipase Activity
Positive Regulation Of Triglyceride Biosynthetic Process
Positive Regulation Of Cholesterol Transport
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
RNA Metabolic Process
Hormone-mediated Signaling Pathway
Negative Regulation Of Lipid Storage
Regulation Of Cholesterol Efflux
Regulation Of Triglyceride Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Interferon-gamma-mediated Signaling Pathway
Gene Expression
Regulation Of Response To Interferon-gamma
Negative Regulation Of Lipid Transport
Response To Steroid Hormone
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Macrophage Activation
Transcription Initiation From RNA Polymerase II Promoter
Cellular Response To Steroid Hormone Stimulus
Regulation Of Cellular Ketone Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Endocytosis
Negative Regulation Of Signal Transduction
Positive Regulation Of Fatty Acid Metabolic Process
Regulation Of Fatty Acid Biosynthetic Process
Regulation Of Cholesterol Transport
Triglyceride Homeostasis
Acylglycerol Homeostasis
Regulation Of Triglyceride Metabolic Process
Negative Regulation Of Innate Immune Response
Negative Regulation Of Cytokine-mediated Signaling Pathway
Negative Regulation Of Signaling
Transcription, DNA-templated
RNA Biosynthetic Process
Gene Expression
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Biosynthetic Process
RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Cellular Nitrogen Compound Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Positive Regulation Of Cell Differentiation
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Cellular Process
Cellular Metabolic Process
Limbic System Development
Peptidyl-lysine Modification
Response To Steroid Hormone
Regulation Of Cell Differentiation
Histone Acetylation
Positive Regulation Of Cell Development
Internal Peptidyl-lysine Acetylation
Peptidyl-lysine Acetylation
Positive Regulation Of Metabolic Process
Internal Protein Amino Acid Acetylation
Regulation Of Cell Development
Protein Acetylation
Transcription From RNA Polymerase II Promoter
Negative Regulation Of Gene Expression
Chromatin Modification
Response To Hormone
Positive Regulation Of Epithelial Cell Proliferation
Histone H4 Acetylation
Histone Modification
Regulation Of Neurogenesis
Tagcloud
?
15q21
backcross
cdna
chromosomal
chromosome
clone
fluorescence
hybridization
interspecific
map
mapped
member
mouse
partial
places
pml
promyelocytic
proximity
q22
rara
reciprocal
retinoid
situ
steroid
superfamily
thyroid
translocation
unique
Tagcloud (Difference)
?
15q21
backcross
cdna
chromosomal
chromosome
clone
fluorescence
hybridization
interspecific
map
mapped
member
mouse
partial
places
pml
promyelocytic
proximity
q22
rara
reciprocal
retinoid
situ
steroid
superfamily
thyroid
translocation
unique
Tagcloud (Intersection)
?