PDZK1 and AKAP10

Number of citations of the paper that reports this interaction (PMID 14531806)
31

Data Source:
HPRD (two hybrid, in vitro)

		PDZK1	AKAP10
Gene Name		PDZ domain containing 1	A kinase (PRKA) anchor protein 10
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Apical Plasma Membrane Brush Border Membrane Microvillus Membrane Membrane Raft Extracellular Vesicular Exosome	Cytoplasm Mitochondrion Cytosol Plasma Membrane
	Molecular Function	Scavenger Receptor Binding Transporter Activity Protein Binding PDZ Domain Binding Protein Complex Binding
	Biological Process	Transport Cell Proliferation Carnitine Transport Drug Transport Positive Regulation Of Ion Transmembrane Transport Regulation Of Anion Transport Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane	Signal Transduction Blood Coagulation Protein Localization Termination Of G-protein Coupled Receptor Signaling Pathway
Pathways			Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Urate levels ( 20884846 23263486) Uric acid levels ( 19503597)	Platelet counts ( 22139419)
Protein-Protein Interactions		27 interactors: ABCA1 ABCC2 ABCC4 AKAP10 APP CFTR CLCN3 FARP2 GFAP PDZK1IP1 PEX5 SCARB1 SLC15A2 SLC17A1 SLC22A11 SLC22A12 SLC22A4 SLC22A5 SLC26A6 SLC34A3 SLC9A3 SLC9A3R1 SLC9A3R2 SLCO1A2 SLK SSTR5 UBE2I	5 interactors: PDZK1 PRKAR1A PRKAR2A PRKAR2B SLC9A3R1
Entrez ID		5174	11216
HPRD ID		04829	05259
Ensembl ID		ENSG00000174827	ENSG00000108599
Uniprot IDs		Q5T2W1	O43572
PDB IDs		2EEI 2EEJ 2VSP 3TMH	3IM4 3TMH
Enriched GO Terms of Interacting Partners?		Anion Transport Transmembrane Transport Anion Transmembrane Transport Organic Anion Transport Ion Transport Ion Transmembrane Transport Homeostatic Process Chemical Homeostasis Ion Homeostasis Monocarboxylic Acid Transport Inorganic Anion Transport Transport Organic Acid Transport Anion Homeostasis Urate Metabolic Process Sodium Ion Transport Cellular Ion Homeostasis Cellular Homeostasis Lipid Transport Regulation Of PH Carboxylic Acid Transport Response To Drug Cellular Chemical Homeostasis Lipid Localization Monovalent Inorganic Cation Transport Antibiotic Transport Steroid Metabolic Process Cholesterol Metabolic Process Regulation Of Intracellular PH Regulation Of Cellular PH Sterol Metabolic Process Drug Transport Cellular Phosphate Ion Homeostasis Intracellular PH Elevation Cell Maturation Sodium-dependent Phosphate Transport Transepithelial Chloride Transport Neuron Remodeling Secretion Cholesterol Transport Sterol Transport Oligopeptide Transport Carnitine Transmembrane Transport Carnitine Transport Small Molecule Metabolic Process Transepithelial Transport Phosphate Ion Homeostasis Phosphate Ion Transmembrane Transport Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Peptide Transport	Negative Regulation Of CAMP-dependent Protein Kinase Activity Regulation Of CAMP-dependent Protein Kinase Activity Renal System Process Activation Of Protein Kinase A Activity Renal Water Homeostasis Cellular Response To Glucagon Stimulus Water Transport Fluid Transport Activation Of Phospholipase C Activity Multicellular Organismal Water Homeostasis Response To Glucagon Positive Regulation Of Phospholipase C Activity Water Homeostasis Positive Regulation Of Phospholipase Activity Negative Regulation Of Phosphorylation Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Negative Regulation Of Protein Serine/threonine Kinase Activity Energy Reserve Metabolic Process Regulation Of Protein Transport Regulation Of Secretion Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Establishment Of Protein Localization ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Protein Kinase Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Insulin Secretion Regulation Of Kinase Activity Regulation Of Protein Localization Negative Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Peptide Hormone Secretion Neurotrophin Signaling Pathway Negative Regulation Of Kinase Activity Chemical Homeostasis Regulation Of Hormone Secretion Activation Of Protein Kinase Activity Regulation Of Cellular Localization Negative Regulation Of Transferase Activity Energy Derivation By Oxidation Of Organic Compounds Regulation Of Protein Phosphorylation Negative Regulation Of Protein Phosphorylation Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of Protein Secretion Regulation Of Phosphorylation Generation Of Precursor Metabolites And Energy Homeostatic Process
Tagcloud ?		across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pgr premenopausal progesterone rankl responsiveness rhythm runx1 serpina3 serpina5 tff1 tumours varies w1 w2 w3 windows
Tagcloud (Difference) ?		across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pgr premenopausal progesterone rankl responsiveness rhythm runx1 serpina3 serpina5 tff1 tumours varies w1 w2 w3 windows
Tagcloud (Intersection) ?