PDZK1 and SLC22A11

Number of citations of the paper that reports this interaction (PubMedID 16236806)
0

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		PDZK1	SLC22A11
Description		PDZ domain containing 1	solute carrier family 22 member 11
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GO Annotations	Cellular Component	Plasma Membrane Brush Border Membrane Apical Plasma Membrane Brush Border Membrane Microvillus Membrane Extracellular Exosome	Plasma Membrane External Side Of Plasma Membrane Basal Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Scavenger Receptor Binding Protein Binding PDZ Domain Binding Protein-membrane Adaptor Activity Protein-containing Complex Binding Transporter Activator Activity	Solute:inorganic Anion Antiporter Activity Protein Binding Organic Anion Transmembrane Transporter Activity Prostaglandin Transmembrane Transporter Activity Antiporter Activity Sodium-independent Organic Anion Transmembrane Transporter Activity Transmembrane Transporter Activity
	Biological Process	Regulation Of Monoatomic Anion Transport Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Carnitine Transmembrane Transport Positive Regulation Of Protein Localization To Membrane Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane	Monoatomic Ion Transport Inorganic Anion Transport Organic Anion Transport Prostaglandin Transport Urate Metabolic Process Transmembrane Transport
Pathways			Organic anion transport by SLC22 transporters
Drugs			Cefotaxime Probenecid Ceftriaxone Lesinurad
Diseases
GWAS		Contrast sensitivity ( 24152035) Gout ( 32238385 33832965) Serum uric acid levels ( 30993211) Urate levels ( 20884846 23263486 31578528 31985003) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 19503597)	Body mass index ( 32363570) Gout ( 33832965 32238385) Gout vs asymptomatic hyperuricemia ( 33832965) Obesity-related traits ( 23251661) Renal underexcretion gout ( 32238385) Serum uric acid levels ( 26902266 30993211) Systemic lupus erythematosus ( 28714469) Urate levels ( 20884846 31578528 23263486) Urate levels in lean individuals ( 25811787) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 19503597) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		30 interacting genes: ABCA1 ABCC2 ABCC4 ACE2 AKAP10 APP CFTR CLCN3 CRHR1 FARP2 GFAP NHERF2 PDZK1IP1 PEX5 RPS6KA1 SCARB1 SLC13A1 SLC15A2 SLC17A1 SLC22A11 SLC22A12 SLC22A4 SLC22A5 SLC26A6 SLC34A1 SLC9A3 SLCO1A2 SLK SSTR5 UBE2I	3 interacting genes: CAV3 NHERF1 PDZK1
Entrez ID		5174	55867
HPRD ID		04829	06161
Ensembl ID		ENSG00000174827	ENSG00000168065
Uniprot IDs		B2R7S7 Q5T2W1	Q9NSA0
PDB IDs		2EEI 2EEJ 2VSP 3TMH 4Q2P 6EZI	8WJH
Enriched GO Terms of Interacting Partners?		Apical Plasma Membrane Transmembrane Transport PDZ Domain Binding Monoatomic Ion Transport Organic Anion Transport Transmembrane Transporter Activity Brush Border Membrane Plasma Membrane Inorganic Anion Transport Organic Hydroxy Compound Transport Carboxylic Acid Transport Organic Acid Transport Xenobiotic Transport Symporter Activity Inorganic Anion Transmembrane Transport Monoatomic Anion Transmembrane Transport Monoatomic Anion Transport Membrane Urate Transport Monoatomic Ion Transmembrane Transport Urate Metabolic Process ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Sodium Ion Transport ABC-type Transporter Activity Lipid Transport Cell Surface Xenobiotic Export From Cell Monocarboxylic Acid Transport Apolipoprotein Binding Export Across Plasma Membrane Organic Anion Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Basal Plasma Membrane Import Across Plasma Membrane Vascular Process In Circulatory System Bile Acid And Bile Salt Transport Xenobiotic Transmembrane Transporter Activity Amino-acid Betaine Transmembrane Transporter Activity Chemical Homeostasis Transport Across Blood-brain Barrier Regulation Of Intracellular PH Organic Cation Transport Regulation Of Cellular PH Circulatory System Process Inorganic Ion Transmembrane Transport Carnitine Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Antiporter Activity Peptide Transport Regulation Of PH	Protein Localization To Cell Periphery Protein Localization To Plasma Membrane Regulation Of Monoatomic Ion Transport Nucleus Localization Protein Localization To Membrane Microvillus Membrane Protein-membrane Adaptor Activity Localization Within Membrane Brush Border Membrane Regulation Of Sodium Ion Transport Regulation Of Cell Size PDZ Domain Binding Negative Regulation Of Monoatomic Ion Transport Plasma Membrane Organization Regulation Of Nerve Growth Factor Receptor Activity Negative Regulation Of Sarcomere Organization Regulation Of Signal Transduction By Receptor Internalization Negative Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Renal Phosphate Ion Absorption Negative Regulation Of MAPK Cascade Molecular Adaptor Activity Vesicle Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Caveolin-mediated Endocytosis Connexin Binding Positive Regulation Of Caveolin-mediated Endocytosis Detection Of Muscle Stretch Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Localization Regulation Of Metal Ion Transport Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Cellular Component Size Intracellular Protein Localization Regulation Of Transport Regulation Of Membrane Depolarization During Action Potential T-tubule Organization Cellular Response To Ionomycin Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Scavenger Receptor Binding Carnitine Transmembrane Transport Carnitine Transport Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity
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