HNRNPU and GTF2H1

Number of citations of the paper that reports this interaction (PubMedID 10490622)
57

Data Source:
HPRD (in vivo)

		HNRNPU	GTF2H1
Description		heterogeneous nuclear ribonucleoprotein U	general transcription factor IIH subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleus Nucleoplasm Spliceosomal Complex Chromosome Telomerase Holoenzyme Complex Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Cell Surface Membrane Nuclear Matrix Nuclear Speck Dendrite Midbody Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule CRD-mediated MRNA Stability Complex Catalytic Step 2 Spliceosome Mitotic Spindle RNA Polymerase II Transcription Regulator Complex Inactive Sex Chromosome Mitotic Spindle Midzone Mitotic Spindle Microtubule Ribonucleoprotein Complex	Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIIH Holo Complex
	Molecular Function	Nucleotide Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding TFIIH-class Transcription Factor Complex Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Corepressor Activity RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding MRNA 3'-UTR Binding Actin Binding Protein Binding ATP Binding Poly(A) Binding SnRNA Binding Poly(C) RNA Binding Chromatin DNA Binding Poly(G) Binding PiRNA Binding Pre-mRNA Binding Identical Protein Binding Ribonucleoprotein Complex Binding Sequence-specific DNA Binding Protein-containing Complex Binding Telomerase RNA Binding RNA Polymerase II C-terminal Domain Binding LncRNA Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	Chromatin Binding Protein Binding Nuclear Thyroid Hormone Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Osteoblast Differentiation Chromatin Organization RNA Processing MRNA Processing Regulation Of Mitotic Cell Cycle RNA Splicing Dosage Compensation By Inactivation Of X Chromosome Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Cell Differentiation Erythrocyte Differentiation Regulatory NcRNA-mediated Heterochromatin Formation Negative Regulation Of Telomere Maintenance Via Telomerase Circadian Regulation Of Gene Expression Negative Regulation Of Kinase Activity Negative Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II MRNA Stabilization Rhythmic Process Cell Division Maintenance Of Protein Location In Nucleus Cardiac Muscle Cell Development Random Inactivation Of X Chromosome CRD-mediated MRNA Stabilization Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Brown Fat Cell Differentiation Dendritic Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Mitotic Spindle Assembly Regulation Of Chromatin Organization Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Protein Localization To Spindle Microtubule RNA Localization To Chromatin Cellular Response To Leukemia Inhibitory Factor Adaptive Thermogenesis Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Stem Cell Differentiation Positive Regulation Of Cytoplasmic Translation	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Repair Nucleotide-excision Repair DNA-templated Transcription Transcription By RNA Polymerase I Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter DNA Damage Response Hormone-mediated Signaling Pathway Positive Regulation Of DNA-templated Transcription
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases
GWAS			Amyloid A serum levels ( 21124955) Pancreatic cancer ( 23180869) Serum metabolite levels ( 23093944 33031748) Survival in pancreatic cancer ( 28470677) Systemic lupus erythematosus ( 33272962)
Interacting Genes		42 interacting genes: ACTB BTRC CASP3 CD5 CDKN2A CEBPA CR2 DUX4 ELL EP300 ERG GRIN1 GRIN2D GTF2H1 HMGB1 HNRNPH3 HSPB1 IL7R KAT2B LINC00624 NDN NDRG1 NEDD4 NR3C1 NRON PIN1 PLK1 POU3F4 PRMT1 PRPF40A PTPN11 RBPMS2 SMN1 SREK1 STAU1 SUMO2 SYK TCERG1 UBE2I WBP4 YAP1 ZNF689	46 interacting genes: ACTN1 AGTRAP AR ATF7IP BRPF1 CCNH CCSER2 CDK7 E2F1 EAF1 ERCC2 ERCC3 ERCC4 ERCC5 ESR1 FHL2 FUBP1 GTF2E1 GTF2E2 GTF2H2 HNF4A HNRNPU HOXC11 JDP2 KIF13A KPNA3 MCM2 MMS19 MNAT1 OGT PIK3R1 PLCG1 POU2AF1 PSMC2 RAD23A REEP5 RXRB TNIP1 TP53 TRIOBP TXNRD2 UBC USHBP1 XPA XPC ZSCAN1
Entrez ID		3192	2965
HPRD ID		04185	01807
Ensembl ID		ENSG00000153187	ENSG00000110768
Uniprot IDs		Q00839 Q96BA7	A0A384MTQ8 P32780
PDB IDs			1PFJ 2DII 2RNR 2RUK 2RVB 5GOW 5XV8 6NMI 6O9L 6O9M 7AD8 7BUL 7DTI 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVW 7NVX 7NVY 7NVZ 7NW0 8BVW 8BYQ 8EBS 8EBT 8EBU 8EBV 8EBW 8EBX 8EBY 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS
Enriched GO Terms of Interacting Partners?		Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Nucleus Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Intracellular Signal Transduction Postsynaptic Cytosol Developmental Process RNA Binding Protein-containing Complex Cellular Response To Stress Regulation Of Cell Activation Positive Regulation Of T Cell Activation Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Positive Regulation Of Cell Activation Negative Regulation Of Immune System Process Positive Regulation Of Leukocyte Cell-cell Adhesion Macromolecule Metabolic Process Cellular Response To Oxygen-containing Compound Neurotrophin TRK Receptor Signaling Pathway Regulation Of T Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Hemopoiesis Signal Transduction Negative Regulation Of Metabolic Process Response To Amino Acid	Nucleotide-excision Repair Transcription Factor TFIIH Holo Complex Transcription Factor TFIIH Core Complex Transcription Initiation At RNA Polymerase II Promoter DNA-templated Transcription Nucleoplasm Nucleic Acid Metabolic Process DNA-templated Transcription Initiation CAK-ERCC2 Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Response To UV Nucleus Nucleobase-containing Compound Biosynthetic Process Damaged DNA Binding DNA Repair DNA Damage Response Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Factor TFIIK Complex Single-stranded DNA Binding DNA Binding UV Protection Transcription Factor TFIID Complex DNA Metabolic Process RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Response To Light Stimulus Regulation Of Macromolecule Metabolic Process Nucleotide-excision Repair Complex Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Response To Radiation Sequence-specific Double-stranded DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II General Transcription Initiation Factor Activity Transcription-coupled Nucleotide-excision Repair
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