PDZK1 and FARP2

Number of citations of the paper that reports this interaction (PubMedID 14531806)
0

Data Source:
BioGRID (two hybrid, pull down)

		PDZK1	FARP2
Description		PDZ domain containing 1	FERM, ARH/RhoGEF and pleckstrin domain protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Brush Border Membrane Apical Plasma Membrane Brush Border Membrane Microvillus Membrane Extracellular Exosome	Cytoplasm Cytosol
	Molecular Function	Signaling Receptor Binding Scavenger Receptor Binding Protein Binding PDZ Domain Binding Protein-membrane Adaptor Activity Protein-containing Complex Binding Transporter Activator Activity	Guanyl-nucleotide Exchange Factor Activity Cytoskeletal Protein Binding
	Biological Process	Regulation Of Monoatomic Anion Transport Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Carnitine Transmembrane Transport Positive Regulation Of Protein Localization To Membrane Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane	Cell Adhesion Signal Transduction Neuron Remodeling Rac Protein Signal Transduction Hair Cycle Process Actin Cytoskeleton Organization Osteoclast Differentiation Regulation Of Integrin Activation Cell Development Semaphorin-plexin Signaling Pathway Podosome Assembly
Pathways			SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion RAC1 GTPase cycle
Drugs
Diseases
GWAS		Contrast sensitivity ( 24152035) Gout ( 32238385 33832965) Serum uric acid levels ( 30993211) Urate levels ( 20884846 23263486 31578528 31985003) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 19503597)	Body size at age 10 ( 32376654) Cerebrospinal fluid immune biomarker levels ( 32066700) Chronic lymphocytic leukemia ( 23770605 28165464) Copper levels ( 26025379) Disability (impaired activities of daily living) ( 31707593) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) Neutrophil percentage of granulocytes ( 27863252) Prostate cancer ( 23535732) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Triglyceride levels ( 32154731 32203549) Type 1 diabetes ( 34127860) Vitiligo ( 27723757)
Interacting Genes		30 interacting genes: ABCA1 ABCC2 ABCC4 ACE2 AKAP10 APP CFTR CLCN3 CRHR1 FARP2 GFAP NHERF2 PDZK1IP1 PEX5 RPS6KA1 SCARB1 SLC13A1 SLC15A2 SLC17A1 SLC22A11 SLC22A12 SLC22A4 SLC22A5 SLC26A6 SLC34A1 SLC9A3 SLCO1A2 SLK SSTR5 UBE2I	9 interacting genes: BGLT3 CDH1 CDK4 CDK6 PDZK1 SRC UBC UBE2G2 YWHAG
Entrez ID		5174	9855
HPRD ID		04829	16885
Ensembl ID		ENSG00000174827	ENSG00000006607
Uniprot IDs		B2R7S7 Q5T2W1	O94887
PDB IDs		2EEI 2EEJ 2VSP 3TMH 4Q2P 6EZI
Enriched GO Terms of Interacting Partners?		Apical Plasma Membrane Transmembrane Transport PDZ Domain Binding Monoatomic Ion Transport Organic Anion Transport Transmembrane Transporter Activity Brush Border Membrane Plasma Membrane Inorganic Anion Transport Organic Hydroxy Compound Transport Carboxylic Acid Transport Organic Acid Transport Xenobiotic Transport Symporter Activity Inorganic Anion Transmembrane Transport Monoatomic Anion Transmembrane Transport Monoatomic Anion Transport Membrane Urate Transport Monoatomic Ion Transmembrane Transport Urate Metabolic Process ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Sodium Ion Transport ABC-type Transporter Activity Lipid Transport Cell Surface Xenobiotic Export From Cell Monocarboxylic Acid Transport Apolipoprotein Binding Export Across Plasma Membrane Organic Anion Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Basal Plasma Membrane Import Across Plasma Membrane Vascular Process In Circulatory System Bile Acid And Bile Salt Transport Xenobiotic Transmembrane Transporter Activity Amino-acid Betaine Transmembrane Transporter Activity Chemical Homeostasis Transport Across Blood-brain Barrier Regulation Of Intracellular PH Organic Cation Transport Regulation Of Cellular PH Circulatory System Process Inorganic Ion Transmembrane Transport Carnitine Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Antiporter Activity Peptide Transport Regulation Of PH	Regulation Of Cellular Localization Regulation Of Protein Localization Cyclin Binding Cyclin-dependent Protein Serine/threonine Kinase Activity Modification-dependent Protein Catabolic Process Regulation Of Cell Adhesion Regulation Of Intracellular Transport Negative Regulation Of Cell Adhesion Positive Regulation Of Fibroblast Proliferation Cyclin-dependent Protein Kinase Holoenzyme Complex Cyclin D2-CDK6 Complex Post-translational Protein Modification Negative Regulation Of TORC1 Signaling Proteolysis Involved In Protein Catabolic Process Positive Regulation Of TORC1 Signaling TORC1 Signaling Cellular Response To Oxygen-containing Compound Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of Fibroblast Proliferation Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Negative Regulation Of TOR Signaling TOR Signaling Positive Regulation Of TOR Signaling Positive Regulation Of Protein Localization To Nucleus Regulation Of TORC1 Signaling Positive Regulation Of Protein Localization Regulation Of G2/M Transition Of Mitotic Cell Cycle Macromolecule Catabolic Process Cyclin D2-CDK4 Complex Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Proteasomal Protein Catabolic Process Protein Kinase C Inhibitor Activity Regulation Of Establishment Of Protein Localization Extracellular Exosome Regulation Of Cell-cell Adhesion Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Regulation Of Cell Cycle G2/M Phase Transition Protein Kinase Activity Regulation Of Cell-matrix Adhesion Epithelial Cell Development Positive Regulation Of Cell Adhesion Negative Regulation Of Immune System Process Scavenger Receptor Binding Cellular Response To Progesterone Stimulus
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