PDZK1 and ABCC4

Number of citations of the paper that reports this interaction (PMID 18045536)
52

Data Source:
BioGRID (pull down)

		PDZK1	ABCC4
Gene Name		PDZ domain containing 1	ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Apical Plasma Membrane Brush Border Membrane Microvillus Membrane Membrane Raft Extracellular Vesicular Exosome	Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Platelet Dense Granule Membrane
	Molecular Function	Scavenger Receptor Binding Transporter Activity Protein Binding PDZ Domain Binding Protein Complex Binding	ATP Binding 15-hydroxyprostaglandin Dehydrogenase (NAD+) Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances
	Biological Process	Transport Cell Proliferation Carnitine Transport Drug Transport Positive Regulation Of Ion Transmembrane Transport Regulation Of Anion Transport Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane	Platelet Degranulation Blood Coagulation Biological_process Response To Organonitrogen Compound Response To Organic Cyclic Compound Platelet Activation Response To Drug Positive Regulation Of Smooth Muscle Cell Proliferation Transmembrane Transport Oxidation-reduction Process
Pathways			ABC-family proteins mediated transport Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS		Urate levels ( 20884846 23263486) Uric acid levels ( 19503597)	Breast cancer ( 17903305) Longevity ( 20834067) Platelet counts ( 22139419) Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer ( 23478653)
Protein-Protein Interactions		27 interactors: ABCA1 ABCC2 ABCC4 AKAP10 APP CFTR CLCN3 FARP2 GFAP PDZK1IP1 PEX5 SCARB1 SLC15A2 SLC17A1 SLC22A11 SLC22A12 SLC22A4 SLC22A5 SLC26A6 SLC34A3 SLC9A3 SLC9A3R1 SLC9A3R2 SLCO1A2 SLK SSTR5 UBE2I	5 interactors: ERBB2IP PDZK1 SLC9A3R1 SLC9A3R2 SNTA1
Entrez ID		5174	10257
HPRD ID		04829	05583
Ensembl ID		ENSG00000174827	ENSG00000125257
Uniprot IDs		Q5T2W1	B7Z3Q7 O15439
PDB IDs		2EEI 2EEJ 2VSP 3TMH
Enriched GO Terms of Interacting Partners?		Anion Transport Transmembrane Transport Anion Transmembrane Transport Organic Anion Transport Ion Transport Ion Transmembrane Transport Homeostatic Process Chemical Homeostasis Ion Homeostasis Monocarboxylic Acid Transport Inorganic Anion Transport Transport Organic Acid Transport Anion Homeostasis Urate Metabolic Process Sodium Ion Transport Cellular Ion Homeostasis Cellular Homeostasis Lipid Transport Regulation Of PH Carboxylic Acid Transport Response To Drug Cellular Chemical Homeostasis Lipid Localization Monovalent Inorganic Cation Transport Antibiotic Transport Steroid Metabolic Process Cholesterol Metabolic Process Regulation Of Intracellular PH Regulation Of Cellular PH Sterol Metabolic Process Drug Transport Cellular Phosphate Ion Homeostasis Intracellular PH Elevation Cell Maturation Sodium-dependent Phosphate Transport Transepithelial Chloride Transport Neuron Remodeling Secretion Cholesterol Transport Sterol Transport Oligopeptide Transport Carnitine Transmembrane Transport Carnitine Transport Small Molecule Metabolic Process Transepithelial Transport Phosphate Ion Homeostasis Phosphate Ion Transmembrane Transport Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Peptide Transport	Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Sodium Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Regulation Of Sodium Ion Transport Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Ion Transport Regulation Of Vasoconstriction By Circulating Norepinephrine Renal Phosphate Ion Absorption Monocarboxylic Acid Transport Basal Protein Localization Glutathione Transport Negative Regulation Of Sodium:proton Antiporter Activity Renal Sodium Ion Transport Negative Regulation Of Peptidyl-cysteine S-nitrosylation Cellular Phosphate Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium Ion Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Cellular Protein Localization Phospholipase C-activating Dopamine Receptor Signaling Pathway Bile Acid Secretion Oligopeptide Transport Carnitine Transport Negative Regulation Of Sodium Ion Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Renal Absorption Regulation Of Proton Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Phosphate Ion Homeostasis Negative Regulation Of Intracellular Signal Transduction Microvillus Assembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Organic Anion Transport Microvillus Organization Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Quaternary Ammonium Group Transport Ventricular Cardiac Muscle Cell Action Potential Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization Regulation Of Membrane Repolarization Regulation Of Excretion Asymmetric Protein Localization Establishment Or Maintenance Of Apical/basal Cell Polarity Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Sodium Ion Transmembrane Transporter Activity Bile Acid And Bile Salt Transport Positive Regulation Of Protein Targeting To Membrane Monovalent Inorganic Cation Transport
Tagcloud ?		across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pgr premenopausal progesterone rankl responsiveness rhythm runx1 serpina3 serpina5 tff1 tumours varies w1 w2 w3 windows	abcb1 antagonize antioxidants caco cassette chemoresistance cnts concurrently devices dimethylthiourea extrusion forced hold integral mdr mecaptoethanol mrp4 multiwalled mwcnt mwcnts nanotubes overcome pgp promise proto shed transporter transporters
Tagcloud (Difference) ?		across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pgr premenopausal progesterone rankl responsiveness rhythm runx1 serpina3 serpina5 tff1 tumours varies w1 w2 w3 windows	abcb1 antagonize antioxidants caco cassette chemoresistance cnts concurrently devices dimethylthiourea extrusion forced hold integral mdr mecaptoethanol mrp4 multiwalled mwcnt mwcnts nanotubes overcome pgp promise proto shed transporter transporters
Tagcloud (Intersection) ?