HNRNPU and NRON

Number of citations: 47 (PubMedID 37382239)
Data Source: BioGRID (unspecified method)

		HNRNPU	NRON
Name		heterogeneous nuclear ribonucleoprotein U	non-coding repressor of NFAT
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleus Nucleoplasm Spliceosomal Complex Chromosome Telomerase Holoenzyme Complex Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Cell Surface Membrane Nuclear Matrix Nuclear Speck Dendrite Midbody Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule CRD-mediated MRNA Stability Complex Catalytic Step 2 Spliceosome Mitotic Spindle RNA Polymerase II Transcription Regulator Complex Inactive Sex Chromosome Mitotic Spindle Midzone Mitotic Spindle Microtubule Ribonucleoprotein Complex	None
	Molecular Function	Nucleotide Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding TFIIH-class Transcription Factor Complex Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Corepressor Activity RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding MRNA 3'-UTR Binding Actin Binding Protein Binding ATP Binding Poly(A) Binding SnRNA Binding Poly(C) RNA Binding Chromatin DNA Binding Poly(G) Binding PiRNA Binding Pre-mRNA Binding Identical Protein Binding Ribonucleoprotein Complex Binding Sequence-specific DNA Binding Protein-containing Complex Binding Telomerase RNA Binding RNA Polymerase II C-terminal Domain Binding LncRNA Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	None
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Osteoblast Differentiation Chromatin Organization RNA Processing MRNA Processing Regulation Of Mitotic Cell Cycle RNA Splicing Dosage Compensation By Inactivation Of X Chromosome Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Cell Differentiation Erythrocyte Differentiation Regulatory NcRNA-mediated Heterochromatin Formation Negative Regulation Of Telomere Maintenance Via Telomerase Circadian Regulation Of Gene Expression Negative Regulation Of Kinase Activity Negative Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II MRNA Stabilization Rhythmic Process Cell Division Maintenance Of Protein Location In Nucleus Cardiac Muscle Cell Development Random Inactivation Of X Chromosome CRD-mediated MRNA Stabilization Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Brown Fat Cell Differentiation Dendritic Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Mitotic Spindle Assembly Regulation Of Chromatin Organization Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Protein Localization To Spindle Microtubule RNA Localization To Chromatin Cellular Response To Leukemia Inhibitory Factor Adaptive Thermogenesis Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Stem Cell Differentiation Positive Regulation Of Cytoplasmic Translation	None
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	None
GWAS		No GWAS studies recorded	Bipolar disorder ( 31043756 ) Eyebrow thickness ( 26926045 ) Malaria ( 31844061 )
Interacting Genes		42 interacting genes: ACTB BTRC CASP3 CD5 CDKN2A CEBPA CR2 DUX4 ELL EP300 ERG GRIN1 GRIN2D GTF2H1 HMGB1 HNRNPH3 HSPB1 IL7R KAT2B LINC00624 NDN NDRG1 NEDD4 NR3C1 NRON PIN1 PLK1 POU3F4 PRMT1 PRPF40A PTPN11 RBPMS2 SMN1 SREK1 STAU1 SUMO2 SYK TCERG1 UBE2I WBP4 YAP1 ZNF689	8 interacting genes: HNRNPU KHSRP MATR3 MDM2 MDM4 NFATC2 NUMB TP53
Entrez ID		3192	641373
HPRD ID		04185	Not available
Ensembl ID		ENSG00000153187	Not available
Uniprot IDs		Q00839 Q96BA7	Not available
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Nucleus Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Intracellular Signal Transduction Postsynaptic Cytosol Developmental Process RNA Binding Protein-containing Complex Cellular Response To Stress Regulation Of Cell Activation Positive Regulation Of T Cell Activation Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Positive Regulation Of Cell Activation Negative Regulation Of Immune System Process Positive Regulation Of Leukocyte Cell-cell Adhesion Macromolecule Metabolic Process Cellular Response To Oxygen-containing Compound Neurotrophin TRK Receptor Signaling Pathway Regulation Of T Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Hemopoiesis Signal Transduction Negative Regulation Of Metabolic Process Response To Amino Acid	Heart Valve Development Ventricular Septum Development Cellular Response To Actinomycin D Response To Actinomycin D Cardiac Septum Development DNA Damage Response, Signal Transduction By P53 Class Mediator Cellular Response To UV-C Transcription Repressor Complex Atrial Septum Development Cellular Response To Antibiotic Signal Transduction By P53 Class Mediator Response To UV-C Negative Regulation Of Transcription By RNA Polymerase II Nuclear Matrix Cellular Response To Hypoxia Negative Regulation Of Telomere Maintenance Via Telomerase Cellular Response To Decreased Oxygen Levels Endocardial Cushion Morphogenesis Signal Transduction In Response To DNA Damage Atrioventricular Valve Morphogenesis Cellular Response To Oxygen Levels Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Disordered Domain Specific Binding Cellular Response To Gamma Radiation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process 14-3-3 Protein Binding Regulation Of ATP-dependent Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Antibiotic Negative Regulation Of Telomere Maintenance Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Ribonucleoprotein Complex Binding Negative Regulation Of RNA Metabolic Process Regulation Of Telomere Maintenance Via Telomerase Regulation Of Transcription By RNA Polymerase II Neuroblast Proliferation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Biological Quality Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell Differentiation Response To Xenobiotic Stimulus DNA Damage Response Response To Hypoxia Response To Gamma Radiation