PDZK1 and SCARB1

Number of citations of the paper that reports this interaction (PMID 14551195)
39

Data Source:
HPRD (in vivo)

		PDZK1	SCARB1
Gene Name		PDZ domain containing 1	scavenger receptor class B, member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Apical Plasma Membrane Brush Border Membrane Microvillus Membrane Membrane Raft Extracellular Vesicular Exosome	Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Caveola Cell Surface Endocytic Vesicle Membrane Microvillus Membrane Extracellular Vesicular Exosome
	Molecular Function	Scavenger Receptor Binding Transporter Activity Protein Binding PDZ Domain Binding Protein Complex Binding	Lipopolysaccharide Binding Phosphatidylserine Binding Lipopolysaccharide Receptor Activity Transporter Activity Protein Binding 1-phosphatidylinositol Binding High-density Lipoprotein Particle Binding Low-density Lipoprotein Particle Binding Apolipoprotein Binding Apolipoprotein A-I Binding Protein Homodimerization Activity High-density Lipoprotein Particle Receptor Activity
	Biological Process	Transport Cell Proliferation Carnitine Transport Drug Transport Positive Regulation Of Ion Transmembrane Transport Regulation Of Anion Transport Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane	Endothelial Cell Proliferation Androgen Biosynthetic Process Cholesterol Catabolic Process Receptor-mediated Endocytosis Cell Adhesion Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Storage Regulation Of Phosphatidylcholine Catabolic Process Phospholipid Transport Lipopolysaccharide Transport Viral Process Lipopolysaccharide-mediated Signaling Pathway Detection Of Lipopolysaccharide Cholesterol Efflux High-density Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Clearance High-density Lipoprotein Particle Clearance Wound Healing Lipoprotein Metabolic Process Cholesterol Homeostasis Blood Vessel Endothelial Cell Migration Recognition Of Apoptotic Cell Reverse Cholesterol Transport Small Molecule Metabolic Process Adhesion Of Symbiont To Host Regulation Of Phagocytosis Positive Regulation Of Nitric-oxide Synthase Activity Triglyceride Homeostasis Cholesterol Import
Pathways
Drugs			Phosphatidylserine
Diseases
GWAS		Urate levels ( 20884846 23263486) Uric acid levels ( 19503597)	HDL cholesterol ( 20686565) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302 20442857) Renal cell carcinoma ( 21131975) Vitamin E levels ( 21729881)
Protein-Protein Interactions		27 interactors: ABCA1 ABCC2 ABCC4 AKAP10 APP CFTR CLCN3 FARP2 GFAP PDZK1IP1 PEX5 SCARB1 SLC15A2 SLC17A1 SLC22A11 SLC22A12 SLC22A4 SLC22A5 SLC26A6 SLC34A3 SLC9A3 SLC9A3R1 SLC9A3R2 SLCO1A2 SLK SSTR5 UBE2I	7 interactors: APOA1 APOA2 APOE KRTAP10-9 KRTAP5-9 PDZK1 PEX5
Entrez ID		5174	949
HPRD ID		04829	03024
Ensembl ID		ENSG00000174827	ENSG00000073060
Uniprot IDs		Q5T2W1	B3KW46 B4DZ71 B4E3I1 B7ZKQ9 F8W8N0 Q8WTV0
PDB IDs		2EEI 2EEJ 2VSP 3TMH
Enriched GO Terms of Interacting Partners?		Anion Transport Transmembrane Transport Anion Transmembrane Transport Organic Anion Transport Ion Transport Ion Transmembrane Transport Homeostatic Process Chemical Homeostasis Ion Homeostasis Monocarboxylic Acid Transport Inorganic Anion Transport Transport Organic Acid Transport Anion Homeostasis Urate Metabolic Process Sodium Ion Transport Cellular Ion Homeostasis Cellular Homeostasis Lipid Transport Regulation Of PH Carboxylic Acid Transport Response To Drug Cellular Chemical Homeostasis Lipid Localization Monovalent Inorganic Cation Transport Antibiotic Transport Steroid Metabolic Process Cholesterol Metabolic Process Regulation Of Intracellular PH Regulation Of Cellular PH Sterol Metabolic Process Drug Transport Cellular Phosphate Ion Homeostasis Intracellular PH Elevation Cell Maturation Sodium-dependent Phosphate Transport Transepithelial Chloride Transport Neuron Remodeling Secretion Cholesterol Transport Sterol Transport Oligopeptide Transport Carnitine Transmembrane Transport Carnitine Transport Small Molecule Metabolic Process Transepithelial Transport Phosphate Ion Homeostasis Phosphate Ion Transmembrane Transport Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Peptide Transport	High-density Lipoprotein Particle Clearance Positive Regulation Of Cholesterol Esterification High-density Lipoprotein Particle Assembly Regulation Of Cholesterol Esterification Phospholipid Efflux High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Reverse Cholesterol Transport Plasma Lipoprotein Particle Remodeling Positive Regulation Of Steroid Metabolic Process Cholesterol Efflux Plasma Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Regulation Of Plasma Lipoprotein Particle Levels Cholesterol Transport Sterol Transport Cholesterol Homeostasis Sterol Homeostasis Phototransduction, Visible Light Retinoid Metabolic Process Regulation Of Intestinal Cholesterol Absorption Protein Oxidation Diterpenoid Metabolic Process Detection Of Visible Light Regulation Of Lipid Transport Phospholipid Transport Negative Regulation Of Cytokine Secretion Involved In Immune Response Phototransduction Regulation Of Steroid Metabolic Process Organic Anion Transport Detection Of Light Stimulus Peptidyl-methionine Modification Peripheral Nervous System Axon Regeneration Triglyceride-rich Lipoprotein Particle Remodeling Cholesterol Metabolic Process Lipid Homeostasis Low-density Lipoprotein Particle Remodeling Isoprenoid Metabolic Process Negative Regulation Of Cholesterol Transport Sterol Metabolic Process Cellular Lipid Catabolic Process Regulation Of Cytokine Secretion Involved In Immune Response Lipoprotein Metabolic Process Detection Of Abiotic Stimulus Negative Regulation Of Lipase Activity Anion Transport Negative Regulation Of Lipid Transport Phosphatidylcholine Biosynthetic Process Acylglycerol Catabolic Process
Tagcloud ?		across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pgr premenopausal progesterone rankl responsiveness rhythm runx1 serpina3 serpina5 tff1 tumours varies w1 w2 w3 windows	abca1 alfalfa aragonesa breed concentrate contrary dams finishing grazed grazing indoors lambs lengths lpl lt ppara pparg rasa sf slaughtering srebp1 subcutaneous supplemented thoracis tocopherol tocopheryl ve10d ve20d ve30d
Tagcloud (Difference) ?		across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pgr premenopausal progesterone rankl responsiveness rhythm runx1 serpina3 serpina5 tff1 tumours varies w1 w2 w3 windows	abca1 alfalfa aragonesa breed concentrate contrary dams finishing grazed grazing indoors lambs lengths lpl lt ppara pparg rasa sf slaughtering srebp1 subcutaneous supplemented thoracis tocopherol tocopheryl ve10d ve20d ve30d
Tagcloud (Intersection) ?