PDZK1 and SLK

Number of citations: 0 (PubMedID 14531806)
Data Source: BioGRID (two hybrid, pull down)

		PDZK1	SLK
Name		PDZ domain containing 1	STE20 like kinase
Structure
GO Annotations	Cellular Component	Plasma Membrane Brush Border Membrane Apical Plasma Membrane Brush Border Membrane Microvillus Membrane Extracellular Exosome	Cytoplasm Cytosol Cell Leading Edge Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Scavenger Receptor Binding Protein Binding PDZ Domain Binding Protein-membrane Adaptor Activity Protein-containing Complex Binding Transporter Activator Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of Monoatomic Anion Transport Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Carnitine Transmembrane Transport Positive Regulation Of Protein Localization To Membrane Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane	Apoptotic Process Regulation Of Cell Migration Cytoplasmic Microtubule Organization Intracellular Signal Transduction Regulation Of Apoptotic Process Protein Autophosphorylation Regulation Of Focal Adhesion Assembly
Pathways		None	RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
Drugs		None	K-00546 2-[4-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]iminocyclohexa-2,5-dien-1-yl]acetonitrile Fostamatinib
GWAS		Contrast sensitivity ( 24152035 ) Gout ( 32238385 33832965 ) Serum uric acid levels ( 30993211 ) Urate levels ( 20884846 23263486 31578528 31985003 ) Urate levels in overweight individuals ( 25811787 ) Uric acid levels ( 19503597 )	Diastolic blood pressure ( 29403010 ) Lung adenocarcinoma ( 28604730 ) Lung cancer ( 28604730 ) Mean corpuscular hemoglobin ( 29403010 ) Mean corpuscular volume ( 29403010 ) Neuroblastoma or malignant cutaneous melanoma ( 31605138 ) Pulse pressure ( 30487518 ) Systolic blood pressure ( 30487518 ) Uterine fibroids ( 21460842 31649266 )
Interacting Genes		30 interacting genes: ABCA1 ABCC2 ABCC4 ACE2 AKAP10 APP CFTR CLCN3 CRHR1 FARP2 GFAP NHERF2 PDZK1IP1 PEX5 RPS6KA1 SCARB1 SLC13A1 SLC15A2 SLC17A1 SLC22A11 SLC22A12 SLC22A4 SLC22A5 SLC26A6 SLC34A1 SLC9A3 SLCO1A2 SLK SSTR5 UBE2I	3 interacting genes: CASP3 CLSTN1 PDZK1
Entrez ID		5174	9748
HPRD ID		04829	11585
Ensembl ID		ENSG00000174827	ENSG00000065613
Uniprot IDs		B2R7S7 Q5T2W1	Q9H2G2
PDB IDs		2EEI 2EEJ 2VSP 3TMH 4Q2P 6EZI	2J51 2JFL 2JFM 2UV2 4USF 6HVD 8BEM
GO Terms Enriched among Interactors		Apical Plasma Membrane Transmembrane Transport PDZ Domain Binding Monoatomic Ion Transport Organic Anion Transport Transmembrane Transporter Activity Brush Border Membrane Plasma Membrane Inorganic Anion Transport Organic Hydroxy Compound Transport Carboxylic Acid Transport Organic Acid Transport Xenobiotic Transport Symporter Activity Inorganic Anion Transmembrane Transport Monoatomic Anion Transmembrane Transport Monoatomic Anion Transport Membrane Urate Transport Monoatomic Ion Transmembrane Transport Urate Metabolic Process ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Sodium Ion Transport ABC-type Transporter Activity Lipid Transport Cell Surface Xenobiotic Export From Cell Monocarboxylic Acid Transport Apolipoprotein Binding Export Across Plasma Membrane Organic Anion Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Basal Plasma Membrane Import Across Plasma Membrane Vascular Process In Circulatory System Bile Acid And Bile Salt Transport Xenobiotic Transmembrane Transporter Activity Amino-acid Betaine Transmembrane Transporter Activity Chemical Homeostasis Transport Across Blood-brain Barrier Regulation Of Intracellular PH Organic Cation Transport Regulation Of Cellular PH Circulatory System Process Inorganic Ion Transmembrane Transport Carnitine Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Antiporter Activity Peptide Transport Regulation Of PH	Response To Anesthetic Anterior Neural Tube Closure Postsynaptic Density Protein-containing Complex Binding Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Cellular Response To Staurosporine Death-inducing Signaling Complex Luteolysis Glial Cell Apoptotic Process Phospholipase A2 Activator Activity Protein Localization To Cell Periphery Scavenger Receptor Binding Carnitine Transmembrane Transport Carnitine Transport Protein Localization To Membrane X11-like Protein Binding Postsynaptic Endosome Positive Regulation Of Pyroptotic Inflammatory Response Response To Cobalt Ion Fibroblast Apoptotic Process Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Amino-acid Betaine Transport Transporter Activator Activity Establishment Of Protein Localization To Postsynaptic Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Neurotransmitter Receptor Transport To Plasma Membrane Regulation Of Synaptic Vesicle Cycle Interleukin-18-mediated Signaling Pathway Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Activated T Cell Proliferation Regulation Of Monoatomic Anion Transport Xenobiotic Export From Cell Quaternary Ammonium Group Transport Neurotransmitter Receptor Transport Localization Within Membrane Negative Regulation Of B Cell Proliferation Death Receptor Binding Glutamatergic Synapse Protein Poly-ADP-ribosylation Positive Regulation Of Amyloid-beta Formation Aspartic-type Endopeptidase Activity Axonal Fasciculation Neuron Projection Fasciculation Platelet Formation Neurotrophin Signaling Pathway Positive Regulation Of Amyloid Precursor Protein Catabolic Process Response To X-ray Execution Phase Of Apoptosis Microvillus Membrane