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ZXDC and NR1H3
Number of citations of the paper that reports this interaction (PMID
15604093
)
36
Data Source:
BioGRID
(two hybrid, two hybrid)
ZXDC
NR1H3
Gene Name
ZXD family zinc finger C
nuclear receptor subfamily 1, group H, member 3
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cellular_component
Nucleus
Nuclear Chromatin
Nucleus
Nucleoplasm
Receptor Complex
RNA Polymerase II Transcription Factor Complex
Molecular Function
Nucleic Acid Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
LRR Domain Binding
Metal Ion Binding
C2H2 Zinc Finger Domain Binding
DNA Binding
Steroid Hormone Receptor Activity
Transcription Coactivator Activity
Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity
Protein Binding
Zinc Ion Binding
Cholesterol Binding
Sterol Response Element Binding
Sequence-specific DNA Binding
Transcription Regulatory Region DNA Binding
Biological Process
Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Transcription Initiation From RNA Polymerase II Promoter
Gene Expression
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Triglyceride Biosynthetic Process
Positive Regulation Of Receptor Biosynthetic Process
Positive Regulation Of Cholesterol Efflux
Negative Regulation Of Cholesterol Storage
Intracellular Receptor Signaling Pathway
Positive Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Lipid Transport
Positive Regulation Of Cholesterol Transport
Response To Progesterone
Positive Regulation Of Toll-like Receptor 4 Signaling Pathway
Cholesterol Homeostasis
Regulation Of Circadian Rhythm
Negative Regulation Of Macrophage Activation
Apoptotic Cell Clearance
Steroid Hormone Mediated Signaling Pathway
Positive Regulation Of Fatty Acid Biosynthetic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Pinocytosis
Negative Regulation Of Inflammatory Response
Positive Regulation Of Lipoprotein Lipase Activity
Lipid Homeostasis
Sterol Homeostasis
Negative Regulation Of Interferon-gamma-mediated Signaling Pathway
Triglyceride Homeostasis
Cellular Response To Lipopolysaccharide
Negative Regulation Of Pancreatic Juice Secretion
Negative Regulation Of Secretion Of Lysosomal Enzymes
Regulation Of Cholesterol Homeostasis
Positive Regulation Of Cholesterol Homeostasis
Pathways
Drugs
Diseases
GWAS
HDL cholesterol (
19060910
20686565
)
Metabolic syndrome (
22399527
)
Protein-Protein Interactions
12 interactors:
APP
ATXN1
CIITA
JTB
NR1H2
NR1H3
POGZ
RORA
SH3GL2
SMN1
TK1
WDR5
30 interactors:
ACTN1
APP
CEP350
EDF1
EIF3I
FOXO3
ING3
KAT2B
KDM1A
LZTR1
MDFI
MSTO1
NCOA3
NCOA6
NCOR1
NR0B2
NR3C1
NRIP1
PPARA
RARA
RXRA
RXRB
RXRG
SIRT1
SRC
SS18L1
SUV39H1
SYT1
TMEM161A
ZXDC
Entrez ID
79364
10062
HPRD ID
14420
07211
Ensembl ID
ENSG00000070476
ENSG00000025434
Uniprot IDs
Q2QGD7
B4DXU5
F1D8N1
Q13133
PDB IDs
1UHL
3IPQ
3IPS
3IPU
Enriched GO Terms of Interacting Partners
?
Regulation Of Cholesterol Homeostasis
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Pinocytosis
Intracellular Receptor Signaling Pathway
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Cholesterol Storage
Negative Regulation Of Interferon-gamma-mediated Signaling Pathway
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Steroid Hormone Mediated Signaling Pathway
Positive Regulation Of Cholesterol Efflux
Lipid Homeostasis
Positive Regulation Of Fatty Acid Biosynthetic Process
Positive Regulation Of Lipoprotein Lipase Activity
Positive Regulation Of Triglyceride Biosynthetic Process
Positive Regulation Of Cholesterol Transport
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
RNA Metabolic Process
Hormone-mediated Signaling Pathway
Negative Regulation Of Lipid Storage
Regulation Of Cholesterol Efflux
Regulation Of Triglyceride Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Interferon-gamma-mediated Signaling Pathway
Gene Expression
Regulation Of Response To Interferon-gamma
Negative Regulation Of Lipid Transport
Response To Steroid Hormone
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Macrophage Activation
Transcription Initiation From RNA Polymerase II Promoter
Cellular Response To Steroid Hormone Stimulus
Regulation Of Cellular Ketone Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Endocytosis
Negative Regulation Of Signal Transduction
Positive Regulation Of Fatty Acid Metabolic Process
Regulation Of Fatty Acid Biosynthetic Process
Regulation Of Cholesterol Transport
Triglyceride Homeostasis
Acylglycerol Homeostasis
Regulation Of Triglyceride Metabolic Process
Negative Regulation Of Innate Immune Response
Negative Regulation Of Cytokine-mediated Signaling Pathway
Negative Regulation Of Signaling
Intracellular Receptor Signaling Pathway
Positive Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of RNA Metabolic Process
Transcription, DNA-templated
RNA Biosynthetic Process
DNA-templated Transcription, Initiation
Regulation Of Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Gene Expression
Positive Regulation Of Metabolic Process
Gene Expression
RNA Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Cellular Response To Steroid Hormone Stimulus
Regulation Of Metabolic Process
Steroid Hormone Mediated Signaling Pathway
Reproductive Structure Development
Reproductive System Development
Hormone-mediated Signaling Pathway
Intracellular Steroid Hormone Receptor Signaling Pathway
Response To Hormone
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Response To Hormone Stimulus
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Transcription From RNA Polymerase II Promoter
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Developmental Process Involved In Reproduction
Organ Development
Cellular Nitrogen Compound Metabolic Process
Cellular Response To Organic Cyclic Compound
Retinoic Acid Receptor Signaling Pathway
Reproductive Process
Regulation Of Binding
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Tagcloud
?
abca1
abcg5
abcg8
atorvastatin
causal
challenging
chow
excised
fads1
gwas
hfd
hypertensive
list
loci
lpl
madd
nominally
orthologs
overlapped
pcsk9
pltp
qpcr
qtl
responded
spontaneously
stac3
staged
suggestive
timd4
Tagcloud (Difference)
?
abca1
abcg5
abcg8
atorvastatin
causal
challenging
chow
excised
fads1
gwas
hfd
hypertensive
list
loci
lpl
madd
nominally
orthologs
overlapped
pcsk9
pltp
qpcr
qtl
responded
spontaneously
stac3
staged
suggestive
timd4
Tagcloud (Intersection)
?