PDZK1 and SLC9A3

Number of citations of the paper that reports this interaction (PMID 14531806)
31

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vitro)

		PDZK1	SLC9A3
Gene Name		PDZ domain containing 1	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Apical Plasma Membrane Brush Border Membrane Microvillus Membrane Membrane Raft Extracellular Vesicular Exosome	Plasma Membrane Brush Border Cell Surface Integral Component Of Membrane Apical Plasma Membrane Brush Border Membrane Extracellular Vesicular Exosome
	Molecular Function	Scavenger Receptor Binding Transporter Activity Protein Binding PDZ Domain Binding Protein Complex Binding	Protein Binding Sodium:proton Antiporter Activity PDZ Domain Binding
	Biological Process	Transport Cell Proliferation Carnitine Transport Drug Transport Positive Regulation Of Ion Transmembrane Transport Regulation Of Anion Transport Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane	Ion Transport Regulation Of PH Sodium Ion Transmembrane Transport Transmembrane Transport Hydrogen Ion Transmembrane Transport
Pathways			Sodium/Proton exchangers Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport
Drugs
Diseases
GWAS		Urate levels ( 20884846 23263486) Uric acid levels ( 19503597)	Ulcerative colitis ( 23128233)
Protein-Protein Interactions		27 interactors: ABCA1 ABCC2 ABCC4 AKAP10 APP CFTR CLCN3 FARP2 GFAP PDZK1IP1 PEX5 SCARB1 SLC15A2 SLC17A1 SLC22A11 SLC22A12 SLC22A4 SLC22A5 SLC26A6 SLC34A3 SLC9A3 SLC9A3R1 SLC9A3R2 SLCO1A2 SLK SSTR5 UBE2I	8 interactors: CHP1 CHP2 LRP2 MAST2 PDZK1 SHANK2 SLC9A3R1 SLC9A3R2
Entrez ID		5174	6550
HPRD ID		04829	01660
Ensembl ID		ENSG00000174827	ENSG00000066230
Uniprot IDs		Q5T2W1	P48764
PDB IDs		2EEI 2EEJ 2VSP 3TMH
Enriched GO Terms of Interacting Partners?		Anion Transport Transmembrane Transport Anion Transmembrane Transport Organic Anion Transport Ion Transport Ion Transmembrane Transport Homeostatic Process Chemical Homeostasis Ion Homeostasis Monocarboxylic Acid Transport Inorganic Anion Transport Transport Organic Acid Transport Anion Homeostasis Urate Metabolic Process Sodium Ion Transport Cellular Ion Homeostasis Cellular Homeostasis Lipid Transport Regulation Of PH Carboxylic Acid Transport Response To Drug Cellular Chemical Homeostasis Lipid Localization Monovalent Inorganic Cation Transport Antibiotic Transport Steroid Metabolic Process Cholesterol Metabolic Process Regulation Of Intracellular PH Regulation Of Cellular PH Sterol Metabolic Process Drug Transport Cellular Phosphate Ion Homeostasis Intracellular PH Elevation Cell Maturation Sodium-dependent Phosphate Transport Transepithelial Chloride Transport Neuron Remodeling Secretion Cholesterol Transport Sterol Transport Oligopeptide Transport Carnitine Transmembrane Transport Carnitine Transport Small Molecule Metabolic Process Transepithelial Transport Phosphate Ion Homeostasis Phosphate Ion Transmembrane Transport Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Peptide Transport	Regulation Of Sodium:proton Antiporter Activity Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Proton Transport Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Intracellular Protein Transport Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Intracellular Transport Regulation Of Sodium Ion Transmembrane Transport Regulation Of Intracellular Protein Transport Regulation Of Calcium-mediated Signaling Positive Regulation Of Protein Transport Regulation Of Sodium Ion Transport Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Regulation Of Intracellular Transport Renal Phosphate Ion Absorption Negative Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Phosphatase Activity Negative Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Sodium:proton Antiporter Activity Glutathione Transport Regulation Of Dephosphorylation Monocarboxylic Acid Transport Regulation Of Protein Transport Regulation Of Ion Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Monovalent Inorganic Cation Transport Regulation Of Establishment Of Protein Localization Positive Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Protein Glycosylation Regulation Of Protein Import Into Nucleus Positive Regulation Of Transport Regulation Of Signaling Renal Sodium Ion Transport Regulation Of Intracellular Signal Transduction Regulation Of Protein Localization Regulation Of Protein Localization To Nucleus Cellular Phosphate Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Ion Transport Cellular Component Assembly Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Sodium Ion Transmembrane Transport Protein Localization
Tagcloud ?		across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pgr premenopausal progesterone rankl responsiveness rhythm runx1 serpina3 serpina5 tff1 tumours varies w1 w2 w3 windows	1p11 1q42 allows approximate assigned candidate centromere chr chromosomes comparative cytogenetic deduce encoding exchanger expand integrates linkage localizations localized loci map mapping na orient position rat regionally respect unlikely
Tagcloud (Difference) ?		across agr2 differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pgr premenopausal progesterone rankl responsiveness rhythm runx1 serpina3 serpina5 tff1 tumours varies w1 w2 w3 windows	1p11 1q42 allows approximate candidate centromere chr chromosomes comparative cytogenetic deduce encoding exchanger expand integrates linkage localizations localized loci map mapping na orient position rat regionally respect unlikely
Tagcloud (Intersection) ?		assigned