PDZK1 and SSTR5

Number of citations of the paper that reports this interaction (PMID 16012170)
16

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		PDZK1	SSTR5
Gene Name		PDZ domain containing 1	somatostatin receptor 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Apical Plasma Membrane Brush Border Membrane Microvillus Membrane Membrane Raft Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection
	Molecular Function	Scavenger Receptor Binding Transporter Activity Protein Binding PDZ Domain Binding Protein Complex Binding	Somatostatin Receptor Activity Neuropeptide Binding
	Biological Process	Transport Cell Proliferation Carnitine Transport Drug Transport Positive Regulation Of Ion Transmembrane Transport Regulation Of Anion Transport Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane	G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Synaptic Transmission Negative Regulation Of Cell Proliferation Positive Regulation Of Cytokinesis Somatostatin Signaling Pathway Glucose Homeostasis Regulation Of Insulin Secretion Cellular Response To Glucocorticoid Stimulus Cellular Response To Estradiol Stimulus
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Urate levels ( 20884846 23263486) Uric acid levels ( 19503597)
Protein-Protein Interactions		27 interactors: ABCA1 ABCC2 ABCC4 AKAP10 APP CFTR CLCN3 FARP2 GFAP PDZK1IP1 PEX5 SCARB1 SLC15A2 SLC17A1 SLC22A11 SLC22A12 SLC22A4 SLC22A5 SLC26A6 SLC34A3 SLC9A3 SLC9A3R1 SLC9A3R2 SLCO1A2 SLK SSTR5 UBE2I	8 interactors: ADCY10 CORT DRD2 GOPC PDZK1 PEX5 SST SSTR1
Entrez ID		5174	6755
HPRD ID		04829	01677
Ensembl ID		ENSG00000174827	ENSG00000162009
Uniprot IDs		Q5T2W1	P35346
PDB IDs		2EEI 2EEJ 2VSP 3TMH
Enriched GO Terms of Interacting Partners?		Anion Transport Transmembrane Transport Anion Transmembrane Transport Organic Anion Transport Ion Transport Ion Transmembrane Transport Homeostatic Process Chemical Homeostasis Ion Homeostasis Monocarboxylic Acid Transport Inorganic Anion Transport Transport Organic Acid Transport Anion Homeostasis Urate Metabolic Process Sodium Ion Transport Cellular Ion Homeostasis Cellular Homeostasis Lipid Transport Regulation Of PH Carboxylic Acid Transport Response To Drug Cellular Chemical Homeostasis Lipid Localization Monovalent Inorganic Cation Transport Antibiotic Transport Steroid Metabolic Process Cholesterol Metabolic Process Regulation Of Intracellular PH Regulation Of Cellular PH Sterol Metabolic Process Drug Transport Cellular Phosphate Ion Homeostasis Intracellular PH Elevation Cell Maturation Sodium-dependent Phosphate Transport Transepithelial Chloride Transport Neuron Remodeling Secretion Cholesterol Transport Sterol Transport Oligopeptide Transport Carnitine Transmembrane Transport Carnitine Transport Small Molecule Metabolic Process Transepithelial Transport Phosphate Ion Homeostasis Phosphate Ion Transmembrane Transport Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Peptide Transport	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Synaptic Transmission Cerebral Cortex Neuron Differentiation Positive Regulation Of Multicellular Organism Growth Cell-cell Signaling Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Forebrain Development G-protein Coupled Receptor Signaling Pathway Cytoplasmic Sequestering Of CFTR Protein Regulation Of Multicellular Organism Growth Telencephalon Cell Migration Forebrain Cell Migration Spermatogenesis Male Gamete Generation Response To Drug Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Protein Homotetramerization Digestion Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Neuromuscular Process Monocarboxylic Acid Transport Regulation Of Protein Transport Hormone-mediated Signaling Pathway Regulation Of Anion Transport Regulation Of Locomotion Involved In Locomotory Behavior Protein Import Into Peroxisome Matrix, Translocation Negative Regulation Of Dopamine Receptor Signaling Pathway Gamete Generation Positive Regulation Of Developmental Growth Negative Regulation Of Cell Proliferation Regulation Of Establishment Of Protein Localization Cytoplasmic Transport Negative Regulation Of Dopamine Secretion Protein Import Into Peroxisome Matrix, Docking Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Branching Morphogenesis Of A Nerve Neuron Migration Negative Regulation Of Voltage-gated Calcium Channel Activity Orbitofrontal Cortex Development Somatostatin Signaling Pathway Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Protein Transport Brain Development Regulation Of Protein Localization Sexual Reproduction Head Development Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Protein Homooligomerization Hormone-mediated Apoptotic Signaling Pathway Regulation Of Dopamine Receptor Signaling Pathway
Tagcloud ?		across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pgr premenopausal progesterone rankl responsiveness rhythm runx1 serpina3 serpina5 tff1 tumours varies w1 w2 w3 windows	camk1 centriole dkk1 enah endosome geo gpsm2 inference kcnq3 kpna2 lcn2 lef1 lysosome map2k6 multivesicular nkx2 nr5a1 nup62 ontology phosphoinositide sfrp4 slc4a3 sort1 stx1a subnetwork tbl3 transport tshb ube2c
Tagcloud (Difference) ?		across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pgr premenopausal progesterone rankl responsiveness rhythm runx1 serpina3 serpina5 tff1 tumours varies w1 w2 w3 windows	camk1 centriole dkk1 enah endosome geo gpsm2 inference kcnq3 kpna2 lcn2 lef1 lysosome map2k6 multivesicular nkx2 nr5a1 nup62 ontology phosphoinositide sfrp4 slc4a3 sort1 stx1a subnetwork tbl3 transport tshb ube2c
Tagcloud (Intersection) ?