PDZK1 and SLC22A5

Number of citations of the paper that reports this interaction (PMID 15523054)
9

Data Source:
HPRD (in vitro, two hybrid)

		PDZK1	SLC22A5
Gene Name		PDZ domain containing 1	solute carrier family 22 (organic cation/carnitine transporter), member 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Apical Plasma Membrane Brush Border Membrane Microvillus Membrane Membrane Raft Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Brush Border Membrane Extracellular Vesicular Exosome
	Molecular Function	Scavenger Receptor Binding Transporter Activity Protein Binding PDZ Domain Binding Protein Complex Binding	Protein Binding ATP Binding Carnitine Transmembrane Transporter Activity Drug Transmembrane Transporter Activity Symporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity PDZ Domain Binding Antibiotic Transporter Activity
	Biological Process	Transport Cell Proliferation Carnitine Transport Drug Transport Positive Regulation Of Ion Transmembrane Transport Regulation Of Anion Transport Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane	Sodium Ion Transport Drug Transmembrane Transport Quaternary Ammonium Group Transport Carnitine Transport Drug Transport Antibiotic Transport Quorum Sensing Involved In Interaction With Host Transmembrane Transport Positive Regulation Of Intestinal Epithelial Structure Maintenance Sodium-dependent Organic Cation Transport Carnitine Transmembrane Transport
Pathways			Organic cation transport Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds Organic cation/anion/zwitterion transport SLC-mediated transmembrane transport
Drugs			L-Carnitine
Diseases
GWAS		Urate levels ( 20884846 23263486) Uric acid levels ( 19503597)	Asthma ( 20860503) Crohn's disease ( 21102463) Fibrinogen ( 20031577) Height ( 20881960) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		27 interactors: ABCA1 ABCC2 ABCC4 AKAP10 APP CFTR CLCN3 FARP2 GFAP PDZK1IP1 PEX5 SCARB1 SLC15A2 SLC17A1 SLC22A11 SLC22A12 SLC22A4 SLC22A5 SLC26A6 SLC34A3 SLC9A3 SLC9A3R1 SLC9A3R2 SLCO1A2 SLK SSTR5 UBE2I	4 interactors: PDZD3 PDZK1 SLC9A3R1 SLC9A3R2
Entrez ID		5174	6584
HPRD ID		04829	04539
Ensembl ID		ENSG00000174827	ENSG00000197375
Uniprot IDs		Q5T2W1	O76082
PDB IDs		2EEI 2EEJ 2VSP 3TMH
Enriched GO Terms of Interacting Partners?		Anion Transport Transmembrane Transport Anion Transmembrane Transport Organic Anion Transport Ion Transport Ion Transmembrane Transport Homeostatic Process Chemical Homeostasis Ion Homeostasis Monocarboxylic Acid Transport Inorganic Anion Transport Transport Organic Acid Transport Anion Homeostasis Urate Metabolic Process Sodium Ion Transport Cellular Ion Homeostasis Cellular Homeostasis Lipid Transport Regulation Of PH Carboxylic Acid Transport Response To Drug Cellular Chemical Homeostasis Lipid Localization Monovalent Inorganic Cation Transport Antibiotic Transport Steroid Metabolic Process Cholesterol Metabolic Process Regulation Of Intracellular PH Regulation Of Cellular PH Sterol Metabolic Process Drug Transport Cellular Phosphate Ion Homeostasis Intracellular PH Elevation Cell Maturation Sodium-dependent Phosphate Transport Transepithelial Chloride Transport Neuron Remodeling Secretion Cholesterol Transport Sterol Transport Oligopeptide Transport Carnitine Transmembrane Transport Carnitine Transport Small Molecule Metabolic Process Transepithelial Transport Phosphate Ion Homeostasis Phosphate Ion Transmembrane Transport Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Peptide Transport	Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of CGMP Biosynthetic Process Renal Phosphate Ion Absorption Negative Regulation Of Guanylate Cyclase Activity Monocarboxylic Acid Transport Glutathione Transport Negative Regulation Of Sodium:proton Antiporter Activity Renal Sodium Ion Transport Cellular Phosphate Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Sodium:proton Antiporter Activity Carboxylic Acid Transport Organic Acid Transport Negative Regulation Of Sodium Ion Transmembrane Transport Phospholipase C-activating Dopamine Receptor Signaling Pathway Ion Transport Bile Acid Secretion CGMP-mediated Signaling Receptor Guanylyl Cyclase Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Regulation Of Ion Transmembrane Transport Oligopeptide Transport Carnitine Transport Organic Anion Transport Negative Regulation Of Sodium Ion Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Renal Absorption Regulation Of Proton Transport Phosphate Ion Homeostasis Microvillus Assembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Microvillus Organization Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Quaternary Ammonium Group Transport Regulation Of CGMP Biosynthetic Process Negative Regulation Of Lyase Activity Regulation Of Ion Transport Regulation Of Excretion Monovalent Inorganic Cation Transport Anion Transport Regulation Of Sodium Ion Transmembrane Transporter Activity Cyclic-nucleotide-mediated Signaling Bile Acid And Bile Salt Transport Regulation Of CGMP Metabolic Process Positive Regulation Of Protein Targeting To Membrane Dopamine Receptor Signaling Pathway Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Nucleotide Metabolic Process
Tagcloud ?		across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pgr premenopausal progesterone rankl responsiveness rhythm runx1 serpina3 serpina5 tff1 tumours varies w1 w2 w3 windows	abstracted alleles c113y cardiomyopathy carnitine compound confirm corresponding deficiency detect frequently genomic heterozygous homozygous missense mutated mutation mutations nonsense parents pcd polyphen predict r254x r289x sanger sequencing sift throughput
Tagcloud (Difference) ?		across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pgr premenopausal progesterone rankl responsiveness rhythm runx1 serpina3 serpina5 tff1 tumours varies w1 w2 w3 windows	abstracted alleles c113y cardiomyopathy carnitine compound confirm corresponding deficiency detect frequently genomic heterozygous homozygous missense mutated mutation mutations nonsense parents pcd polyphen predict r254x r289x sanger sequencing sift throughput
Tagcloud (Intersection) ?