PDZK1 and SLC22A12

Number of citations of the paper that reports this interaction (PMID 14531806)
31

Data Source:
HPRD (in vitro, two hybrid)

		PDZK1	SLC22A12
Gene Name		PDZ domain containing 1	solute carrier family 22 (organic anion/urate transporter), member 12
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Apical Plasma Membrane Brush Border Membrane Microvillus Membrane Membrane Raft Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Brush Border Membrane Extracellular Vesicular Exosome
	Molecular Function	Scavenger Receptor Binding Transporter Activity Protein Binding PDZ Domain Binding Protein Complex Binding	Urate Transmembrane Transporter Activity PDZ Domain Binding
	Biological Process	Transport Cell Proliferation Carnitine Transport Drug Transport Positive Regulation Of Ion Transmembrane Transport Regulation Of Anion Transport Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane	Urate Transport Organic Acid Transport Cellular Homeostasis Response To Drug Urate Metabolic Process Transmembrane Transport
Pathways			Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds Organic anion transport Organic cation/anion/zwitterion transport SLC-mediated transmembrane transport
Drugs
Diseases
GWAS		Urate levels ( 20884846 23263486) Uric acid levels ( 19503597)	Renal function-related traits (urea) ( 22797727) Urate levels ( 21768215 20139978 23263486) Uric acid levels ( 19503597)
Protein-Protein Interactions		27 interactors: ABCA1 ABCC2 ABCC4 AKAP10 APP CFTR CLCN3 FARP2 GFAP PDZK1IP1 PEX5 SCARB1 SLC15A2 SLC17A1 SLC22A11 SLC22A12 SLC22A4 SLC22A5 SLC26A6 SLC34A3 SLC9A3 SLC9A3R1 SLC9A3R2 SLCO1A2 SLK SSTR5 UBE2I	1 interactors: PDZK1
Entrez ID		5174	116085
HPRD ID		04829	06160
Ensembl ID		ENSG00000174827	ENSG00000197891
Uniprot IDs		Q5T2W1	B3KP53 B5ME56 G3XAN7 Q96S37
PDB IDs		2EEI 2EEJ 2VSP 3TMH
Enriched GO Terms of Interacting Partners?		Anion Transport Transmembrane Transport Anion Transmembrane Transport Organic Anion Transport Ion Transport Ion Transmembrane Transport Homeostatic Process Chemical Homeostasis Ion Homeostasis Monocarboxylic Acid Transport Inorganic Anion Transport Transport Organic Acid Transport Anion Homeostasis Urate Metabolic Process Sodium Ion Transport Cellular Ion Homeostasis Cellular Homeostasis Lipid Transport Regulation Of PH Carboxylic Acid Transport Response To Drug Cellular Chemical Homeostasis Lipid Localization Monovalent Inorganic Cation Transport Antibiotic Transport Steroid Metabolic Process Cholesterol Metabolic Process Regulation Of Intracellular PH Regulation Of Cellular PH Sterol Metabolic Process Drug Transport Cellular Phosphate Ion Homeostasis Intracellular PH Elevation Cell Maturation Sodium-dependent Phosphate Transport Transepithelial Chloride Transport Neuron Remodeling Secretion Cholesterol Transport Sterol Transport Oligopeptide Transport Carnitine Transmembrane Transport Carnitine Transport Small Molecule Metabolic Process Transepithelial Transport Phosphate Ion Homeostasis Phosphate Ion Transmembrane Transport Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Peptide Transport	Carnitine Transport Quaternary Ammonium Group Transport Positive Regulation Of Protein Targeting To Membrane Drug Transport Ammonium Transport Positive Regulation Of Ion Transmembrane Transport Establishment Of Protein Localization To Plasma Membrane Monocarboxylic Acid Transport Regulation Of Anion Transport Protein Localization To Plasma Membrane Positive Regulation Of Intracellular Protein Transport Positive Regulation Of Ion Transport Plasma Membrane Organization Establishment Of Protein Localization To Membrane Positive Regulation Of Intracellular Transport Regulation Of Intracellular Protein Transport Inorganic Anion Transport Carboxylic Acid Transport Organic Acid Transport Positive Regulation Of Protein Transport Protein Localization To Membrane Regulation Of Ion Transmembrane Transport Endomembrane System Organization Regulation Of Intracellular Transport Organic Anion Transport Response To Drug Regulation Of Protein Transport Regulation Of Ion Transport Monovalent Inorganic Cation Transport Anion Transport Regulation Of Establishment Of Protein Localization Cell Proliferation Positive Regulation Of Transport
Tagcloud ?		across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pgr premenopausal progesterone rankl responsiveness rhythm runx1 serpina3 serpina5 tff1 tumours varies w1 w2 w3 windows	causative collaborative determinant diminishes dysfunctional exon expand glut9 hypouricemia institutional japan japanese micc missense mutational pathogenic r198c r380w rhuc rhuc1 rhuc2 sua topology transporter urat1 urate uric urolithiasis
Tagcloud (Difference) ?		across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pgr premenopausal progesterone rankl responsiveness rhythm runx1 serpina3 serpina5 tff1 tumours varies w1 w2 w3 windows	causative collaborative determinant diminishes dysfunctional exon expand glut9 hypouricemia institutional japan japanese micc missense mutational pathogenic r198c r380w rhuc rhuc1 rhuc2 sua topology transporter urat1 urate uric urolithiasis
Tagcloud (Intersection) ?