PDZK1 and SLC22A11

Number of citations of the paper that reports this interaction (PMID 16236806)
11

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		PDZK1	SLC22A11
Gene Name		PDZ domain containing 1	solute carrier family 22 (organic anion/urate transporter), member 11
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Apical Plasma Membrane Brush Border Membrane Microvillus Membrane Membrane Raft Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Apical Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Scavenger Receptor Binding Transporter Activity Protein Binding PDZ Domain Binding Protein Complex Binding	Inorganic Anion Exchanger Activity Protein Binding Organic Anion Transmembrane Transporter Activity Sodium-independent Organic Anion Transmembrane Transporter Activity
	Biological Process	Transport Cell Proliferation Carnitine Transport Drug Transport Positive Regulation Of Ion Transmembrane Transport Regulation Of Anion Transport Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane	Organic Anion Transport Urate Metabolic Process Transmembrane Transport
Pathways			Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds Organic anion transport Organic cation/anion/zwitterion transport SLC-mediated transmembrane transport
Drugs			Probenecid
Diseases
GWAS		Urate levels ( 20884846 23263486) Uric acid levels ( 19503597)	Obesity-related traits ( 23251661) Urate levels ( 20884846 23263486) Uric acid levels ( 19503597)
Protein-Protein Interactions		27 interactors: ABCA1 ABCC2 ABCC4 AKAP10 APP CFTR CLCN3 FARP2 GFAP PDZK1IP1 PEX5 SCARB1 SLC15A2 SLC17A1 SLC22A11 SLC22A12 SLC22A4 SLC22A5 SLC26A6 SLC34A3 SLC9A3 SLC9A3R1 SLC9A3R2 SLCO1A2 SLK SSTR5 UBE2I	3 interactors: CAV3 PDZK1 SLC9A3R1
Entrez ID		5174	55867
HPRD ID		04829	06161
Ensembl ID		ENSG00000174827	ENSG00000168065
Uniprot IDs		Q5T2W1	Q9NSA0
PDB IDs		2EEI 2EEJ 2VSP 3TMH
Enriched GO Terms of Interacting Partners?		Anion Transport Transmembrane Transport Anion Transmembrane Transport Organic Anion Transport Ion Transport Ion Transmembrane Transport Homeostatic Process Chemical Homeostasis Ion Homeostasis Monocarboxylic Acid Transport Inorganic Anion Transport Transport Organic Acid Transport Anion Homeostasis Urate Metabolic Process Sodium Ion Transport Cellular Ion Homeostasis Cellular Homeostasis Lipid Transport Regulation Of PH Carboxylic Acid Transport Response To Drug Cellular Chemical Homeostasis Lipid Localization Monovalent Inorganic Cation Transport Antibiotic Transport Steroid Metabolic Process Cholesterol Metabolic Process Regulation Of Intracellular PH Regulation Of Cellular PH Sterol Metabolic Process Drug Transport Cellular Phosphate Ion Homeostasis Intracellular PH Elevation Cell Maturation Sodium-dependent Phosphate Transport Transepithelial Chloride Transport Neuron Remodeling Secretion Cholesterol Transport Sterol Transport Oligopeptide Transport Carnitine Transmembrane Transport Carnitine Transport Small Molecule Metabolic Process Transepithelial Transport Phosphate Ion Homeostasis Phosphate Ion Transmembrane Transport Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Peptide Transport	Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Ion Transmembrane Transport Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Transporter Activity Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Regulation Of Ion Transport Regulation Of Sodium Ion Transport Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Ion Transport Regulation Of Protein Kinase B Signaling Monocarboxylic Acid Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Protein Localization To Plasma Membrane Regulation Of Signal Transduction By Receptor Internalization Negative Regulation Of Sarcomere Organization Renal Phosphate Ion Absorption Regulation Of Nerve Growth Factor Receptor Activity Negative Regulation Of MAPK Cascade Cellular Protein Localization Negative Regulation Of Sodium:proton Antiporter Activity Glutathione Transport Plasma Membrane Organization Establishment Of Protein Localization To Membrane Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development T-tubule Organization Positive Regulation Of Caveolin-mediated Endocytosis Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Carboxylic Acid Transport Organic Acid Transport Protein Localization Renal Sodium Ion Transport Regulation Of Membrane Depolarization During Action Potential Cellular Phosphate Ion Homeostasis Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Negative Regulation Of Cardiac Muscle Cell Differentiation Protein Localization To Membrane Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Transport Negative Regulation Of Phosphorylation Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Caveolin-mediated Endocytosis Caveola Assembly Negative Regulation Of Intracellular Signal Transduction Endomembrane System Organization Negative Regulation Of Protein Localization To Cell Surface
Tagcloud ?		across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pgr premenopausal progesterone rankl responsiveness rhythm runx1 serpina3 serpina5 tff1 tumours varies w1 w2 w3 windows	aetiology ancestry college direction equivocal european europeans gckr genotyped gout hlf inconsistency inhbc loci maaori maf meeting obvious opposing pacific pdzk1 polynesian prkag2 replicated rheumatology sizes slc16a9 urate zealand
Tagcloud (Difference) ?		across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pgr premenopausal progesterone rankl responsiveness rhythm runx1 serpina3 serpina5 tff1 tumours varies w1 w2 w3 windows	aetiology ancestry college direction equivocal european europeans gckr genotyped gout hlf inconsistency inhbc loci maaori maf meeting obvious opposing pacific polynesian prkag2 replicated rheumatology sizes slc16a9 urate zealand
Tagcloud (Intersection) ?		pdzk1