HNRNPU and GRIN2D

Number of citations of the paper that reports this interaction (PubMedID 10862698)
0

Data Source:
HPRD (in vivo)

		HNRNPU	GRIN2D
Description		heterogeneous nuclear ribonucleoprotein U	glutamate ionotropic receptor NMDA type subunit 2D
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleus Nucleoplasm Spliceosomal Complex Chromosome Telomerase Holoenzyme Complex Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Cell Surface Membrane Nuclear Matrix Nuclear Speck Dendrite Midbody Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule CRD-mediated MRNA Stability Complex Catalytic Step 2 Spliceosome Mitotic Spindle RNA Polymerase II Transcription Regulator Complex Inactive Sex Chromosome Mitotic Spindle Midzone Mitotic Spindle Microtubule Ribonucleoprotein Complex	Endoplasmic Reticulum Membrane Plasma Membrane Membrane NMDA Selective Glutamate Receptor Complex Presynaptic Membrane Synapse Postsynaptic Membrane Presynaptic Active Zone Membrane Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Nucleotide Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding TFIIH-class Transcription Factor Complex Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Corepressor Activity RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding MRNA 3'-UTR Binding Actin Binding Protein Binding ATP Binding Poly(A) Binding SnRNA Binding Poly(C) RNA Binding Chromatin DNA Binding Poly(G) Binding PiRNA Binding Pre-mRNA Binding Identical Protein Binding Ribonucleoprotein Complex Binding Sequence-specific DNA Binding Protein-containing Complex Binding Telomerase RNA Binding RNA Polymerase II C-terminal Domain Binding LncRNA Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	Glutamate-gated Receptor Activity NMDA Glutamate Receptor Activity Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Protein Binding Ligand-gated Monoatomic Ion Channel Activity Glutamate Binding Voltage-gated Monoatomic Cation Channel Activity Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Osteoblast Differentiation Chromatin Organization RNA Processing MRNA Processing Regulation Of Mitotic Cell Cycle RNA Splicing Dosage Compensation By Inactivation Of X Chromosome Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Cell Differentiation Erythrocyte Differentiation Regulatory NcRNA-mediated Heterochromatin Formation Negative Regulation Of Telomere Maintenance Via Telomerase Circadian Regulation Of Gene Expression Negative Regulation Of Kinase Activity Negative Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II MRNA Stabilization Rhythmic Process Cell Division Maintenance Of Protein Location In Nucleus Cardiac Muscle Cell Development Random Inactivation Of X Chromosome CRD-mediated MRNA Stabilization Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Brown Fat Cell Differentiation Dendritic Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Mitotic Spindle Assembly Regulation Of Chromatin Organization Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Protein Localization To Spindle Microtubule RNA Localization To Chromatin Cellular Response To Leukemia Inhibitory Factor Adaptive Thermogenesis Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Stem Cell Differentiation Positive Regulation Of Cytoplasmic Translation	Startle Response Monoatomic Ion Transport Brain Development Adult Locomotory Behavior Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Regulation Of Sensory Perception Of Pain Positive Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Calcium Ion Transmembrane Import Into Cytosol Monoatomic Cation Transmembrane Transport Excitatory Chemical Synaptic Transmission Regulation Of Presynaptic Membrane Potential Regulation Of Monoatomic Cation Transmembrane Transport Cellular Response To L-glutamate Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs			Glutamic acid Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Dextropropoxyphene Acamprosate Donepezil Guaifenesin Memantine Orphenadrine Phenobarbital Aripiprazole Tenocyclidine Prasterone Milnacipran Acetylcysteine Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)
Diseases
GWAS
Interacting Genes		42 interacting genes: ACTB BTRC CASP3 CD5 CDKN2A CEBPA CR2 DUX4 ELL EP300 ERG GRIN1 GRIN2D GTF2H1 HMGB1 HNRNPH3 HSPB1 IL7R KAT2B LINC00624 NDN NDRG1 NEDD4 NR3C1 NRON PIN1 PLK1 POU3F4 PRMT1 PRPF40A PTPN11 RBPMS2 SMN1 SREK1 STAU1 SUMO2 SYK TCERG1 UBE2I WBP4 YAP1 ZNF689	33 interacting genes: ABL1 CDH2 CIT CLTC CTNNB1 DLG2 DLG4 DLGAP4 DNM1 DUSP4 FUS GRIN1 HNRNPU HRAS HSPA1A IL16 INA MAP2 MAP2K2 NANOS1 NF1 PATJ PPP2R1A PPP2R2A PRKCB PRKCE PRKCG RAP2A RPS6KA3 SPTAN1 SYNGAP1 TJP1 TRAF3
Entrez ID		3192	2906
HPRD ID		04185	04095
Ensembl ID		ENSG00000153187	ENSG00000105464
Uniprot IDs		Q00839 Q96BA7	O15399 Q59G17
PDB IDs			7YFF 7YFL 7YFM 7YFO 7YFR 8E96 8Y1V 9D37 9D38 9D39 9D3A 9D3B 9D3C
Enriched GO Terms of Interacting Partners?		Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Nucleus Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Intracellular Signal Transduction Postsynaptic Cytosol Developmental Process RNA Binding Protein-containing Complex Cellular Response To Stress Regulation Of Cell Activation Positive Regulation Of T Cell Activation Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Positive Regulation Of Cell Activation Negative Regulation Of Immune System Process Positive Regulation Of Leukocyte Cell-cell Adhesion Macromolecule Metabolic Process Cellular Response To Oxygen-containing Compound Neurotrophin TRK Receptor Signaling Pathway Regulation Of T Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Hemopoiesis Signal Transduction Negative Regulation Of Metabolic Process Response To Amino Acid	Regulation Of Cellular Component Organization Modulation Of Chemical Synaptic Transmission Synapse Protein Kinase Binding Regulation Of Cytoskeleton Organization Glutamatergic Synapse Regulation Of Neuronal Synaptic Plasticity Regulation Of Synaptic Plasticity Regulation Of Organelle Organization Regulation Of Biological Quality Regulation Of Long-term Neuronal Synaptic Plasticity Cytosol Plasma Membrane Cytoplasm Regulation Of MAPK Cascade Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Post-translational Protein Modification Regulation Of Intracellular Signal Transduction Chemical Synaptic Transmission Neuron Apoptotic Process Dendrite Cell Junction Receptor Clustering Trans-synaptic Signaling Neuron Projection Regulation Of Anatomical Structure Morphogenesis Regulation Of Transport Synaptic Signaling Response To Morphine Diacylglycerol-dependent Serine/threonine Kinase Activity Perinuclear Region Of Cytoplasm MAPK Cascade Regulation Of Cellular Localization Schwann Cell Development Synaptic Membrane Regulation Of Neuron Apoptotic Process Positive Regulation Of Synaptic Transmission Postsynaptic Density Protein Serine/threonine Kinase Activity Regulation Of Signal Transduction Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Intracellular Protein Localization Learning Or Memory Learning Negative Regulation Of Protein Ubiquitination Regulation Of Developmental Process Regulation Of Microtubule Cytoskeleton Organization Disordered Domain Specific Binding
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