PDZK1 and SLC22A12

Number of citations of the paper that reports this interaction (PubMedID 14531806)
0

Data Source:
HPRD (two hybrid, in vitro)

		PDZK1	SLC22A12
Description		PDZ domain containing 1	solute carrier family 22 member 12
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GO Annotations	Cellular Component	Plasma Membrane Brush Border Membrane Apical Plasma Membrane Brush Border Membrane Microvillus Membrane Extracellular Exosome	Plasma Membrane Membrane Apical Plasma Membrane Brush Border Membrane Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Scavenger Receptor Binding Protein Binding PDZ Domain Binding Protein-membrane Adaptor Activity Protein-containing Complex Binding Transporter Activator Activity	Urate Transmembrane Transporter Activity Transmembrane Transporter Activity PDZ Domain Binding
	Biological Process	Regulation Of Monoatomic Anion Transport Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Carnitine Transmembrane Transport Positive Regulation Of Protein Localization To Membrane Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane	Monoatomic Ion Transport Response To Xenobiotic Stimulus Organic Anion Transport Urate Transport Cellular Homeostasis Cellular Response To Insulin Stimulus Urate Metabolic Process Transmembrane Transport Renal Urate Salt Excretion
Pathways			Organic anion transport by SLC22 transporters Defective SLC22A12 causes renal hypouricemia 1 (RHUC1)
Drugs			Sulfinpyrazone Lesinurad
Diseases			Renal hypouricemia (RHUC)
GWAS		Contrast sensitivity ( 24152035) Gout ( 32238385 33832965) Serum uric acid levels ( 30993211) Urate levels ( 20884846 23263486 31578528 31985003) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 19503597)	Gout ( 27899376) Gout (combined type) ( 32238385) Hyperuricemia ( 29124443) Renal function-related traits (urate) ( 22797727) Renal overload gout ( 27899376) Renal underexcretion gout ( 27899376) Serum uric acid levels ( 32514006 30993211 29124443 26902266) Systemic lupus erythematosus ( 26606652) Urate levels ( 23263486 21768215 31578528 31985003 20139978) Urate levels in lean individuals ( 25811787) Urate levels in obese individuals ( 25811787) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 19503597)
Interacting Genes		30 interacting genes: ABCA1 ABCC2 ABCC4 ACE2 AKAP10 APP CFTR CLCN3 CRHR1 FARP2 GFAP NHERF2 PDZK1IP1 PEX5 RPS6KA1 SCARB1 SLC13A1 SLC15A2 SLC17A1 SLC22A11 SLC22A12 SLC22A4 SLC22A5 SLC26A6 SLC34A1 SLC9A3 SLCO1A2 SLK SSTR5 UBE2I	1 interacting genes: PDZK1
Entrez ID		5174	116085
HPRD ID		04829	06160
Ensembl ID		ENSG00000174827	ENSG00000197891
Uniprot IDs		B2R7S7 Q5T2W1	B3KP53 Q96S37
PDB IDs		2EEI 2EEJ 2VSP 3TMH 4Q2P 6EZI	8WJG 8WJQ 9B1F 9B1G 9B1H 9B1I 9B1J 9B1K 9B1L 9B1M 9B1N 9B1O 9IRW 9IRX 9IRY 9JDV 9JDY 9JDZ 9JE0 9JE1
Enriched GO Terms of Interacting Partners?		Apical Plasma Membrane Transmembrane Transport PDZ Domain Binding Monoatomic Ion Transport Organic Anion Transport Transmembrane Transporter Activity Brush Border Membrane Plasma Membrane Inorganic Anion Transport Organic Hydroxy Compound Transport Carboxylic Acid Transport Organic Acid Transport Xenobiotic Transport Symporter Activity Inorganic Anion Transmembrane Transport Monoatomic Anion Transmembrane Transport Monoatomic Anion Transport Membrane Urate Transport Monoatomic Ion Transmembrane Transport Urate Metabolic Process ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Sodium Ion Transport ABC-type Transporter Activity Lipid Transport Cell Surface Xenobiotic Export From Cell Monocarboxylic Acid Transport Apolipoprotein Binding Export Across Plasma Membrane Organic Anion Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Basal Plasma Membrane Import Across Plasma Membrane Vascular Process In Circulatory System Bile Acid And Bile Salt Transport Xenobiotic Transmembrane Transporter Activity Amino-acid Betaine Transmembrane Transporter Activity Chemical Homeostasis Transport Across Blood-brain Barrier Regulation Of Intracellular PH Organic Cation Transport Regulation Of Cellular PH Circulatory System Process Inorganic Ion Transmembrane Transport Carnitine Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Antiporter Activity Peptide Transport Regulation Of PH	Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Regulation Of Monoatomic Anion Transport Xenobiotic Export From Cell Scavenger Receptor Binding Carnitine Transmembrane Transport Amino-acid Betaine Transport Carnitine Transport Quaternary Ammonium Group Transport Transporter Activator Activity Microvillus Membrane Positive Regulation Of Protein Targeting To Membrane Regulation Of Protein Targeting To Membrane Protein-membrane Adaptor Activity Xenobiotic Transport Brush Border Membrane Export Across Plasma Membrane Brush Border Organic Cation Transport Positive Regulation Of Protein Localization To Membrane PDZ Domain Binding Regulation Of Protein Localization To Membrane Protein Localization To Plasma Membrane Protein Localization To Cell Periphery Protein Localization To Membrane Positive Regulation Of Establishment Of Protein Localization Protein-containing Complex Binding Apical Plasma Membrane Signaling Receptor Binding Regulation Of Monoatomic Ion Transport Positive Regulation Of Protein Localization
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