PDZK1 and CLCN3

Number of citations of the paper that reports this interaction (PubMedID 12471024)
0

Data Source:
HPRD (in vitro, in vivo)

		PDZK1	CLCN3
Description		PDZ domain containing 1	chloride voltage-gated channel 3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Brush Border Membrane Apical Plasma Membrane Brush Border Membrane Microvillus Membrane Extracellular Exosome	Golgi Membrane Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Synaptic Vesicle External Side Of Plasma Membrane Cell Surface Endosome Membrane Vesicle Membrane Membrane Secretory Granule Synaptic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Ruffle Membrane Specific Granule Cell Projection Axon Terminus Phagocytic Vesicle Recycling Endosome Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Signaling Receptor Binding Scavenger Receptor Binding Protein Binding PDZ Domain Binding Protein-membrane Adaptor Activity Protein-containing Complex Binding Transporter Activator Activity	Nucleotide Binding Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Chloride Transmembrane Transporter Activity Antiporter Activity PDZ Domain Binding Chloride:proton Antiporter Activity Volume-sensitive Chloride Channel Activity
	Biological Process	Regulation Of Monoatomic Anion Transport Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Carnitine Transmembrane Transport Positive Regulation Of Protein Localization To Membrane Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane	Monoatomic Ion Transport Chloride Transport Regulation Of PH Phagocytosis, Engulfment Adult Locomotory Behavior Synaptic Transmission, Glutamatergic Photoreceptor Cell Maintenance Negative Regulation Of Cell Volume Endosomal Lumen Acidification Synaptic Transmission, GABAergic Transmembrane Transport Neuron Cellular Homeostasis Synaptic Vesicle Lumen Acidification Chloride Transmembrane Transport Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Pathways			Stimuli-sensing channels
Drugs
Diseases
GWAS		Contrast sensitivity ( 24152035) Gout ( 32238385 33832965) Serum uric acid levels ( 30993211) Urate levels ( 20884846 23263486 31578528 31985003) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 19503597)	Autism spectrum disorder or schizophrenia ( 28540026) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Schizophrenia ( 25056061 28991256 29483656 30285260)
Interacting Genes		30 interacting genes: ABCA1 ABCC2 ABCC4 ACE2 AKAP10 APP CFTR CLCN3 CRHR1 FARP2 GFAP NHERF2 PDZK1IP1 PEX5 RPS6KA1 SCARB1 SLC13A1 SLC15A2 SLC17A1 SLC22A11 SLC22A12 SLC22A4 SLC22A5 SLC26A6 SLC34A1 SLC9A3 SLCO1A2 SLK SSTR5 UBE2I	6 interacting genes: CFTR DNAJC5 GOPC HSPB1 NHERF1 PDZK1
Entrez ID		5174	1182
HPRD ID		04829	02785
Ensembl ID		ENSG00000174827	ENSG00000109572
Uniprot IDs		B2R7S7 Q5T2W1	B3KXK0 E9PE15 P51790
PDB IDs		2EEI 2EEJ 2VSP 3TMH 4Q2P 6EZI
Enriched GO Terms of Interacting Partners?		Apical Plasma Membrane Transmembrane Transport PDZ Domain Binding Monoatomic Ion Transport Organic Anion Transport Transmembrane Transporter Activity Brush Border Membrane Plasma Membrane Inorganic Anion Transport Organic Hydroxy Compound Transport Carboxylic Acid Transport Organic Acid Transport Xenobiotic Transport Symporter Activity Inorganic Anion Transmembrane Transport Monoatomic Anion Transmembrane Transport Monoatomic Anion Transport Membrane Urate Transport Monoatomic Ion Transmembrane Transport Urate Metabolic Process ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Sodium Ion Transport ABC-type Transporter Activity Lipid Transport Cell Surface Xenobiotic Export From Cell Monocarboxylic Acid Transport Apolipoprotein Binding Export Across Plasma Membrane Organic Anion Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Basal Plasma Membrane Import Across Plasma Membrane Vascular Process In Circulatory System Bile Acid And Bile Salt Transport Xenobiotic Transmembrane Transporter Activity Amino-acid Betaine Transmembrane Transporter Activity Chemical Homeostasis Transport Across Blood-brain Barrier Regulation Of Intracellular PH Organic Cation Transport Regulation Of Cellular PH Circulatory System Process Inorganic Ion Transmembrane Transport Carnitine Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Antiporter Activity Peptide Transport Regulation Of PH	Regulation Of Monoatomic Anion Transport PDZ Domain Binding Chloride Channel Regulator Activity Regulation Of Monoatomic Ion Transport Golgi-associated Vesicle Membrane 14-3-3 Protein Binding Apical Plasma Membrane Regulation Of Transport Lysosomal Membrane Microvillus Membrane Protein-membrane Adaptor Activity Vesicle Docking Involved In Exocytosis Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Negative Regulation Of Protein Kinase C Signaling Metanephric Glomerular Mesangial Cell Development Renal Phosphate Ion Absorption Negative Regulation Of Anion Channel Activity
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