HNRNPU and YAP1

Number of citations of the paper that reports this interaction (PMID 15096513)
8

Data Source:
HPRD (in vitro, in vivo)

		HNRNPU	YAP1
Gene Name		heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	Yes-associated protein 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cell Surface Membrane Ribonucleoprotein Complex Cytoplasmic Ribonucleoprotein Granule CRD-mediated MRNA Stability Complex Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Membrane Cell Junction
	Molecular Function	Core Promoter Binding DNA Binding RNA Binding Protein Binding ATP Binding Poly(A) RNA Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Regulatory Region DNA Binding Proline-rich Region Binding
	Biological Process	MRNA Splicing, Via Spliceosome Osteoblast Differentiation RNA Processing RNA Splicing Gene Expression Circadian Regulation Of Gene Expression CRD-mediated MRNA Stabilization	Cell Morphogenesis Vasculogenesis Embryonic Heart Tube Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Cell Proliferation Positive Regulation Of Cell Proliferation Gene Expression Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Negative Regulation Of Epithelial Cell Differentiation Notochord Development Somatic Stem Cell Maintenance Hippo Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Organ Growth Paraxial Mesoderm Development Lateral Mesoderm Development Contact Inhibition Cellular Response To Gamma Radiation Regulation Of Stem Cell Proliferation Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Stem Cell Maintenance Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway	PPARA activates gene expression Nuclear signaling by ERBB4 Fatty acid, triacylglycerol, and ketone body metabolism Signaling by Hippo Generic Transcription Pathway Metabolism of lipids and lipoproteins YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Signaling by ERBB4
Drugs
Diseases
GWAS			MRI atrophy measures ( 21116278) Polycystic ovary syndrome ( 22885925) Prostate cancer ( 23535732) Pubertal anthropometrics ( 23449627)
Protein-Protein Interactions		35 interactors: ACTB BTRC CASP3 CD5 CDKN2A CR2 ELL EP300 ERG GAS7 GRIN1 GRIN2D GTF2H1 HNRNPD HNRNPH3 IL7R KAT2B NDN NDRG1 NEDD4 NR3C1 PIN1 POLR2A POU3F4 PRMT1 PRPF40A PTPN11 SMN1 SREK1 STAU1 SYK TCERG1 WBP4 YAP1 ZNF689	28 interactors: ABL1 AKT1 BTRC DENND3 ERBB4 HNRNPU KIF5A LATS1 LATS2 NFE2 RUNX1 RUNX2 RUNX3 SCAMP3 SLC9A3R1 SMAD1 SMAD7 TEAD1 TEAD2 TEAD3 TEAD4 TP53BP2 TP63 TP73 WBP1 WBP2 YWHAG YWHAQ
Entrez ID		3192	10413
HPRD ID		04185	09424
Ensembl ID		ENSG00000153187	ENSG00000137693
Uniprot IDs		Q00839 Q96BA7	K0KVU2 P46937 Q86T74
PDB IDs		1ZRJ	1JMQ 1K5R 1K9Q 1K9R 2LAW 2LAX 2LAY 2LTV 2LTW 3KYS 3MHR
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Developmental Process Gene Expression Regulation Of Cell Cycle Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Viral Process MRNA Processing Multicellular Organismal Development Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process RNA Splicing Positive Regulation Of Viral Transcription Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process System Development MRNA Metabolic Process Positive Regulation Of Gene Expression Viral Process Positive Regulation Of Cellular Metabolic Process Signal Transduction RNA Processing Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated Regulation Of Cellular Process RNA Biosynthetic Process Cellular Response To Stimulus Cellular Nitrogen Compound Metabolic Process Anatomical Structure Morphogenesis Regulation Of Viral Process Transcription From RNA Polymerase II Promoter Regulation Of Viral Transcription Regulation Of T Cell Activation Signaling Transcription Initiation From RNA Polymerase II Promoter Cell Communication Regulation Of Metabolic Process Cellular Metabolic Process N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process	Hippo Signaling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Organ Development Positive Regulation Of Gene Expression Intracellular Signal Transduction Positive Regulation Of Cellular Biosynthetic Process System Development Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signal Transduction Developmental Process Anatomical Structure Development Epithelium Development Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Response To Stimulus Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signaling Regulation Of Metabolic Process Positive Regulation Of Stem Cell Maintenance Negative Regulation Of Phosphorylation Signaling Tissue Development Cell Communication Positive Regulation Of Cell Differentiation Embryo Development Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Transferase Activity Negative Regulation Of Protein Phosphorylation Transcription, DNA-templated Regulation Of Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Anatomical Structure Morphogenesis Apoptotic Signaling Pathway Regulation Of RNA Metabolic Process Cell Differentiation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process Gene Expression Response To Organic Substance DNA-templated Transcription, Initiation
Tagcloud ?		17p13 1q21 1q44 2q23 2q31 agilent annotations asd autism backgrounds cgh cnv cnvs disabilities dissect encephalopathy epileptic exome expand hallux implicates infantile intellectual lissencephaly mbd5 microcephaly pafah1b1 pathogenicity spasms	alarco albicans balan brefeldin bzip caglr1 cai4 cap1 catrr1 caycf1 cdr1 cdr2 cerulenin cjd21 diamide facilitator fcz flr1 fr2 hyperactive hyperresistant mainville mdr1 nitroquinoline phenanthroline raymond reintroduction talibi transformants
Tagcloud (Difference) ?		17p13 1q21 1q44 2q23 2q31 agilent annotations asd autism backgrounds cgh cnv cnvs disabilities dissect encephalopathy epileptic exome expand hallux implicates infantile intellectual lissencephaly mbd5 microcephaly pafah1b1 pathogenicity spasms	alarco albicans balan brefeldin bzip caglr1 cai4 cap1 catrr1 caycf1 cdr1 cdr2 cerulenin cjd21 diamide facilitator fcz flr1 fr2 hyperactive hyperresistant mainville mdr1 nitroquinoline phenanthroline raymond reintroduction talibi transformants
Tagcloud (Intersection) ?