PDZK1 and FARP2

Number of citations of the paper that reports this interaction (PMID 14531806)
31

Data Source:
BioGRID (two hybrid, pull down)

		PDZK1	FARP2
Gene Name		PDZ domain containing 1	FERM, RhoGEF and pleckstrin domain protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Apical Plasma Membrane Brush Border Membrane Microvillus Membrane Membrane Raft Extracellular Vesicular Exosome	Cytoplasm Cytosol Cytoskeleton Extrinsic Component Of Membrane
	Molecular Function	Scavenger Receptor Binding Transporter Activity Protein Binding PDZ Domain Binding Protein Complex Binding	Rho Guanyl-nucleotide Exchange Factor Activity Cytoskeletal Protein Binding Rac Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Transport Cell Proliferation Carnitine Transport Drug Transport Positive Regulation Of Ion Transmembrane Transport Regulation Of Anion Transport Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane	Cell Adhesion Axon Guidance Neuron Remodeling Rac Protein Signal Transduction Osteoclast Differentiation Actin Cytoskeleton Reorganization Positive Regulation Of Rac GTPase Activity Regulation Of Integrin Activation Semaphorin-plexin Signaling Pathway Podosome Assembly
Pathways			Axon guidance Semaphorin interactions SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Drugs
Diseases
GWAS		Urate levels ( 20884846 23263486) Uric acid levels ( 19503597)	Chronic lymphocytic leukemia ( 20062064) Prostate cancer ( 23535732)
Protein-Protein Interactions		27 interactors: ABCA1 ABCC2 ABCC4 AKAP10 APP CFTR CLCN3 FARP2 GFAP PDZK1IP1 PEX5 SCARB1 SLC15A2 SLC17A1 SLC22A11 SLC22A12 SLC22A4 SLC22A5 SLC26A6 SLC34A3 SLC9A3 SLC9A3R1 SLC9A3R2 SLCO1A2 SLK SSTR5 UBE2I	4 interactors: PDZK1 SRC UBE2G2 YWHAG
Entrez ID		5174	9855
HPRD ID		04829	16885
Ensembl ID		ENSG00000174827	ENSG00000006607
Uniprot IDs		Q5T2W1	O94887
PDB IDs		2EEI 2EEJ 2VSP 3TMH
Enriched GO Terms of Interacting Partners?		Anion Transport Transmembrane Transport Anion Transmembrane Transport Organic Anion Transport Ion Transport Ion Transmembrane Transport Homeostatic Process Chemical Homeostasis Ion Homeostasis Monocarboxylic Acid Transport Inorganic Anion Transport Transport Organic Acid Transport Anion Homeostasis Urate Metabolic Process Sodium Ion Transport Cellular Ion Homeostasis Cellular Homeostasis Lipid Transport Regulation Of PH Carboxylic Acid Transport Response To Drug Cellular Chemical Homeostasis Lipid Localization Monovalent Inorganic Cation Transport Antibiotic Transport Steroid Metabolic Process Cholesterol Metabolic Process Regulation Of Intracellular PH Regulation Of Cellular PH Sterol Metabolic Process Drug Transport Cellular Phosphate Ion Homeostasis Intracellular PH Elevation Cell Maturation Sodium-dependent Phosphate Transport Transepithelial Chloride Transport Neuron Remodeling Secretion Cholesterol Transport Sterol Transport Oligopeptide Transport Carnitine Transmembrane Transport Carnitine Transport Small Molecule Metabolic Process Transepithelial Transport Phosphate Ion Homeostasis Phosphate Ion Transmembrane Transport Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Peptide Transport	Regulation Of Intracellular Transport Regulation Of Establishment Of Protein Localization Positive Regulation Of Transport Regulation Of Protein Localization Membrane Organization Cellular Response To Progesterone Stimulus Regulation Of Cellular Localization Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Cellular Response To Insulin Stimulus Positive Regulation Of Intracellular Transport Positive Regulation Of Integrin Activation Negative Regulation Of Mitochondrial Depolarization Positive Regulation Of Podosome Assembly Response To Insulin Negative Regulation Of Protein Homooligomerization Progesterone Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Regulation Of Podosome Assembly Cellular Response To Peptide Positive Regulation Of Protein Transport Regulation Of Caveolin-mediated Endocytosis Osteoclast Development Negative Regulation Of Protein Oligomerization Positive Regulation Of Organelle Organization Regulation Of Integrin Activation Carnitine Transport Regulation Of Early Endosome To Late Endosome Transport Regulation Of Cellular Component Organization Transcytosis Response To Peptide Hormone Cellular Response To Organonitrogen Compound Signal Complex Assembly Stress Fiber Assembly Response To Peptide Negative Regulation Of Anoikis Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Autophosphorylation Response To Drug Uterus Development Intracellular Estrogen Receptor Signaling Pathway Regulation Of Anoikis Response To Acidic PH Quaternary Ammonium Group Transport Regulation Of Mitochondrial Depolarization Positive Regulation Of DNA Biosynthetic Process Negative Regulation Of Focal Adhesion Assembly Cellular Response To Platelet-derived Growth Factor Stimulus Cellular Response To Hormone Stimulus Positive Regulation Of Apoptotic Process Response To Platelet-derived Growth Factor
Tagcloud ?		across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pgr premenopausal progesterone rankl responsiveness rhythm runx1 serpina3 serpina5 tff1 tumours varies w1 w2 w3 windows
Tagcloud (Difference) ?		across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pgr premenopausal progesterone rankl responsiveness rhythm runx1 serpina3 serpina5 tff1 tumours varies w1 w2 w3 windows
Tagcloud (Intersection) ?