PDZK1 and CRHR1

Number of citations of the paper that reports this interaction (PubMedID 23576434)
52

Data Source:
BioGRID (pull down)

		PDZK1	CRHR1
Description		PDZ domain containing 1	corticotropin releasing hormone receptor 1
Image
GO Annotations	Cellular Component	Plasma Membrane Brush Border Membrane Apical Plasma Membrane Brush Border Membrane Microvillus Membrane Extracellular Exosome	Endosome Plasma Membrane Membrane Neuron Projection Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Signaling Receptor Binding Scavenger Receptor Binding Protein Binding PDZ Domain Binding Protein-membrane Adaptor Activity Protein-containing Complex Binding Transporter Activator Activity	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Corticotrophin-releasing Factor Receptor Activity Corticotropin-releasing Hormone Receptor Activity Corticotropin-releasing Hormone Binding
	Biological Process	Regulation Of Monoatomic Anion Transport Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Carnitine Transmembrane Transport Positive Regulation Of Protein Localization To Membrane Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane	Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Female Pregnancy Parturition Hormone-mediated Signaling Pathway Adrenal Gland Development Cellular Response To Hormone Stimulus Exploration Behavior Fear Response Behavioral Response To Ethanol Regulation Of Transport Corticotropin Secretion General Adaptation Syndrome, Behavioral Process Cellular Response To Corticotropin-releasing Hormone Stimulus Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Corticosterone Secretion
Pathways			Class B/2 (Secretin family receptors) G alpha (s) signalling events
Drugs			Corticorelin ovine triflutate
Diseases
GWAS		Contrast sensitivity ( 24152035) Gout ( 32238385 33832965) Serum uric acid levels ( 30993211) Urate levels ( 20884846 23263486 31578528 31985003) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 19503597)	A body shape index ( 34021172) Accelerometer-based physical activity measurement (average acceleration) ( 29899525) Alcohol consumption (drinks per week) ( 30679032) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alcohol use disorder (total score) ( 30336701) Alzheimer's disease in APOE e4- carriers ( 25778476) Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982) Brain morphology (MOSTest) ( 32665545) Cerebral white matter volume ( 31530798) Cortical surface area (global PC1) ( 32198502) Daytime nap ( 33568662) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) General factor of neuroticism ( 30867560) Granulocyte count ( 27863252) Head circumference (infant) ( 22504419) Headache ( 29397368) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hip circumference adjusted for BMI ( 34021172) Household income (MTAG) ( 31844048) Idiopathic pulmonary fibrosis ( 24429156) Intake of total sugars ( 31005972) Intracranial volume ( 22504418) Joint mobility (Beighton score) ( 27182965) Left-handedness ( 32989287) Left–right brain asymmetry ( 33723403) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Lymphocyte count ( 32888494) Male-pattern baldness ( 28196072) Maximum habitual alcohol consumption ( 31151762) Medication use (antithrombotic agents) ( 31015401) Monobrow ( 27182965) Mood instability ( 31168069) Multiple system atrophy ( 27629089) Myeloid white cell count ( 27863252) Neuroticism ( 29255261) Neutrophil count ( 27863252) Parkinson's disease ( 31660654 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Primary biliary cirrhosis ( 22961000) Reticulocyte count ( 32888494) Schizophrenia ( 33169155) Subcortical brain region volumes ( 25607358) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		30 interacting genes: ABCA1 ABCC2 ABCC4 ACE2 AKAP10 APP CFTR CLCN3 CRHR1 FARP2 GFAP NHERF2 PDZK1IP1 PEX5 RPS6KA1 SCARB1 SLC13A1 SLC15A2 SLC17A1 SLC22A11 SLC22A12 SLC22A4 SLC22A5 SLC26A6 SLC34A1 SLC9A3 SLCO1A2 SLK SSTR5 UBE2I	20 interacting genes: ARRB1 ARRB2 CALM1 CRH DLG1 DLG4 GNAI1 GNAO1 GNAQ GNAS GOPC MAGI1 MAGI2 MAGI3 MPDZ PDZK1 PTPN13 SRPK1 UCN UCN3
Entrez ID		5174	1394
HPRD ID		04829	08830
Ensembl ID		ENSG00000174827	ENSG00000120088
Uniprot IDs		B2R7S7 Q5T2W1	B3SXS2 B3TIK8 G3CIS4 K9J956 P34998
PDB IDs		2EEI 2EEJ 2VSP 3TMH 4Q2P 6EZI	2L27 3EHS 3EHT 3EHU 4K5Y 4Z9G 6P9X 6PB0 8GTG 8GTI 8GTM
Enriched GO Terms of Interacting Partners?		Apical Plasma Membrane Transmembrane Transport PDZ Domain Binding Monoatomic Ion Transport Organic Anion Transport Transmembrane Transporter Activity Brush Border Membrane Plasma Membrane Inorganic Anion Transport Organic Hydroxy Compound Transport Carboxylic Acid Transport Organic Acid Transport Xenobiotic Transport Symporter Activity Inorganic Anion Transmembrane Transport Monoatomic Anion Transmembrane Transport Monoatomic Anion Transport Membrane Urate Transport Monoatomic Ion Transmembrane Transport Urate Metabolic Process ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Sodium Ion Transport ABC-type Transporter Activity Lipid Transport Cell Surface Xenobiotic Export From Cell Monocarboxylic Acid Transport Apolipoprotein Binding Export Across Plasma Membrane Organic Anion Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Basal Plasma Membrane Import Across Plasma Membrane Vascular Process In Circulatory System Bile Acid And Bile Salt Transport Xenobiotic Transmembrane Transporter Activity Amino-acid Betaine Transmembrane Transporter Activity Chemical Homeostasis Transport Across Blood-brain Barrier Regulation Of Intracellular PH Organic Cation Transport Regulation Of Cellular PH Circulatory System Process Inorganic Ion Transmembrane Transport Carnitine Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Antiporter Activity Peptide Transport Regulation Of PH	Corticotropin-releasing Hormone Receptor 1 Binding Regulation Of System Process Regulation Of Transport Regulation Of Muscle System Process Guanyl Nucleotide Binding Corticotropin-releasing Hormone Receptor 2 Binding Adenylate Cyclase Regulator Activity G-protein Beta/gamma-subunit Complex Binding Plasma Membrane G Protein-coupled Receptor Binding D1 Dopamine Receptor Binding Heterotrimeric G-protein Complex Varicosity Regulation Of Peptide Hormone Secretion Bicellular Tight Junction Negative Regulation Of Transport Regulation Of Protein Localization Regulation Of Hormone Secretion Signal Transduction Angiotensin Receptor Binding Negative Regulation Of Hormone Secretion Mu-type Opioid Receptor Binding G Protein Activity Regulation Of Insulin Secretion Regulation Of Muscle Contraction Regulation Of Receptor Internalization G Protein-coupled Serotonin Receptor Signaling Pathway Positive Regulation Of Transport Beta-1 Adrenergic Receptor Binding G Protein-coupled Serotonin Receptor Binding Regulation Of Cell Communication Regulation Of Signaling Response To Prostaglandin E Positive Regulation Of Receptor Internalization Response To Ketone Regulation Of Multicellular Organismal Process Regulation Of Striated Muscle Contraction Ionotropic Glutamate Receptor Binding Cell Projection Regulation Of Monoatomic Ion Transport Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Localization Postsynaptic Density Response To Alcohol Regulation Of Receptor-mediated Endocytosis Adenylate Cyclase Activator Activity Regulation Of Protein Secretion Dendrite Desensitization Of G Protein-coupled Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?